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This book, part of the European Society of Intensive Care Medicine (ESICM) textbook series, deals with dysregulated host response a relatively new term introduced by the Sepsis-3 definitions in 2016. In contrast to systemic inflammatory response syndrome (SIRS) that has been used for nearly 30 years, this is a fundamentally new concept, which requires some sort of a paradigm shift in the way of thinking of critical care physicians. This change obviously requires time and after 5 years, time is ripe to summarize the knowledge in the form of a comprehensive book.
The book is split in 4 sections. In the first one, the host immune response is explained in 11 chapters, followed by the next part, summarizing the possible tools for assessment at the bedside. The third and the fourth parts focus on the effects of dysregulated immune response on vital organ function and on the possible ways of immunomodulation. Written by internationally acclaimed experts of the field, the book is of value for all those intensivists and allied professionals working in ICUs.
Pages I-XXIII
Front Matter
Pages 1-1
Pages 3-18
The Dysregulated Host Response
Pages 19-34
Pages 35-54
Hemophagocytic Lymphohistiocytosis
Pages 55-84
Extracorporeal Circulation-Related Immune Response
Pages 85-112
Pages 113-133
Front Matter
Pages 135-135
Pro- and Anti-inflammatory Biomarkers
Pages 137-144
How to Interpret Procalcitonin?
Pages 145-150
Assessment of the Macro- and Microcirculation
Pages 151-167
Front Matter
Pages 169-169
Management of Dysregulated Immune Response in the Critically Ill: Heart and Circulation
Pages 171-188
Pages 189-202
Dysregulated Immune Response and Kidney Dysfunction
Pages 203-212
Dysregulated Immune Response and Organ Dysfunction: Liver
Pages 213-231
Pages 233-253
Dysregulated Immune Response and Organ Dysfunction: The Muscles
Pages 255-262
Front Matter
Pages 263-263
Pages 265-276
Anti-cytokine Therapy in Critical Illness: Is There a Role?
Pages 277-297
Extracorporeal Cytokine Removal
Pages 299-311
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