Titolo: Manual of Cardiovascular Proteomics

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Manual of Cardiovascular Proteomics

Editore

Springer

Anno

2016

Pagine

430

ISBN

9783319318264

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments.
As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics.
In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

A Historical Perspective on Cardiovascular Proteomics

Agnetti, Giulio (et al.)

Pages 1-14
Basic Concepts in Mass Spectrometry and Protein Quantitation

Cosme, Jake (et al.)

Pages 15-32
How to Design a Cardiovascular Proteomics Experiment

Lindsey, Merry L. (et al.)

Pages 33-57
Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics

Miller, Mickey R. (et al.)

Pages 59-104
Vascular Proteomics

Martin-Ventura, Jose Luis (et al.)

Pages 105-122

Stem Cell Proteomics

Waas, Matthew (et al.)

Pages 123-153
Bottom-Up Proteomics

Silvestre, Dario (et al.)

Pages 155-185
Top-Down Proteomics

Lane, Nicole M. (et al.)

Pages 187-212
Targeted Proteomics (MRM) in Cardiovascular Research

Pimienta, Genaro (et al.)

Pages 213-226
Label-Free Quantification by Data Independent Acquisition Mass Spectrometry to Map Cardiovascular Proteomes

Parker, Sarah J. (et al.)

Pages 227-245
Labeling and Label-Free Shotgun Proteomics Quantification in the Research of Cardiovascular Diseases

Shen, Xiaomeng (et al.)

Pages 247-274
Analysis of Proteomic Data

Kammers, Kai (et al.)

Pages 275-292
Post-translational Modifications in the Cardiovascular Proteome

Murray, Christopher I. (et al.)

Pages 293-320
Proteomic Network Systems Analysis

Arrell, D. Kent (et al.)

Pages 321-342
Sensing and Remembering Cellular States Through Chromatin

Jiang, Shanxi (et al.)

Pages 343-363
Synergizing Proteomic and Metabolomic Data to Study Cardiovascular Systems

Gilda, Jennifer E. (et al.)

Pages 365-388
Clinical Cardiovascular Proteomics

Currie, Gemma (et al.)

Pages 389-414
Concluding Remarks: Proteomics AD 2025

Wright, Ian (et al.)

Pages 415-426