Immunotherapy for Pediatric Malignancies

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Immunologia e Allergologia

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Immunotherapy for Pediatric Malignancies

Editore

Springer

Anno

2018

Pagine

297

ISBN

9783319434841

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.

Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.

Introduction to Pediatric Cancer Immunotherapy

Marabelle, Aurélien, M.D., Ph.D. (et al.)

Pages 1-11
Overcoming Immune Suppression in the Tumor Microenvironment: Implications for Multi-modal Therapy

Johnson, Theodore S., M.D. (et al.)

Pages 13-38
Allogeneic Stem Cell Transplantation

Schlegel, Patrick, M.D. (et al.)

Pages 39-64
Overview of Monoclonal Antibody Therapies

Gray, Juliet C., M.A., FRCPCH, Ph.D. (et al.)

Pages 65-78
Monoclonal Antibodies Targeting Hematological Malignancies

Barth, Matthew J., M.D. (et al.)

Pages 79-116

Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours

Lode, Holger N., M.D.

Pages 117-139
Monoclonal Antibodies Targeting the Immune System

Minard-Colin, Véronique, M.D., Ph.D.

Pages 141-160
Adoptive T Cell Therapies for Children’s Cancers

Fisher, Jonathan (et al.)

Pages 161-174
NK Cell and NKT Cell Immunotherapy

DeSantes, Kenneth, M.D. (et al.)

Pages 175-215
Cancer Vaccines in Pediatrics

Nakajima, Miho, M.D. (et al.)

Pages 217-242
Immune Adjuvants and Cytokine Therapies

Pistoia, Vito, M.D. (et al.)

Pages 243-257
Immune Biomarkers in Paediatric Malignancies

Semeraro, Michaela (et al.)

Pages 259-273
Future Perspectives

Marabelle, Aurelien, M.D., Ph.D. (et al.)

Pages 275-289