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Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies.
	Volume 1
	SECTION A Basic Sciences Underlying Allergy and Immunology
	1 Innate Immunity
	2 Adaptive Immunity
	3 Immunoglobulin Structure and Function
	4 Immune Tolerance
	5 Cytokines in Allergic Inflammation
	6 Cellular Adhesion in Inflammation
	7 Chemokines
	8 The Complement System
	9 Lipid Mediators of Hypersensitivity and Inflammation
	10 Molecular Biology and Genetic Engineering
	11 Biology of Lymphocytes
	12 Innate Lymphoid Cells
	13 Antigen-Presenting Dendritic Cells
	14 Biology of Mast Cells and Their Mediators
	15 Biology of Basophils
	16 Biology of Eosinophils
	17 Biology of Neutrophils
	18 Biology of Monocytes and Macrophages
	19 Airway Epithelial Cells
	20 Airway Smooth Muscle
	21 Pathophysiology of Allergic Inflammation
	22 Genetics and Epigenetics in Allergic Diseases and Asthma
	CONTENTS
	23 Systems Biology
	24 Immunobiology of IgE and Its Receptors
	25 Neuronal Control of Airway Function in Allergy
	SECTION B Aerobiology and Allergens
	26 The Structure and Function of Allergens
	27 Aerobiology of Outdoor Allergens
	28 Indoor Allergens
	29 Preparation and Standardization of Allergen Extracts
	30 Air Pollution: Indoor and Outdoor
	31 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods
	SECTION C The Skin
	32 Structure of the Skin and Cutaneous Immunology
	33 Atopic Dermatitis
	34 Contact Dermatitis
	35 Urticaria and Angioedema
	36 Hereditary Angioedema and Bradykinin-Mediated Angioedema
	37 Immune Complex Mediated Diseases
	SECTION D The Eye
	38 Allergic and Immunologic Diseases of the Eye
	SECTION E Respiratory Tract
	39 The Nose and Control of Nasal Airflow
	40 Allergic and Nonallergic Rhinitis
	41 Rhinosinusitis and Nasal Polyps
	42 Development, Structure Lung and in Asthma
	43 Respiratory Tract Mucosal Immunology
	44 Airway Mucus and the Mucociliary System
	45 Epidemiology of Asthma and Allergic Diseases
	46 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma
	47 Asthma Pathogenesis
	48 Animal Models of Allergic Disease
	49 Diagnosis of Asthma in Infants and Children
	50 Management of Asthma in Infants and Children
	51 Diagnosis of Asthma in Adults
	52 Management of Asthma in Adolescents and Adults
	53 Emergency Treatment and Approach to the Patient with Acute Asthma
	54 Approach to the Patient with Exercise-Induced Bronchoconstriction
	55 Asthma and Allergic Diseases during Pregnancy
	56 Occupational Allergy and Asthma
	57 Pathology of Asthma
	58 Allergic Bronchopulmonary Aspergillosis Hypersensitivity Pneumonitis and Epidemic Thunderstorm Asthma
	59 Immunologic Nonasthmatic Diseases of the Lung
	60 Approach to the Patient with Chronic Cough
	61 Bronchial and Nasal Challenge Testing
	62 Lung Imaging
	63 Aerosols and Aerosol Drug Delivery Systems
	VOLUME 2
	SECTION F Gastrointestinal Tract
	64 Gastrointestinal Mucosal Immunology
	65 Eosinophilic Gastroenteropathies Disorders
	SECTION G Systemic Disease
	66 Clinical Significance of Immunoglobulin E
	67 In Vivo Methods for the Study and Diagnosis of Allergy
	68 Approach to the Patient with Recurrent Infections
	69 Primary Immunodeficiency Diseases
	70 Treatment of Primary Immunodeficiencies
	71 Human Immunodeficiency Virus and Allergic Disease
	72 Laboratory Tests for Allergic and Immunodeficiency Diseases
	73 Eosinophilia and Eosinophil-Related Disorders
	74 Mastocytosis
	75 Anaphylaxis
	76 Insect Allergy
	77 Drug Allergy
	78 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs
	79 Reactions to Foods
	80 Reactions to Additives in Foods in Drugs
	81 Oral Food Challenge Testing
	82 Food Allergy Management
	83 Adverse Reactions to Vaccines
	SECTION H Therapeutics
	84 Allergen Control for Prevention and Management of Allergic Diseases
	85 Injection Immunotherapy for Inhalant Allergens
	86 Sublingual Immunotherapy for Inhalant Allergens
	87 Principles of Pharmacotherapeutics
	88 Precision Medicine in Allergic Disorders
	89 Adherence
	90 Anti-Immunoglobulin E Therapy
	91 Cytokine-Specific Therapy in Asthma
	92 Histamine and Antihistamines
	93 Inhaled ß2-Agonists
	94 Theophylline and Phosphodiesterase Inhibitors
	95 Anticholinergic Therapies
	96 Glucocorticosteroids
	97 Antileukotriene Therapy in Asthma
	98 Unconventional Theories and Unproven Methods in Allergy
	99 Complementary and Alternative Medicine
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