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Introduction
Pages 3-5
This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer.
In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer.
This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.
Introduction
Pages 3-5
Induction of Oxidative Stress by Hyperthermia and Enhancement of Hyperthermia-Induced Apoptosis by Oxidative Stress Modification
Pages 7-18
Molecular Damage: Hyperthermia Alone
Pages 19-32
Roles of HSF1 and Heat Shock Proteins in Cancer
Pages 33-48
Cellular Responses in Signal Transduction Pathways Induced by Hyperthermia
Pages 49-60
Cell Cycle Responses to Hyperthermia
Pages 61-75
Thermo-Tolerance
Pages 77-81
Enhancement of Hyperthermia on Radio-Sensitivity
Pages 83-90
Inhibition of DNA Repair System Activity
Pages 91-108
Enhancement of Hyperthermia on Anti-tumor Drug Sensitivity
Pages 109-114
Inhibition of Epithelial-to-Mesenchymal Transition (EMT) by Hyperthermia
Pages 115-124
Potentiating Immune System by Hyperthermia
Pages 127-135
Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses
Pages 137-150
Tumor Microenvironment and Hyperthermia
Pages 151-169
Hyperthermia Alone
Pages 173-176
Combination Therapy with Hyperthermia and Chemoradiotherapy: Oral Cancer
Pages 177-191
Combination by Hyperthermia and Radiation (and Chemotherapy): Lung Cancer
Pages 193-200
Efficacy of Hyperthermia in Combination with Radiation Therapy for Breast Cancer
Pages 201-207
Combination by Hyperthermia and Radiation: Esophageal Cancer
Pages 209-213
Combination by Hyperthermia and Radiotherapy and/or Chemo-radiotherapy: Gyneology Cancer
Pages 215-226
Combination by Hyperthermia and Radiation and Chemotherapy: Soft Tissue Sarcoma
Pages 227-243
Combination by Hyperthermia and Chemotherapy: Lung Cancer
Pages 245-248
Efficacy of Hyperthermia in Combination With Chemotherapy for Breast Cancer
Pages 249-255
Combination by Hyperthermia and Chemotherapy: Esophageal Cancer
Pages 257-259
Combination with Hyperthermia and Chemotherapy: Liver Cancer
Pages 261-274
Hyperthermia Combined with Chemotherapy: Pancreatic Cancer
Pages 275-285
Effect of Hyperthermia in Combination with Chemotherapy and Radiation Therapy for Treatment of Urological Cancer: Prostate Cancer and Urothelial Cancer
Pages 287-294
Combination by Hyperthermia and Surgery
Pages 295-308
Combining Hyperthermia and Immunotherapy: NK Therapy and Hyperthermia
Pages 309-318
Combination by Hyperthermia and Immunotherapy: DC Therapy and Hyperthermia
Pages 319-327
Effects of Fever-Range Hyperthermia on T Cell-Mediated Immunity: Possible Combination of Hyperthermia and T Cell-Based Cancer Immunotherapy
Pages 329-340
Combination of Hyperthermia and Immunotherapy: Hyperthermia and Naïve T-cell Therapy
Pages 341-353
High-Temperature Hyperthermic Intraperitoneal Chemotherapy (H-HIPEC) with Cytoreductive Surgery for Patients with Peritoneal Metastases of Colorectal Cancer and Appendiceal Pseudomyxoma
Pages 355-369
A New Comprehensive Treatment for Peritoneal Metastases Using Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemoperfusion
Pages 371-396
Noninvasive Temperature Monitoring
Pages 397-420
Development of Heating Device
Pages 421-437
Epilogue
Pages 439-444
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