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Leong's Manual of Diagnostic Biomarkers for Immunohistology 4th Edition
Chetty, Cooper
Editore
Cambridge
Anno
2022
Pagine
532
ISBN
9781108491570
150,00 € 120,00 €

DA SCONTARE

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice. This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format. Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis. Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.

  •  
  • The fourth edition of the Manual of Diagnostic Biomarkers for Immunohistology, fully updated with new entries, providing practical guidance on preparation, key uses and pitfalls of antibodies for immunohistology
  • Seventeen high-quality full colour infographics present bite-sized detail about specific biomarkers pulling out important information about expression in tissues and prognosis
  • Highlights caveats and how to avoid the most common problems in practical application of immunohistochemistry
  • Each entry follows a standard structure for quick and easy access and retrieval of information

Contents
Cambridge University Press & Assessment
978-1-108-49157-0 — Leong's Manual of Diagnostic Biomarkers for Immunohistology
Edited by Runjan Chetty , Kumarasen Cooper , Carol Cheung , Srinivas Mandavilli
Table of Contents
More Information
www.cambridge.org© in this web service Cambridge University Press & Assessmentviii
Contents
CDX2 (caudal type homeobox 2) 147
c-erbB-2 (Her2, neu, CD340) 149
Chlamydia 151
Chromogranin 153
Claudin-5 155
c-Myc 157
Collagen type IV 159
CXCL13 161
Cyclin D1 (bcl-1) 163
Cytokeratins 165
Cytokeratin 5/6 (CK 5/6) 169
Cytokeratin 7 (CK 7) 171
Cytokeratin 19 (CK 19) 173
Cytokeratin 20 (CK 20) 175
Cytokeratins: 34βE12 177
Cytokeratins: AE1/AE3 179
Cytokeratins: CAM 5.2 181
Cytokeratins: MAK-6 183
Cytokeratins: MNF 116 185
Cytomegalovirus (CMV) 187
Cytotoxic molecules (TIA-1, granzyme B, perforin) 189
D2-40 191
DBA.44 (hairy cell leukemia) 193
Deleted in pancreatic cancer locus 4 (DPC4/SMAD4) 195
Desmin 197
Desmoplakins 199
DOG-1 201
E-cadherin/N/97-cadherin 203
Epidermal growth factors: TGF-α and EGFR 205
Epithelial membrane antigen 207
Epstein–Barr virus, LMP 209
ERG (avian v-ets erythroblastosis virus E26 oncogene
homolog) 211
Erythropoietin 213
Estrogen receptor (ER) 215
Factor VIII RA (von Willebrand factor) 217
Factor Xllla 219
Fas (CD95) and Fas-ligand (CD95 L) 221
Fascin 223
Ferritin 225
Fibrin 227
Fibrinogen 229
Fibronectin 231
FLI-1 protein 233
FOXL2 235
GATA 3 binding protein 3 (GATA3) 237
Glial fibrillary acidic protein (GFAP) 239
Glut-1 241
Glypican-3 243
Gross cystic disease fluid protein-15 (GCDFP-15,
BRST-2) 245
H3K27 M
HAM56 (macrophage marker) 249
HBME-1 (mesothelial cell marker) 251
h-Caldesmon 253
Heat shock proteins (HSPs) 255
Helicobacter pylori 257
Hep Par 1 (hepatocyte marker) 259
Hepatitis B core antigen (HBcAg) 261
Hepatitis B surface antigen (HBsAg) 263
Herpes simplex virus I and II (HSV I and II) 265
HHV-8 (human herpesvirus 8) 267
HLA-DR 269
HMB-45 (melanoma marker) 271
hMLH1 and hMSH2 (mismatch repair proteins) 273
