Molecular Diagnostics in Cancer Patients

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Oncologia e Radioterapia

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Molecular Diagnostics in Cancer Patients

Editore

Springer

Anno

2019

Pagine

341

ISBN

9789811358760

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This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis.

The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques.

Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Recent Advances in Molecular Diagnostic Approaches for Cancer

Shukla, Kamla Kant (et al.)

Pages 1-9
Molecular Diagnosis of Gall Bladder Cancer

Rai, Rajani (et al.)

Pages 11-25
Molecular Diagnostics for Lung Cancer

Kumar, Ashok (et al.)

Pages 27-41
Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors

Joshi, Vibhuti (et al.)

Pages 43-72
Molecular Diagnostics in Melanoma: An Update

Srivastava, A. (et al.)

Pages 73-88

Molecular Diagnostics in Breast Cancer

Sinha, Rajeshwari (et al.)

Pages 89-102
Molecular Diagnostics in Non-Hodgkin Lymphoma

Pratap, Suraj (et al.)

Pages 103-127
Molecular Diagnosis of Cervical Cancer

Mittal, Balraj (et al.)

Pages 129-142
Molecular Diagnostics in Colorectal Cancer

Agrawal, Sandeep (et al.)

Pages 143-155
Molecular Diagnostics in Pancreatic Cancer

Mishra, Shruti (et al.)

Pages 157-163
Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma

Husain, Nuzhat (et al.)

Pages 165-185
Molecular Diagnostic in Prostate Cancer

Ahmad, Mohammad Kaleem (et al.)

Pages 187-198
Molecular Diagnostics in Renal Cancer

Sanganeria, Barkha Singhal (et al.)

Pages 199-218
Molecular Biomarkers and Urinary Bladder Cancer (UBC)

Srivastava, A. N. (et al.)

Pages 219-235
Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast

Jodlowski, Tomasz (et al.)

Pages 237-268
Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research

Singh, Neera (et al.)

Pages 269-292
Molecular Diagnostics in Liver Cancer

Chauhan, Anil Kumar (et al.)

Pages 293-303
Molecular Diagnosis of Uterine Cancer

Rai, Rajani (et al.)

Pages 305-321
Molecular Diagnosis in Ovarian Carcinoma

Dwivedi, Shailendra (et al.)

Pages 323-341