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Molecular Pathology of Neoplastic Gastrointestinal Diseases
Sepulveda, Lynch
Editore
Springer
Anno
2013
Pagine
277
ISBN
9781461460145
160,00 €
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.
  • Reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the GI tract providing the reader with current up to date knowledge
  • Emphasis on practical applications
  • Visual approach includes an abundance of tables and diagrams

Molecular Pathology of Neoplastic Gastrointestinal Diseases  reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on:

  • the molecular basis of the individual disease
  • molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies
  • recommended guidelines for clinical application of molecular tests are included whenever available
  • molecular testing for hereditary predisposition or disease risk
  • animal models and cell culture models of disease

Part I Introduction
1 Mechanisms of Gastrointestinal Carcinogenesis ................................................... 3
Frank I. Scott and John P. Lynch
Part II Epithelial Neoplastic Disease
2 Targeted Therapies and Molecular Diagnostics
of Gastrointestinal Cancers ..................................................................................... 33
Davendra Sohal, Antonia R. Sepulveda, and Weijing Sun
3 Molecular Pathology of Barrett’s Metaplasia
and Esophageal Adenocarcinoma .......................................................................... 43
Mamoun Younes
4 Molecular Pathology of Squamous Carcinomas of the Esophagus ..................... 53
Rohinton S. Tarapore and Jonathan P. Katz
5 Molecular Mechanisms and Pathology of Gastric Carcinogenesis:
Sporadic Cancers ..................................................................................................... 67
Shuko Harada and Antonia R. Sepulveda
6 Hereditary Diffuse Gastric Cancer and Other Gastric Cancers
Associated with Hereditary Predisposition Syndromes........................................ 83
Fátima Carneiro, Carla Oliveira, and Raquel Seruca
7 Cancer Predisposition Syndromes of the Gastrointestinal Tract ........................ 109
Ian S. Hagemann and Antonia R. Sepulveda
8 Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type......... 131
Asif Rashid
9 Cancers of the Rectum and Anal Canal ................................................................. 141
Jenia Jenab-Wolcott and Bruce Giantonio
10 Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia ....... 173
Takeshi Uehara, Deqin Ma, and Antonia R. Sepulveda
Part III Non-epithelial Neoplastic Tumors
11 Molecular Biology and Pathology of Gastrointestinal Stromal Tumors ............. 181
Paul J. Zhang
12 Neuroendocrine Tumors .......................................................................................... 193
Joseph R. Pisegna
Part IV Metastatic Disease and Tumor Markers
13 Molecular Mechanisms of Tumor Metastasis ........................................................ 213
Andrew D. Rhim, Davendra Sohal, and Hiroshi Nakagawa
14 Circulating Tumor Cells and Nucleic Acids for Tumor Diagnosis ...................... 229
Loren Joseph
15 Serological Markers of Digestive Tract Cancers ................................................... 249
Jorge L. Sepulveda
Index .................................................................................................................................. 271

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