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Evolution in the Concept of Focal Therapy: The Story of Breast Cancer and Prostate Cancer
Pages 3-19
This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation.
Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients.
Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.
Evolution in the Concept of Focal Therapy: The Story of Breast Cancer and Prostate Cancer
Pages 3-19
Targeted Therapy for Localized Kidney Cancer
Pages 21-38
Focal Therapy for Prostate Cancer: A Guide for Patients
Pages 39-48
Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy
Pages 51-56
Focal Therapy and Active Surveillance in Europe
Pages 57-74
Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia
Pages 75-81
Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology
Pages 85-104
Identifying and Characterizing the Index Lesion
Pages 105-113
Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients
Pages 115-128
Patient Selection for Focal Therapy of Prostate Cancer
Pages 129-137
Prostate Focal Therapy: Definitions and Common Terminology
Pages 139-144
Reading and Reporting Standards: The Prostate Imaging Reporting and Data System—What Is It and What Can It Do?
Pages 147-159
Role of Magnetic Resonance Imaging in Prostate Cancer Assessment
Pages 161-176
Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement
Pages 177-192
Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology
Pages 193-202
In-Bore Magnetic Resonance Imaging-Targeted Prostate Biopsy
Pages 205-218
Multiparametric MRI/TRUS Fusion Biopsy, Outcomes, and Commercial Systems
Pages 219-237
Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping
Pages 239-250
Multiparametric Transrectal Ultrasound Biopsy
Pages 251-263
Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy
Pages 265-273
In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation
Pages 277-282
Focal Cryotherapy
Pages 283-291
Photodynamic Therapy for Early Prostate Cancer
Pages 293-306
High-Intensity Focused Ultrasound
Pages 309-323
Transrectal Laser Focal Therapy of Prostate Cancer
Pages 325-343
Focal Therapy for Prostate Cancer: A Molecular Biology Approach with TRAIL
Pages 347-354
Focal Brachytherapy and Intensity-Modulated Radiation Therapy
Pages 355-371
Focal Therapy for Anterior Cancers (Originated from Transition Zone)
Pages 373-382
The Story of Adjuvants to Boost the Performance of Cryoablation
Pages 385-397
5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy
Pages 399-405
Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control
Pages 409-416
Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer
Pages 417-429
Posttreatment Surveillance Using Multiparametric Magnetic Resonance Imaging
Pages 431-441
Determining Focal Therapy Failure and Salvage Options
Pages 443-446
Positioning Focal Therapy from Consensus to Guidelines
Pages 447-463
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