HEMOSTASIS AND THROMBOSIS:BASIC PRINCIPLES AND CLINICAL PRACTICESIXTH EDITION

Part 1: Introduction to the Field of Hemostasis and Thrombosis

Chapter 1.  History of the Field

William C. Aird and Gilbert C. White, II

Chapter 2.  Molecular Evolution of the Vertebrate Blood Coagulation System

Marianne A. Grant and William C. Aird

Chapter 3.  Molecular and Clinical Genetics

Lesley Everett, Karl C. Desch, and David Ginsburg

Chapter 4:  Coagulation Enzymology

Sriram Krishnaswamy

Chapter 5: Cell Biology, Protein Processing, and Cell Signaling

Randal J. Kaufman and Laura Popolo

Chapter 6: Cellular and Molecular Immunology

Andrew H. Lichtman

Chapter 7:  Biostatistics and Epidemiology: The Basic Science of Clinical Research

Kerry L. Lee

PART II: BASIC HEMOSTASIS AND THROMBOSIS

SECTION A: COAGULATION & FIBRINOLYSIS

Chapter 8: Overview of Basic Coagulation and Fibrinolysis

Gilbert C. White, II, Victor J. Marder, Sam Schulman, William C. Aird, and Joel S. Bennett

Chapter 9:  The Blood Coagulation Factors and Inhibitors: Complementary DNAs, Genes and Expression

Dominic W. Chung, Wengfeng Xu, and Earl W. Davie

Chapter 10: Genetics of Coagulation Proteins

Rodney M. Camire and Paris Margaritis

Chapter 11: Tissue Factor and the Initiation and Regulation (TFPI) of Coagulation

George J. Broze, Jr. and James H. Morrissey

Chapter 12: Factors V and VIII

Randal J. Kaufman, Philip J. Fay, Laura Popolo, and Thomas L. Ortel

Chapter 13: Structure and Function of von Willebrand Factor

Sandra L. Haberichter and Robert R. Montgomery

Chapter 14: Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins

Kanagasabai Vadivel, Amy E. Schmidt, Victor J. Marder, Sriram Krishnaswamy, and S. Paul Bajaj

Chapter 15A:  Factor XI

Peter N. Walsh and David Gailani

Chapter 15B: The Factor XII-driven Plasma Contact System

Thomas Renne

Chapter 16:  Fibrinogen Structure and Function

John W. Weisel and Carl-Erik Dempfle

Chapter 17: Factor XIII

Cédric Duval, Helen Philippou, and Robert A. S. Ariëns

Chapter 18: Antithrombin and the Serpin Family

Susan C. Bock

Chapter 19:  Protein C and S and Thrombomodulin System

Laurent O. Mosnier and John H. Griffin

Chapter 20: Plasminogen Activation and Regulation of Fibrinolysis

Nuala A. Booth and Nicola J. Mutch

Chapter 21:  Inhibitors of Fibrinolysis

Björn Wiman and Anna Ågren

SECTION B: PLATELET BIOLOGY

Chapter 22: Overview of Platelet Structure and Function

Joel S. Bennett and Gilbert C. White, II

Chapter 23:  Platelet Production: Cellular and Molecular Regulation

Elisabeth Cramer Bordé and William Vainchenker

Chapter 24: Megakaryocyte Structure and Platelet Biogenesis

Joseph E. Italiano, Jr. and John H. Hartwig

Chapter 25:  Thrombopoietin

Kenneth Kaushansky and Ian Hitchcock 

Chapter 26A: Major Platelet Glycoproteins: GPIb-IX-V

Michael C. Berndt, and Robert K. Andrews

Chapter 26B: Major Platelet Glycoproteins: GPIIb/IIIa

Feng Ye and Mark H. Ginsberg

Chapter 27:  Platelet Glycoprotein Polymorphisms and Relationship to Function and Immunogenicity

Thomas J. Kunicki and Diane J. Nugent

Chapter 28: The Basis for Platelet Adhesion

Brian Savage and Zaverio M. Ruggeri

Chapter 29: Shear Effects on Platelets and the Vessel Wall in the Pathogenesis of Atherothrombosis

