.- Chapter 1. Melatonin: Its Physiology and Pharmacology .- Chapter 2. Past, Present and Future of Melatonin’s Clinical Uses.- Chapter 3. Melatonin’s Role in Mitochondrial Homeostasis: Health and Disease.- Chapter 4. Melatonin Receptors and their Role in Human Diseases.- Chapter 5. Melatonin as an Antioxidant: Mechanisms and Applications.- Chapter 6. Melatonin and Immune Function .- Chapter 7. Microbicidal Actions of Melatonin and its Clinical Use .- Chapter 8. Melatonin’s Role in Antinociceptive Mechanisms: Therapeutic Applications.- Chapter 9. Melatonin Antagonism as a Way for Therapeutic Application in Malaria..- Chapter 10. Melatonin in Human Reproductive Mechanisms.- Chapter 11. Melatonin’s Use in Oncology .- Chapter 12. Melatonin Use in Insomnia .- Chapter 13. Melatonin in Mood Disorders .- Chapter 14. Melatonergic Drugs in Sleep Disorders .- Chapter 15. Use of Agomelatine in Depressive Disorder .- Chapter 16. Agomelatine in Major Depressive Disorder: Efficacy, Safety and Tolerability.- Chapter 17. Melatonergic Antidepressant: It’s Use in Depressive Disorders .- Chapter 18. Melatonin Treatment for Children and Adults with ADHD and Sleep Disorders.- Chapter 19. Melatonin for Use in Children with Sleep Onset Insomnia.- Chapter 20. Melatonin in Parkinson’s Disease; Therapeutic Role.- Chapter 21. Role of Melatonin in Mood Disorders and Antidepressant Effects of Melatonin.- Chapter 22. Melatonin in Ocular Diseases.- Chapter 23. Melatonin in Jet Lag.- Chapter 24. Melatonin in Circadian Rhythm Sleep Disorders: Recent Developments