Preface

Section I Pathogenesis and Clinical Features

1 Epidemiology and Pathogenesis

Clinical Take Home Messages

Epidemiology

Pathogenesis

Genetics

Microbiome

Environmental Triggers

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

2 Clinical Features and Diagnosis of Crohn’s Disease 

Clinical Take Home Messages 

Clinical Features 

Disease Course and Natural History 

Diagnosis 

History and Physical Examination 

Laboratory Investigations 

Serologic Markers 

Endoscopy 

Histology 

Imaging Studies 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

3 Clinical Features and Diagnosis of Ulcerative Colitis 

Clinical Take Home Messages 

Clinical Features 

Disease Course and Natural History 

Diagnosis 

History and Physical Examination 

Laboratory Investigations 

Serologic Markers 

Endoscopy 

Histology 

Imaging Studies 

Differential Diagnosis (UC and CD) 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

4 Extraintestinal Manifestations of Inflammatory Bowel Diseases 

Clinical Take Home Messages 

Arthritis and Arthropathy 

Metabolic Bone Disease 

Cutaneous Manifestations 

Hepatobiliary Manifestations 

Ophthalmologic Manifestations 

Renal Complications 

Thromboembolic and Cardiovascular Complications 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

Section II Therapeutic Agents

5 Aminosalicylates 

Clinical Take Home Messages 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Safety 

Multiple Choice Questions 

References 

Answers to Questions 

6 Corticosteroids 

Clinical Take Home Messages 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Safety 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

7 Immunomodulators 

Clinical Take Home Messages 

Thiopurines 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Safety 

Methotrexate 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Safety 

Calcineurin Inhibitors 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

8 Biologic Therapies 

Clinical Take Home Messages 

Infliximab 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Safety 

Adalimumab 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Certolizumab Pegol 

Efficacy in Crohn’s Disease 

Golimumab 

Natalizumab 

Vedolizumab 

Newer Therapies 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

9 Antibiotics 

Clinical Take Home Messages 

Efficacy in Ulcerative Colitis 

Efficacy in Crohn’s Disease 

Other Microbial Modification Methods – Probiotics and Fecal Microbiota

Transplantation 

Multiple Choice Questions 

References 

Answers to Questions 

Section III Management 

10 Medical Management of Ulcerative Colitis 

Clinical Take Home Messages 

Assessment of Extent, Activity, and Severity 

Limited Colitis – Proctitis, Proctosigmoiditis, and Left ]sided Colitis 

Pancolitis 

Mild to Moderate Disease 

Moderate to Severe Disease 

Severe Disease 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

11 Medical Management of Crohn’s Disease 

Clinical Take Home Messages 

Mild to Moderate Disease 

Moderate to Severe Disease 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

12 Surgical Management of Inflammatory Bowel Diseases

Clinical Take Home Messages 

Surgery for Ulcerative Colitis 

Pouch ]related Complications in Ulcerative Colitis 

Surgery for Crohn’s Disease 

Prophylaxis for Prevention of Postoperative Recurrence in Crohn’s Disease 

Case Studies and Multiple Choice Questions 

References 

Recommended Reading 

Answers to Questions 

13 Complications of Inflammatory Bowel Diseases 

Clinical Take Home Messages 

Complications of Ulcerative Colitis 

Toxic Megacolon and Perforation 

Colonic Strictures 

Clostridium difficile and Cytomegalovirus Colitis 

Colorectal Dysplasia and Cancer 

Magnitude and Risk Factors 

Surveillance for Dysplasia and Cancer 

Management of Dysplasia 

Chemoprevention 

Complications of Crohn’s Disease 

Fibrostenosis and Strictures 

Abscesses 

Fistulizing Crohn’s Disease 

Small ]bowel Cancer 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

Section IV Special Considerations 

14 Nutrition in Inflammatory Bowel Diseases 

Clinical Take Home Messages 

Malnutrition and Micronutrient Deficiencies 

Dietary Therapies for Inflammatory Bowel Diseases 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

15 Pregnancy, Conception, and Childbirth 

Clinical Take Home Messages 

Fertility 

Effect of Pregnancy on Disease 

Effect of Disease on Pregnancy 

Maternal Medication Use During Pregnancy 

Paternal Medication Use 

Inheritance 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

16 Inflammatory Bowel Disease During Childhood and Adolescence 

Clinical Take Home Messages 

Epidemiology and Clinical Features 

Treatment of Pediatric Inflammatory Bowel Disease 

Very Early ]onset Inflammatory Bowel Disease 

Transition of Care in Pediatric Crohn’s Disease 

Case Studies and Multiple Choice Questions 

References 

Answers to Questions 

Index