Informazioni
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History of the J Wave and J Wave Syndromes
Pages 1-14
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
J Wave Syndromes
Brugada and Early Repolarization Syndromes
Antzelevitch, Yan
Editore
Springer
Anno
2016
Pagine
327
ISBN
9783319315768
157,00 €
DA SCONTARE
This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics.
J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes.
There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.
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J Wave Syndromes: From Bench to Bedside
Pages 15-32
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Ionic and Cellular Mechanisms Underlying J Wave Syndromes
Pages 33-76
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Genetic Basis of Early Repolarization Syndrome
Pages 77-90
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J Wave Syndrome-Susceptibility Mutations Versus Benign Rare Variants: How Do We Decide?
Pages 91-120
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Prevalence and Clinical Characteristics of Brugada Syndrome
Pages 121-138
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Update on the Differential Diagnosis and Treatment of Brugada Syndrome
Pages 139-172
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Risk Stratification in Brugada Syndrome: Clinical Characteristics, Electrocardiographic Parameters and Auxiliary Testing
Pages 173-191
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Prevalence and Risk Stratification of Patients with Electrocardiographic Pattern of Early Repolarization
Pages 193-206
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Prognostic Value of Early Repolarization Pattern in Development of VT/VF in Ischemic Heart Disease, Hypothermia, Etc.
Pages 207-232
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Similarities and Differences in the Electrocardiographic and Clinical Features Between Early Repolarization Syndrome and Brugada Syndrome
Pages 233-244
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Atrial Arrhythmias Associated with J Wave Syndromes
Pages 245-258
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Phenotypic Expression and Genetics of J Wave Syndrome in the Early Stage of Arrhythmogenic Right Ventricular Cardiomyopathy
Pages 259-280
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Clinical Features of Electrical Storms Associated with J Wave Syndromes and Acquired Forms of J Wave Syndrome
Pages 281-300
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Therapy for J Wave Syndromes
Pages 301-318
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J Wave Syndromes in China
Pages 319-324
