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This book brings together the latest knowledge on moyamoya disease, covering diagnostic criteria, status as a disease entity, genetic aspects, pathophysiology, novel neuroradiological findings, and surgical therapy. Information is also provided on recent basic and clinical research with the aim of identifying future perspectives on the disease.
Since moyamoya disease was first reported in an English language article more than 50 years ago, our understanding of it has advanced considerably. Genetic and radiological analysis has delivered novel insights, and the latest multicenter studies are changing routine diagnosis and surgical therapy. The gene encoding the ring finger protein 213 (RNF213) has been identified as a susceptibility gene for moyamoya disease. Indications and procedures for surgical revascularization have been revised, with resultant improvements in outcomes, and studies performed over the past decade have provided new knowledge on the neuroradiological findings before and after surgery.
In describing these advances, this book will be an invaluable asset for all general physicians, pediatricians, neurologists, radiologists, and neurosurgeons who care for patients with moyamoya disease across the world.
History of Disease Entity and Diagnosis Criteria
Pages 3-15
Kuroda, Satoshi
Moyamoya Syndrome
Pages 17-32
Lucia, Kristin (et al.)
Unilateral Moyamoya Disease: A Distinct Entity?
Pages 33-44
Mineharu, Yohei (et al.)
RNF213 as a Susceptibility Gene for Moyamoya Disease has Multifunctional Roles in Biological Processes
Pages 47-60
Kobayashi, Hatasu (et al.)
RNF213
Pages 61-72
Nomura, Shunsuke (et al.)
RNF213
Pages 73-83
Miyawaki, Satoru (et al.)
TIA and Headache in Pediatric Moyamoya Disease
Pages 87-97
Kuroda, Satoshi
Ischemic Stroke
Pages 99-109
Uchino, Haruto (et al.)
Hemorrhagic Stroke and the Japan Adult Moyamoya Trial
Pages 111-123
Funaki, Takeshi (et al.)
Cognitive Function in Pediatric Moyamoya Disease
Pages 125-133
Kuroda, Satoshi
Cognitive Dysfunction in Adults
Pages 135-141
Takagi, Yasushi
Asymptomatic Moyamoya Disease
Pages 143-152
Kuroda, Satoshi
Periventricular Anastomosis
Pages 155-166
Funaki, Takeshi (et al.)
Arterial Shrinkage
Pages 167-180
Kuroda, Satoshi
Disease Progression
Pages 181-187
Fujimura, Miki (et al.)
Postoperative Hyperperfusion
Pages 189-201
Uchino, Haruto (et al.)
Postoperative FLAIR Imaging Changes
Pages 203-211
Kashiwazaki, Daina (et al.)
Overview of Surgical Revascularization and Long-Term Outcome in Japan
Pages 215-227
Kuroda, Satoshi
Perioperative Complications
Pages 229-240
Kazumata, Ken (et al.)
Long-Term Outcome in Europe
Pages 241-251
Mrosk, Friedrich (et al.)
Long-Term Outcomes in the USA
Pages 253-265
Ahmed, Syed Uzair (et al.)
Long-Term Outcome in China
Pages 267-281
Wei, Ni (et al.)
Long-Term Outcome of Revascularization Surgery for Moyamoya Disease in Korea
Pages 283-299
Kim, Jeong Eun (et al.)
Indirect Bypass Surgery for Moyamoya Disease
Pages 301-310
Nariai, Tadashi
Direct/Combined Bypass Surgery
Pages 311-323
Takahashi, Jun C.
Special Considerations: Infants
Pages 325-333
Kuroda, Satoshi (et al.)
Special Considerations: Elderly
Pages 335-341
Fujimura, Miki (et al.)
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