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This book is an up-to-date, comprehensive, clinically oriented guide to the diagnosis and treatment of patients with myocarditis. The opening chapters address the classification, histopathology and molecular diagnosis, as well as the polymorphic clinical presentations, ranging from myocardial infarction with normal coronary arteries; arrhythmias of variable type and clinical severity and fulminant, acute, sub-acute or chronic heart failure; to life-threatening unexplained cardiogenic shock and sudden cardiac death.
Including chapters from leading International experts in the field, it covers all key issues from bench to bedside. Topics presented include epidemiology, etiology, pathogenesis, clinical and diagnostic work-up, the role of endomyocardial biopsy and of non-invasive cardiac imaging, risk stratification, and cardiological and etiology-specific management and follow-up. For each topic, a comprehensive review of the current literature is provided and practical suggestions are offered for short- and long-term management. Lastly, future perspectives and gaps in the current knowledge are also addressed.
The book also covers a key discovery of last the 2 decades, namely the autoimmune origin of myocarditis in a sizable proportion of patients, discussing in detail the role of immunosuppression and immunomodulation, as well as the need for a multidisciplinary approach to the disease.
Mainly intended for cardiologists, general physicians, clinical immunologists and rheumatologists, it is also a valuable tool for residents in Cardiology, Internal Medicine, Clinical Immunology and Rheumatology.
Classification, Histopathology, Immunohistology, and Molecular Diagnosis of Myocarditis
Pages 1-17
Rizzo, Stefania (et al.)
Clinical Presentation of Myocarditis
Pages 19-36
Caforio, Alida L. P. (et al.)
Endomyocardial Biopsy
Pages 37-44
Chimenti, Cristina (et al.)
Genetic Basis of Myocarditis: Myth or Reality?
Pages 45-89
Arbustini, Eloisa (et al.)
Viral Myocarditis: From Experimental Models to Diagnosis in Patients
Pages 91-109
Pankuweit, Sabine (et al.)
Autoimmune Myocarditis: Animal Models
Pages 111-127
Poli, Valeria (et al.)
Electrocardiography
Pages 129-142
Rapezzi, Claudio (et al.)
Standard and Advanced Echocardiography
Pages 143-161
Gianstefani, Silvia (et al.)
Cardiac Magnetic Resonance Imaging in Myocarditis
Pages 163-171
Marra, Martina Perazzolo (et al.)
Organ-Specific Autoimmune Myocarditis
Pages 173-194
Caforio, Alida L. P. (et al.)
Myocarditis in Systemic Immune-Mediated Diseases
Pages 195-221
Caforio, Alida L. P. (et al.)
Giant Cell and Hypersensitivity Myocarditis
Pages 223-241
Gonzalez, Yahaira Ortiz (et al.)
Myocarditis in Children
Pages 243-260
Limongelli, Giuseppe (et al.)
Immunosuppressive Therapy in Myocarditis: Lessons from Clinical Trials and Future Perspectives
Pages 261-267
Frustaci, Andrea (et al.)
Immunomodulation and Immunoadsorption in Inflammatory Dilated Cardiomyopathy
Pages 269-283
Chamling, Bishwas (et al.)
Clinical Management and Follow-Up of Myocarditis Patients on Immunosuppressive Therapy
Pages 285-295
Marcolongo, Renzo (et al.)
Antiviral Therapies: A Critical Reappraisal
Pages 297-316
Elsanhoury, Ahmed (et al.)
Conventional Cardiological Therapies
Pages 317-328
Sinagra, Gianfranco (et al.)
Arrhythmias in Myocarditis
Pages 329-341
Vio, Riccardo (et al.)
Mechanical Assist Devices and Heart Transplantation
Pages 343-353
Gerosa, Gino (et al.)
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