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Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Neuropathology of Neurodegenerative Diseases
Book and Online - A Practical Guide
Kovacs
Editore
Cambridge University Press
Anno
2015
Pagine
316
ISBN
9781107442429
106,00 €
Description
This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.
- Written in accessible language, avoiding the use of overlapping and complicated nomenclature
- Includes sampling and staining strategies and molecular methodological approaches, orientating the reader in the laboratory techniques used in the diagnosis of neurodegenerative diseases
- Describes molecular pathologic features of neurodegenerative disease, enabling classification on a microscopic level
Table of Contents
List of contributors
1. Introduction: classification of neurodegenerative diseases Gabor G. Kovacs
2. Clinical aspects of dementia Erin C. Golden and Keith A. Josephs
3. Clinical aspects of movement disorders Walter Pirker
4. Ethical, health and safety considerations James W. Ironside
5. Practical approach to diagnosis: sampling and basic stainings Gabor G. Kovacs
6. Molecular methods Isidro Ferrer
7. Alzheimer's disease Charles Duyckaerts
8. Tauopathies Gabor G. Kovacs
9. Synucleinopathies Irina Alafuzoff, Maria Pikkarainen and Laura Parkkinen
10. Human prion diseases James W. Ironside, Diane L. Ritchie, Alexander H. Peden and Mark W. Head
11. Neurodegenerative diseases linked to trinucleotide repeats Charles Duyckaerts, Natacha Joyon and Alexandra Durr
12. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration Tibor Hortobágyi and Nigel J. Cairns
13. Other NDG conditions I: hereditary cerebral amyoid angiopathies Ruben Vidal and Bernardino Ghetti
14. Other NDG conditions II: familial encephalopathy with neuroserpin inclusion bodies Ruben Vidal and Bernardino Ghetti
15. Other NDG conditions III: hereditary ferritinopathies Ruben Vidal and Bernardino Ghetti
16. Other NDG conditions IV: neurodegeneration with brain iron accumulation Isidro Ferrer
17. Concomitant pathologies I: cerebrovascular diseases Isidro Ferrer
18. Concomitant pathologies II: neurodegenerative conditions Gabor G. Kovacs, Isidro Ferrer and Irina Alafuzoff
Appendix A. Molecular classification of frontotemporal lobar degeneration (FTLD) with genetic correlations Gabor G. Kovacs and Nigel J. Cairns
Appendix B. Scheme for evaluation of frontotemporal lobar degeneration (FTLD) Gabor G. Kovacs and Nigel J. Cairns
Index.
