Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Lipoprotein(a)
Kostner, Kostner, Toth
Editore
Springer
Anno
2023
Pagine
443
ISBN
9783031245749
200,00 €
DA SCONTARE
Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited.
This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies.
Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
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Front Matter
Pages i-xvii
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60 Years of Lp(a) Research: From Ouchterlonys Double Diffusion to Copy Number Variation and a Significant Risk Factor for CHD
- Gerd Utermann
Pages 1-37
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Lp(a) Biochemistry, Composition, and Structure
- Gerhard M. Kostner
Pages 39-54
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Genetics of Lipoprotein(a)
- Gerd Utermann
Pages 55-73
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Lp(a) Metabolism
- John S. Millar, Daniel J. Rader
Pages 75-90
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Contemporary Aspects of Lp(a) Metabolism and Therapies Based on Tracer Kinetic Studies in Humans
- Dick C Chan, Jing Pang, Gerald F Watts
Pages 91-111
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Role of Proprotein Convertase Subtilisin Kexin Type 9 in Lipoprotein(a) Metabolism
- Antonio Gallo, Kévin Chemello, Romuald Techer, Ali Jaafar, Gilles Lambert
Pages 113-124
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The Role of Cell Surface Receptors in Lp(a) Catabolism
- Lamia Ismail, Déanna Shea, Sally McCormick
Pages 125-134
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Physiological Roles and Functions of Lipoprotein(a)
- Zaid N. Safiullah, Thorsten Leucker, Steven R. Jones, Peter P. Toth
Pages 135-158
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The Role of Lp(a) in Atherosclerosis: An Overview
- Anastasiya Matveyenko, Marianna Pavlyha, Gissette Reyes-Soffer
Pages 159-171
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Molecular Mechanisms of Lipoprotein(a) Pathogenicity: Tantalizing Clues and Unanswered Questions
- Michael B. Boffa, Marlys L. Koschinsky
Pages 173-187
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Thrombosis, Inflammation, and Lipoprotein(a): Clinical Implications
- Maya S. Safarova, Patrick M. Moriarty
Pages 189-206
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The Kidney Is the Heart of the Organs: Its Role in Lp(a) Physiology and Pathophysiology
- Hans Dieplinger
Pages 207-230
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Lp(a) as a Cardiovascular Risk Factor
- Angela Pirillo, Alberico Luigi Catapano
Pages 231-239
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Lp(a) and Aortic Valve Stenosis, Stroke, and Other Noncoronary Cardiovascular Diseases
- Anne Langsted, Pia R. Kamstrup
Pages 241-250
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Lipoprotein(a) in Cardiovascular Disease: Evidence from Large Epidemiological Studies
- Peter Engel Thomas, Signe Vedel-Krogh, Børge G. Nordestgaard
Pages 251-259
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Lipoprotein(a) and Immunity
- O. I. Afanasieva, T. I. Arefieva, M. V. Ezhov, S. N. Pokrovsky
Pages 261-274
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When Should We Measure Lipoprotein(a)?
- Karam Kostner
Pages 275-280
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Measurement of Lipoprotein(a) in the Clinical Laboratory
- David Sullivan, Catherine Woolnough, Nimalie Perera, Jay Ramanathan, Tony Badrick
Pages 281-295
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Standardization of Analytical Methods for the Measurement of Lipoprotein(a): Bridging Past and Future Initiatives
- Noemie Clouet-Foraison, Tomas Vaisar, Santica M. Marcovina
Pages 297-323
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On the Way to a Next-Generation Lp(a) Reference Measurement System Based on Quantitative Protein Mass Spectrometry and Molar Units
- Christa Cobbaert, Liesbet Deprez, Renee Ruhaak
Pages 325-346
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Therapy of Elevated Lipoprotein(a)
- S. Ibrahim, Erik S. G. Stroes
Pages 347-357
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Antisense Oligonucleotide Therapy to Treat Elevated Lipoprotein(a)
- Sotirios Tsimikas
Pages 359-375
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Lipoprotein Apheresis for Reduction of Lipoprotein(a)
- Ulrich Julius, Sergey Tselmin
Pages 377-407
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Elevated Lp(a): Why Should I Test For It, If I Cannot Treat It? A Patient’s Perspective
- Sandra Revill Tremulis
Pages 409-424
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Unresolved Questions
- Gerhard M. Kostner, Karam Kostner
Pages 425-435
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Correction to: The Kidney Is the Heart of the Organs: Its Role in Lp(a) Physiology and Pathophysiology
- Hans Dieplinger
Pages C1-C1
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Back Matter
Pages 437-443
