Titolo: Methods and Biostatistics in Oncology

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Oncologia e Radioterapia

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Methods and Biostatistics in Oncology

Understanding Clinical Research as an Applied Tool

Editore

Springer

Anno

2018

Pagine

348

ISBN

9783319713236

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.

Brief History of the Scientific Method and Its Application in Oncology

Lima Vazquez, Vinicius, M.D., Ph.D. (et al.)

Pages 1-8
Generating a Hypothesis for an Oncology Study

Costa, Beatriz Teixeira (et al.)

Pages 9-22
Types of Variables and Distributions

Pond, Gregory R., Ph.D., P.Stat. (et al.)

Pages 23-35
Testing Measures of Associations

Paolino, Bruno S., M.D., Ph.D. (et al.)

Pages 37-49
Sample Size Calculation in Oncology Studies

Riechelmann, Rachel P., M.D., Ph.D. (et al.)

Pages 51-69

Interpretation of Results from Tables, Graphs, and Regressions in Cancer Research

Araújo, Raphael L. C., M.D., Ph.D. (et al.)

Pages 71-92
Survival Analysis

Haaland, Benjamin, Ph.D. (et al.)

Pages 93-124
The Role of Cross-Sectional and Cohort Studies in Oncology

Carvalho, André Lopes, M.D., Ph.D., M.P.H. (et al.)

Pages 125-146
Design of Retrospective and Case-Control Studies in Oncology

Panageas, Katherine S., Dr.P.H. (et al.)

Pages 147-164
How to Design Phase I Trials in Oncology

Carter, Louise, M.A., M.B.B.S., Ph.D., M.R.C.P. (et al.)

Pages 165-187
The Many Different Designs of Phase II Trials in Oncology

Riechelmann, Rachel P., M.D., Ph.D. (et al.)

Pages 189-202
Superiority and Non-inferiority Phase III Oncology Trials

Saad, Everardo D., M.D.

Pages 203-216
Phase IV Trials: Interventional and Non-interventional Studies

Uema, Deise, M.D. (et al.)

Pages 217-225
Identifying Bias in Clinical Cancer Research

Vera-Badillo, Francisco Emilio, M.D., M.Sc. (et al.)

Pages 227-240
Ethics in Clinical Cancer Research

Guindalini, Rodrigo Santa C., M.D., Ph.D. (et al.)

Pages 241-256
Cost-Effectiveness Studies in Oncology

Aguiar, Pedro, Jr., M.D. (et al.)

Pages 257-266
How to Undertake Outcomes Research in Oncology

Krzyzanowska, Monika K., M.D., M.P.H., F.R.C.P.C. (et al.)

Pages 267-286
Systematic Reviews and Meta-Analyses of Oncology Studies

Lima Pereira, Allan A., M.D., Ph.D. (et al.)

Pages 287-305
Meta-Research in Oncology

Saad, Everardo D., M.D. (et al.)

Pages 307-314
Analysis of Health-Related Quality of Life and Patient-Reported Outcomes in Oncology

King-Kallimanis, Bellinda L. (et al.)

Pages 315-342