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Epidemiology of Mesothelioma
Pages 1-18
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Mesothelioma
From Research to Clinical Practice
Ceresoli, Bombardieri, D'Incalci
Editore
Springer
Anno
2019
Pagine
340
ISBN
9783030168865
85,00 €
DA SCONTARE
This book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management.
Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease’s biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies.
This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas – e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials – and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.
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Asbestos and the Pathophysiology of Mesothelioma
Pages 19-33
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Screening Issues in Exposed Subjects and Early Diagnosis
Pages 35-43
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Genetics and Epigenetics of Mesothelioma
Pages 45-67
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Microenvironment and Immunology of the Human Pleural Malignant Mesothelioma
Pages 69-84
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Preclinical Models in Mesothelioma
Pages 85-98
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Pathological Diagnosis of Mesothelioma
Pages 99-122
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Tissue and Circulating Biomarkers in Mesothelioma
Pages 123-138
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Diagnostic Imaging of Mesothelioma
Pages 139-152
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Measuring Malignant Pleural Mesothelioma
Pages 153-166
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Role of Metabolic Imaging in Mesothelioma
Pages 167-175
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Staging of Malignant Pleural Mesothelioma
Pages 177-184
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Surgery and Multimodality Treatment in Malignant Pleural Mesothelioma
Pages 185-203
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Role of Radiotherapy in Malignant Pleural Mesothelioma
Pages 205-220
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Role of Chemotherapy in the Management of Malignant Pleural Mesothelioma
Pages 221-233
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Targeting Angiogenesis in Malignant Pleural Mesothelioma
Pages 235-242
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Targeted Therapies in Mesothelioma
Pages 243-259
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Mesothelin-Targeted Agents in Mesothelioma
Pages 261-269
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Immunotherapy of Mesothelioma: Vaccines and Cell Therapy
Pages 271-280
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Immunotherapy, the Promise for Future of Mesothelioma Treatment?
Pages 281-299
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Peritoneal Mesothelioma: Diagnosis and Management
Pages 301-322
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Rare Localizations of Mesothelioma
Pages 323-330
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Unmet Needs and Future Outlook of Mesothelioma Management
Pages 331-340
