Mitochondrial Dysfunction in Neurodegenerative Disorders

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Mitochondrial Dysfunction in Neurodegenerative Disorders

Editore

Springer

Anno

2016

Pagine

380

ISBN

9783319286358

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.

Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins.

Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

An Introduction to Mitochondria, Their Structure and Functions

Simcox, Eve Michelle (et al.)

Pages 3-30
Neurodegeneration in Mitochondrial Disorders

Phillips, Jonathan (et al.)

Pages 33-58
The Ageing Brain, Mitochondria and Neurodegeneration

Hudson, Gavin

Pages 59-80
Mitochondrial Genes and Neurodegenerative Disease

Viscomi, Carlo (et al.)

Pages 81-106
Mitochondrial Signaling and Neurodegeneration

Picard, Martin (et al.)

Pages 107-137

Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson’s Disease

Surmeier, James (et al.)

Pages 141-173
Mitochondrial Dynamics and Neurodegeneration

Mourier, Arnaud

Pages 175-191
Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation

Sajic, Marija

Pages 193-217
Mitochondria, the Synapse, and Neurodegeneration

Chrysostomou, Alexia (et al.)

Pages 219-239
Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration

Ludtmann, Marthe H. R. (et al.)

Pages 241-253
Mitochondrial Degradation, Autophagy and Neurodegenerative Disease

Otten, Elsje G. (et al.)

Pages 255-278
The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria

Nguyen, Matthew (et al.)

Pages 279-300
Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?

Aradjanski, Marijana (et al.)

Pages 303-328
Mitochondrial Function and Dynamics Imaged In Vivo

Chisholm, Kim (et al.)

Pages 329-345
Development of Treatments and Therapies to Target Mitochondrial Dysfunction

Helliwell, Stephen B.

Pages 349-371
Summary and Conclusions

Reeve, Amy Katherine

Pages 373-376