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History and Epidemiology
Pages 1-16
This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted.
Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.
History and Epidemiology
Pages 1-16
Initial Evaluation and Diagnosis of Medullary Thyroid Carcinoma
Pages 17-24
The Physiology of Serum Calcitonin and Carcinoembryonic Antigen in Medullary Thyroid Cancer
Pages 25-31
Cytology and Pathology: Pitfalls and Challenges
Pages 33-46
Molecular Mechanisms of Disease: The RET Proto-oncogene
Pages 47-63
Genetic Evaluation of the Patient with Medullary Thyroid Cancer
Pages 65-75
Preoperative Evaluation of the Patient with Medullary Thyroid Cancer
Pages 77-83
Inherited Medullary Thyroid Carcinoma: Indications and Technique of Early Thyroidectomy
Pages 85-94
Surgical Management of Inherited MTC: Therapeutic Thyroidectomy
Pages 95-102
Surgical Management of Parathyroid and Adrenal Glands in Inherited Medullary Thyroid Carcinoma
Pages 103-114
Surgical Management of Sporadic Medullary Thyroid Cancer (Extent of Thyroid Resection and the Role of Central and Lateral Neck Dissection)
Pages 115-126
Surgical Management of Invasive Medullary Thyroid Carcinoma
Pages 127-136
Importance of Thyroid Hormone Replacement Therapy in Patients with Medullary Thyroid Cancer
Pages 137-149
Medullary Thyroid Cancer: The Role of External Beam Therapy
Pages 151-155
Management of Patients with Metastatic Medullary Thyroid Carcinoma: The Role for Systemic Therapy
Pages 157-164
Ablative Therapies of the Liver and Bone in Medullary Thyroid Cancer
Pages 165-171
Emerging Therapies for Progressive Metastatic Medullary Thyroid Cancer
Pages 173-181
Follow-Up and Surveillance of Patients with Medullary Thyroid Carcinoma
Pages 183-188
Surgical Management of Recurrent Medullary Thyroid Cancer
Pages 189-197
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