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his book provides the most recent update on the management of neuroendocrine neoplasia (NEN), a term covering all tumors of various organs and/or with a particular histology, including MEN (multiple endocrine neoplasia) related tumors, MiNEN (mixed neuroendocrine-non-neuroendocrine neoplasms), NEC (neuroendocrine carcinoma) and Merkel’s carcinoma. NENs are heterogeneous in their biology, clinical presentation and prognosis, showing a great variability in aggressiveness and therapy response. As a result, their treatment is based on a large spectrum of options. The standard therapies are surgery in early disease, various loco-regional procedures in certain conditions and mostly of a palliative nature in metastatic disease. At present, thanks to our increased understanding of molecular signaling pathways, several pharmacological approaches can be used in patients with advanced NENs. Somatostatin analogs display both anti-tumor effects and symptom control. Novel peptide-radio-receptor treatment (PRRT) is used in patients with well differentiated tumors. The agents targeting angiogenesis and/or PI3K/AKT/mTOR pathway, alone or in combination with analogues, have provided encouraging results in advanced disease.
The first part of the book focuses on the history, epidemiology and the most relevant scientific achievements, covering the discoveries in genetic and molecular biology, the endoscopic techniques with guided biopsy, and the metabolic imaging with hybrid PET/CT and MRI/CT. It particularly highlights the emerging strategies in therapy, surgery and mini-invasive surgery as well as loco-regional and systemic treatments, including targeted therapy and/or biological therapies. The second part then explores the management of NENs of various anatomical origins and/or with peculiar biology. It describes the range of the current options and the most relevant results from the clinical trials.
This informative book provides valuable insights for all those interested in the management of neuroendocrine neoplasia.
History of Neuroendocrine Neoplasia
Pages 3-9
Bajetta, Emilio (et al.)
Epidemiology of Neuroendocrine Neoplasms
Pages 11-17
Trama, Annalisa
New Concepts in Pathology
Pages 21-36
Milione, Massimo (et al.)
Molecular Biology of Neuroendocrine Tumors
Pages 37-53
Mafficini, Andrea (et al.)
Circulating Biochemical Markers of Gastro-Entero-Pancreatic (GEP) Neuroendocrine Neoplasms (NENs)
Pages 55-74
Cavalcoli, Federica (et al.)
Advances in Diagnostic Imaging
Pages 75-98
Pepe, Giovanna (et al.)
Treatment of NET-Related Symptoms
Pages 101-111
Grimaldi, Franco (et al.)
New Surgical Strategies
Pages 113-128
Andreasi, Valentina (et al.)
New Approaches in Medical Therapies
Pages 129-136
Rubino, Manila (et al.)
Locoregional Therapies of NEN
Pages 137-148
Orsi, Franco (et al.)
Radioreceptor Therapy
Pages 149-159
Lorenzoni, Alice (et al.)
NETs of the Lung
Pages 163-178
Prinzi, Natalie (et al.)
Gastric Neuroendocrine Tumors
Pages 179-190
Ravizza, Davide (et al.)
Treatment of Pancreatic Neuroendocrine Tumors
Pages 191-199
Carnaghi, Carlo (et al.)
Treatment of Intestinal NETs (Including Appendix)
Pages 201-210
Panzuto, Francesco (et al.)
Treatment of NETs from Rare Origin
Pages 211-229
Betella, Nazarena (et al.)
Neuroendocrine Neoplasms with Peculiar Biology and Features: MEN1, MEN2A, MEN2B, MEN4, VHL, NF1
Pages 233-267
Faggiano, Antongiulio (et al.)
Mixed Neuroendocrine and Non-neuroendocrine Neoplasms (Mi NEN)
Pages 269-282
Laffi, Alice (et al.)
Merkel Cell Carcinoma
Pages 283-307
Consoli, Francesca (et al.)
Therapy in Poorly Differentiated Neuroendocrine Neoplasms (NEN G3)
Pages 309-323
Squadroni, Michela (et al.)
Conclusions: NEN Management Today and Looking at the Future
Pages 327-331
Beretta, Giordano (et al.)
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