Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Mitochondrial Function in Lung Health and Disease
Natarajan, Parinandi
Editore
Springer
Anno
2014
Pagine
222
ISBN
9781493908288
120,00 €
- Comprehensive, state-of-the-art review
- Written by experts in the field
- Covers both research and clinical issues
Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
Contents
1 Role of Mitochondrial Reactive Oxygen
and Nitrogen Species in Respiratory Diseases 1
Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha,
Narasimham L. Parinandi, and Viswanathan Natarajan
2 Regulation of Mitochondrial Functions by Transcription
Factor NRF2 27
Narsa M. Reddy, Wajiha Qureshi, Haranath Potteti,
Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy
3 Mitochondrion: A Missing Link in Asthma Pathogenesis 51
Ulaganathan Mabalirajan, Anurag Agrawal, and Balaram Ghosh
4 ROS Signaling in Cardiovascular Dysfunction
Associated with Obstructive Sleep Apnea . . . . . . . . . . . . . . . . . . . . . . 71
Ganesh K. Kumar, Gayatri Raghuraman, and Nanduri R. Prabhakar
5 Mitochondrial Excitation-Energy Coupling
in Airway Smooth Muscle 93
Niccole Schaible, Philippe Delmotte, and Gary C. Sieck
6 Mitochondrial Lipid Peroxidation in Lung Damage and Disease 117
Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang,
Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler,
Krishna Rao Maddipati, Viswanathan Natarajan,
and Narasimham L. Parinandi
7 The Impact of DNA Damage on Epithelial Cell
Maintenance of the Lung 141
Lidza Kalifa and Michael A. O’Reilly
8 Mitochondrial Function in Lung Health and Disease . 161
Luis Puente-Maestu and Jorge Chancafe-Morgan
9 Age-Specific Difference in Pulmonary Cellular Injury
and Mitochondrial Damage . 177
Katherine L. Tuggle and Michelle V. Fanucchi
Index . 215