Human immunodeficiency virus (HIV) 275
Human milk fat globule (HMFG) 277
Human papilloma virus (HPV) 279
Human parvovirus B19 281
Human placental lactogen (hPL) 283
IDH1 and IDH2 (isocitrate dehydrogenase 1 and 2) 285
IgG4 287
Immunoglobulins: Igκ, Igλ, IgA, IgD, IgE, IgG, IgM 289
Inhibin 291
Insulinoma-associated 1 293
Islet1 295
Ki-67 (MIB1, Ki-S5) 297
Laminin 299
Lysozyme (muramidase) 301
MAC 387 303
MART-1/Melan-A 305
Maspin 307
MDM-2 309
Measles 311
Mel-CAM (melanoma cell adhesion molecule,
CD146) 313
Mesothelin 315
Metallothioneins 317
Microphthalmia transcription factor (MiTF) 319
Mitochondria 321
MLH1/MSH2 proteins 323
MOC-31 327
MSH6 329
MUC2 (mucin 2) 331
MUC4 333
MUC5AC 335
MUC6 337
MUM-1 (interferon response factor 4, IRF4) 339
Muscle-specific actin (MSA) 341
Mycobacterial antigen 343
Myelin basic protein (MBP) 345
Myeloperoxidase 347
Cambridge University Press & Assessment
978-1-108-49157-0 — Leong's Manual of Diagnostic Biomarkers for Immunohistology
Edited by Runjan Chetty , Kumarasen Cooper , Carol Cheung , Srinivas Mandavilli
Table of Contents
More Information
www.cambridge.org© in this web service Cambridge University Press & Assessmentix
Contents
MyoD1 349
Myogenin 351
Myoglobin 353
Napsin-A 355
Neurofilaments 357
Neutrophil elastase 359
NKX2.2 361
nm23/NME1 363
NTRK 365
OCT2 (POU2F2) 367
OCT4 369
OLIG2 (oligodendrocyte transcription factor 2) 371
Osteopontin 373
p16 375
p27kip1 377
p40 379
p53 381
p63 383
Pancreatic hormones (insulin, somatostatin, vasoactive
intestinal polypeptide, gastrin, glucagon, pancreatic
polypeptide) 385
Parathyroid hormone 387
Parathyroid hormone-related protein (PTHrP) 389
PAX-2 (paired box gene 2) 391
PAX-5 393
PAX-8 395
PDX1 397
P-glycoprotein (P-170), multidrug resistance (MDR) 399
Phosphohistone H3 (pHH3) 401
Pituitary hormones (ACTH, FSH, hGH, LH, PRL, TSH) 403
Placental alkaline phosphatase (PLAP) 405
PMS2 407
Pneumocystis carinii 409
Pregnancy-specific β-1-glycoprotein (SP1) 411
Progesterone receptor (PR) 413
Programmed death-1 415
Proliferating cell nuclear antigen (PCNA) 417
Prostate-specific antigen (PSA) 419
Prostatic acid phosphatase (PAP) 421
pS2 423
PTEN (phosphatase and tensin homolog deleted on
chromosome 10) 425
Rabies 427
Retinoblastoma gene protein (P110Rb,
Rb protein) 429
S100 431
SALL4 433
SATB2 435
Serotonin 437
SF-1 439
Simian virus 40 (SV40 T antigen) 441
SMARCA4/BRG-1 443
SMARCB1 445
Smooth muscle actin (SMA) 447
Smooth muscle myosin heavy chain 449
SOX9 451
SOX10 453
Spectrin/Fodrin 455
STAT6 457
Surfactant apoprotein-A 459
Synaptophysin 461
TAG 72 (B72.3) 463
Tau 465
TCL1 467
Tenascin 469
Terminal deoxynucleotidyl transferase (TdT) 471
TFE3 473
Thrombomodulin 475
Thyroglobulin 477
Thyroid transcription factor-1 (TTF-1) 479
TLE1 481
Topoisomerase II alpha 483
Toxoplasma gondii 485
Tyrosinase 487
Tyrosine hydroxylase 489
Ubiquitin 491
Ulex europaeus agglutinin 1 lectin (UEA-I) 493
VEGF (vascular endothelial growth factor) 495
Villin 497
Vinculin 499
VS38 501
WT1 503

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