Titolo: Histiocytic Disorders

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Histiocytic Disorders

Editore

Springer

Anno

2018

Pagine

392

ISBN

9783319596310

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This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.
Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Pathology of Histiocytic Disorders and Neoplasms and Related Disorders

Picarsic, Jennifer, MD (et al.)

Pages 3-50
Biology and Genomics of LCH and Related Disorders

Rollins, Barrett J., MD, PhD

Pages 53-71
Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

Adam, Etai, MD (et al.)

Pages 73-85
Central Nervous System Langerhans Cell Histiocytosis

Minkov, Milen, MD, PhD (et al.)

Pages 87-101
First-Line Treatment of Pediatric Langerhans Cell Histiocytosis

Rodriguez-Galindo, Carlos, MD (et al.)

Pages 103-118

Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children

Abla, Oussama, MD (et al.)

Pages 119-137
Adult Langerhans Cell Histiocytosis

Girschikofsky, Michael, MD (et al.)

Pages 139-153
Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy

Nanduri, Vasanta, MD, MRCP, FRCPCH (et al.)

Pages 155-170
Classification, Clinical Manifestations, and Diagnostics of HLH

Schmid, J. Pachlopnik, MD, PhD (et al.)

Pages 173-187
CNS Involvement in HLH (CNS-HLH)

Horne, AnnaCarin, MD, PhD (et al.)

Pages 189-196
Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis

Saint Basile, Geneviève, MD, PhD (et al.)

Pages 197-214
Hemophagocytic Lymphohistiocytosis Associated with Malignancies and with Epstein-Barr Virus

Lehmberg, Kai, MD (et al.)

Pages 215-231
Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)

Grom, Alexei A., MD (et al.)

Pages 233-246
Treatment of Newly Diagnosed HLH and Refractory Disease

Henter, Jan-Inge, MD, PhD (et al.)

Pages 247-263
Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic Lymphohistiocytosis

Scott Baker, K., MD, MS (et al.)

Pages 265-274
HLH in Adults

Rosée, Paul, MD (et al.)

Pages 275-290
Juvenile Xanthogranuloma and Related Non-LCH Disorders

Ceppi, Francesco, MD (et al.)

Pages 293-311
Erdheim-Chester Disease

Diamond, Eli L., MD (et al.)

Pages 313-338
Rosai–Dorfman Disease

Abla, Oussama, MD (et al.)

Pages 339-360
Malignant Histiocytoses

Jacobsen, Eric, MD (et al.)

Pages 361-381
Erratum to: Histiocytic Disorders

Abla, Oussama (et al.)

Pages E1-E1