Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Huntington's Disease
Fourth Edition
Bates, Tabrizi, Jones
Editore
Oxford
Anno
2014
Pagine
521
ISBN
9780199929146
138,00 €
- About this book
- The only technical monograph dedicated to Huntington's disease
- Coverage of all aspects of the disease, including clinical presentation, basic scientific research, diagnostics, comprehensive care, and development of therapeutics and clinical trials
This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002.
Completely updated and expanded, chapters in this volume are organized in five sections:
· Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages
· The genetics of Huntington's disease, including new information on its epidemiology discussions of new testing guidelines
· Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry
· The molecular biology of Huntington's disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntington's disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology
· An updated description of the comprehensive care for Huntington's disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials.
Table of Contents
Section 1: Clinical aspects of Huntington's disease
1. Huntington's Disease in a Historical Context
Peter S Harper
2. Clinical Neurology of Huntington's disease
Raymund AC Roos
3. Neuropsychiatry and Neuropsychology
David Craufurd and Julie Snowden
4. Juvenile Huntington's disease
Oliver W J Quarrell
5. Premanifest and Early Huntington's Disease
Edward J Wild and Sarah J Tabrizi
Section 2: The genetics of Huntington's disease
6. Huntington's disease: genetic and molecular studies
Cécile Cazeneuve and Alexandra Durr
7. The Epidemiology of Huntington's Disease
Chris Kay, Emily Fisher, Michael R. Hayden
8. Genetic Counselling and Testing
Rhona MacLeod and Aad Tibben
Section 3: Neurobiology
9. The Neuropathology of Huntington's Disease in the Human Brain
Henry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, and Richard LM Faull
10. Altered Neuronal Circuitry in Huntington's Disease
Michael S. Levine, Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Véronique M. André
Section 4: The molecular biology of Huntington's disease
11. The normal function of huntingtin
Chiara Zuccato and Elena Cattaneo
12. Order, disorder, and conformational flux in the structural biology of Huntington's Disease
Ronald Wetzel and Rakesh Mishra
13. Pathogenic mechanisms in Huntington's disease
Alis Hughes and Lesley Jones
14. Peripheral pathology in Huntington's disease
Authors: Jorien M.M. van der Burg, N. Ahmad Aziz, Maria Björkqvist
Section 5: Therapeutic interventions in Huntington's disease
15. Comprehensive care in Huntington's disease
Martha A. Nance
16. Preclinical Experimental Therapeutics in Huntington's Disease
Gillian P. Bates and Christian Landles
17. Experimental Therapeutics in Huntington's Disease: Moving Forward in Clinical Trials
Beth Borowsky and Cristina Sampaio
