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IgG4-Related Disease: History and Overview
Pages 3-24
This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.
IgG4-Related Disease: History and Overview
Pages 3-24
IgG4-Related Disease: Pathological Features and Differential Diagnosis
Pages 25-41
Potential Pathways in the Pathogenesis of IgG4-Related Disease
Pages 43-54
Does IgG4-Related Disease Have an Autoimmune Basis?
Pages 55-63
Plasmablasts: A Promising Biomarker in IgG4-Related Disease
Pages 65-72
Overview of IgG4-Related Kidney Disease
Pages 75-83
IgG4-Related Kidney Disease: Clinical and Laboratory Features
Pages 85-96
Imaging Findings
Pages 97-104
Characteristic Tubulointerstitial Nephritis in IgG4-Related Kidney Disease
Pages 105-113
Electron Microscopic Findings
Pages 115-123
IgG4-Related Kidney Disease: Pathological Features: Membranous Glomerulonephritis
Pages 125-137
IgG4-Related Kidney Disease: Pathological Features: Other Glomerular Disease
Pages 139-143
IgG4-Related Kidney Diseases and Conditions: Renal Pelvic and Ureteral Diseases
Pages 145-157
Retroperitoneal Fibrosis/Periaortitis and Hydronephrosis
Pages 159-171
Other Urogenital Lesions (Testis, Paratesticular Lesion, Bladder, Prostate etc.)
Pages 173-185
Characteristic Distribution of Inflammatory Lesions in IgG4-Related Kidney Disease: Findings from Autopsy Case Series
Pages 187-191
Diagnosis of IgG4-Related Kidney Disease
Pages 193-201
Pathogenesis of IgG4-Related Kidney Disease
Pages 203-215
Corticosteroid Therapy for IgG4-Related Kidney Disease
Pages 219-227
Targeting the B Cell Lineage in IgG4-Related Disease
Pages 229-234
Differential Diagnosis of IgG4-Related Tubulointerstitial Nephritis: An Overview
Pages 237-250
Differential Diagnosis (1): ANCA Associated Vasculitis
Pages 251-260
Differential Diagnosis (2): Castleman Disease
Pages 261-269
Differential Diagnosis (3): Sjögren Syndrome
Pages 271-277
Differential Diagnosis: Lupus Nephritis and IgG4-Related Kidney Disease
Pages 279-289
Multicentric Castleman’s Disease Mimicking IgG4-Related Disease: A Case Report
Pages 293-301
A Case of Concurrent IgG4-Related Kidney Disease and Lupus Nephritis
Pages 303-311
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