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Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits
Pages 3-19
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Molecular Allergy Diagnostics
Innovation for a Better Patient Management
Kleine-Tebbe,Jakob,
Editore
Springer
Anno
2017
Pagine
531
ISBN
9783319424989
170,00 €
DA SCONTARE
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis.
Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy.
The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
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Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-Associated Cross-Reactions
Pages 21-42
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The Concept of Pollen Panallergens: Profilins and Polcalcins
Pages 43-56
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Stable Plant Food Allergens I: Lipid-Transfer Proteins
Pages 57-75
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Stable Plant Food Allergens II: Storage Proteins
Pages 77-90
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Cross-Reactive Carbohydrate Determinants: Diagnostic and Clinical Relevance
Pages 91-108
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Molecular Allergy Diagnostics Using IgE Singleplex Assays: Methodological and Practical Considerations
Pages 111-156
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Spiking with Recombinant Individual Allergens for Improvement of Allergen Extracts
Pages 157-167
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Molecular Allergy Diagnostics Using Multiplex Assays
Pages 169-200
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Marker Allergens and Panallergens in Tree and Grass Pollen Allergy
Pages 203-226
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Marker Allergens of Weed Pollen: Basic Considerations and Diagnostic Benefits in Routine Clinical Practice
Pages 227-240
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Molecular Diagnostics for Peanut Allergy
Pages 241-256
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Molecular Diagnostics for Tree Nut Allergy
Pages 257-269
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Molecular Diagnostics of Allergy to Fruits and Vegetables
Pages 271-289
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Cow’s Milk and Hen’s Egg Allergy: What Do Molecular-Based Allergy Diagnostics Have to Offer?
Pages 291-303
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Molecular and Extract-Based Diagnostics in Meat Allergy
Pages 305-326
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Molecular Diagnostics in Food-Dependent Exercise-Induced Anaphylaxis
Pages 327-340
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Benefits and Limitations of Recombinant Allergens in Diagnostics of Insect Venom Allergy
Pages 341-362
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Molecular Diagnostics in Allergy to Mammals
Pages 363-379
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Extract-Based and Molecular Diagnostics in Fish Allergy
Pages 381-397
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Allergens and Molecular Diagnostics of Shellfish Allergy
Pages 399-414
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Allergens, Diagnostics, and Therapeutic Aspects in House Dust Mite Allergy
Pages 415-428
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Cockroach, Tick, Storage Mite, and Other Arthropod Allergies: Molecular Aspects
Pages 429-444
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Mold Allergens and Their Importance in Molecular Allergy Diagnosis
Pages 445-458
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Latex Allergens: Source of Sensitization and Single Allergens
Pages 459-470
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Recombinant Allergens in Specific Immunotherapy
Pages 473-486
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Definition and Design of Hypoallergenic Foods
Pages 487-511
