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Libreria medica internazionale
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Neuroendocrine Neoplasia Management
New Approaches for Diagnosis and Treatment
Beretta, Berruti, Bombardieri, Fazio, Goletti
Editore
Springer
Anno
2021
Pagine
331
ISBN
9783030728298
140,00 €

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his book provides the most recent update on the management of neuroendocrine neoplasia (NEN), a term covering all tumors of various organs and/or with a particular histology, including MEN (multiple endocrine neoplasia) related tumors, MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasms), NEC (neuroendocrine carcinoma) and Merkel’s carcinoma. NENs are heterogeneous in their biology, clinical presentation and prognosis, showing a great variability in aggressiveness and therapy response. As a result, their treatment is based on a large spectrum of options. The standard therapies are surgery in early disease, various loco-regional procedures in certain conditions and mostly of a palliative nature in metastatic disease. At present, thanks to our increased understanding of molecular signaling pathways, several pharmacological approaches can be used in patients with advanced NENs. Somatostatin analogs display both anti-tumor effects and symptom control. Novel peptide-radio-receptor treatment (PRRT) is used in patients with well differentiated tumors. The agents targeting angiogenesis and/or PI3K/AKT/mTOR pathway, alone or in combination with analogues, have provided encouraging results in advanced disease.

The first part of the book focuses on the history, epidemiology and the most relevant scientific achievements, covering the discoveries in genetic and molecular biology, the endoscopic techniques with guided biopsy, and the metabolic imaging with hybrid PET/CT and MRI/CT. It particularly highlights the emerging strategies in therapy, surgery and mini-invasive surgery as well as loco-regional and systemic treatments, including targeted therapy and/or biological therapies. The second part then explores the management of NENs of various anatomical origins and/or with peculiar biology. It describes the range of the current options and the most relevant results from the clinical trials.

This informative book provides valuable insights for all those interested in the management of neuroendocrine neoplasia.

 

  • History of Neuroendocrine Neoplasia

    Pages 3-9

    Bajetta, Emilio (et al.)

  • Epidemiology of Neuroendocrine Neoplasms

    Pages 11-17

    Trama, Annalisa

  • New Concepts in Pathology

    Pages 21-36

    Milione, Massimo (et al.)

  • Molecular Biology of Neuroendocrine Tumors

    Pages 37-53

    Mafficini, Andrea (et al.)

  • Circulating Biochemical Markers of Gastro-Entero-Pancreatic (GEP) Neuroendocrine Neoplasms (NENs)

    Pages 55-74

    Cavalcoli, Federica (et al.)

    Advances in Diagnostic Imaging

  • Pages 75-98

    Pepe, Giovanna (et al.)

  • Treatment of NET-Related Symptoms

    Pages 101-111

    Grimaldi, Franco (et al.)

  • New Surgical Strategies

    Pages 113-128

    Andreasi, Valentina (et al.)

  • New Approaches in Medical Therapies

    Pages 129-136

    Rubino, Manila (et al.)

  • Locoregional Therapies of NEN

    Pages 137-148

    Orsi, Franco (et al.)

  • Radioreceptor Therapy

    Pages 149-159

    Lorenzoni, Alice (et al.)

  • NETs of the Lung

    Pages 163-178

    Prinzi, Natalie (et al.)

  • Gastric Neuroendocrine Tumors

    Pages 179-190

    Ravizza, Davide (et al.)

  • Treatment of Pancreatic Neuroendocrine Tumors

    Pages 191-199

    Carnaghi, Carlo (et al.)

  • Treatment of Intestinal NETs (Including Appendix)

    Pages 201-210

    Panzuto, Francesco (et al.)

  • Treatment of NETs from Rare Origin

    Pages 211-229

    Betella, Nazarena (et al.)

  • Neuroendocrine Neoplasms with Peculiar Biology and Features: MEN1, MEN2A, MEN2B, MEN4, VHL, NF1

    Pages 233-267

    Faggiano, Antongiulio (et al.)

  • Mixed Neuroendocrine and Non-neuroendocrine Neoplasms (Mi NEN)

    Pages 269-282

    Laffi, Alice (et al.)

  • Merkel Cell Carcinoma

    Pages 283-307

    Consoli, Francesca (et al.)

  • Therapy in Poorly Differentiated Neuroendocrine Neoplasms (NEN G3)

    Pages 309-323

    Squadroni, Michela (et al.)

  • Conclusions: NEN Management Today and Looking at the Future

    Pages 327-331

    Beretta, Giordano (et al.)

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