David L. Bark Jr., Warwick S. Nesbitt, Angus K.T. Wong, and Shaun P. Jackson

Chapter 30: Platelets and Collagen

Steve P Watson, Richard W Farndale, Masaaki Moroi, and Stephanie M Jung

Chapter 31: Integrin αIIb β3 and Platelet Aggregation

Ana Kasirer-Friede, Kamila Bledzka, Jun Qin, , Edward F. Plow, and Sanford J. Shattil

Chapter 32:  Molecular Basis for Platelet Secretion

Shaojing Ye and Sidney W. Whitehart

Chapter 33: Platelet Signal Transduction

Charles S. Abrams and Lawrence F. Brass 

Chapter 34:  Platelet Prostaglandin Metabolism

Tilo Grosser and Garret A. FitzGerald

Chapter 35:  The Role of Platelets in Blood Coagulation

Peter N. Walsh

Chapter 36:  Blood-Borne Microparticles

José López and Swaminathan Murugappan

SECTION C: VASCULAR BIOLOGY  

William C. Aird

Chapter 37:  Overview of Vascular Biology

William C. Aird

Chapter 38: Development of the Vasculature, Angiogenesis, Lymphangiogenesis

Aernout Luttun and Peter Carmeliet

Chapter 39: Rheology and Vessel Wall Stress

Peter F. Davies, Larry V. McIntire, and Juan M. Jiménez

Chapter 40:  Nitric Oxide

Bradley A. Maron and Thomas Michel

Chapter 41:  Blood Vessel Wall in Health and Disease

Keith R. Brunt, Sonya Hui, Jagdish Butany, and Mansoor Husain

Chapter 42:  Endothelial Cell Function

William C. Aird

Chapter 43:  Role of Endothelium in Hemostasis

Michael J. Krisinger and Edward M. Conway

Chapter 44:  Coagulation-Independent Signaling of the Extrinsic Coagulation Pathway

Wolfram Ruf

Chapter 45:  Heparin and Vascular Proteoglycans

Douglas M. Tollefsen and Lijuan Zhang

Chapter 46: Endothelial Cell-Blood Cell Interactions

Klaus Ley

Chapter 47:  Leukocyte Function and Contribution to Disease

Edith van de Vijver and Taco W. Kuijpers

Chapter 48: Laboratory Markers of Endothelial Cell Activation and Dysfunction

Eduard Shantsila, Gregory Y.H. Lip, and Robert P. Hebbel

PART III:  DISORDERS OF COAGULATION, PLATELETS, AND VESSEL WALL

SECTION A: BLEEDING DISORDERS COAGULATION & FIBRINOLYSIS

Chapter 49: Overview of Inherited Hemorrhagic Disorders

Gilbert C. White, II, Harold R. Roberts, and Victor J. Marder

Chapter 50:  Differential Diagnosis of the Bleeding Patient

Jill M. Johnsen and Barbara A. Konkle 

Chapter 51: Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia

Edward G.D. Tuddenham

Chapter 52: von Willebrand Disease: Diagnosis, Classification, and Treatment

J. Evan Sadler and David Lillicrap

Chapter 53:  Rare Inherited Coagulation Disorders Other than Hemophilia

Pier Mannuccio Manucci, Massimo Franchini, and Flora Peyvandi

Chapter 54: Afibrogenemias and Dysfibrogenemias

Dennis K. Galanakis

Chapter 55: Familial Multiple Coagulation Factor Deficiencies

Bin Zhang and David Ginsburg

Chapter 56:  Clinical Disorders of Fibrinolysis

Daphne Stewart, Charles W. Francis, and Victor J. Marder

Chapter 57: Acquired Disorders of Coagulation: The Immune Coagulopathies

Charles RM Hay

Chapter 58:  Laboratory Markers of Coagulation and Fibrinolysis

Kenneth A. Bauer and Helen A. Ireland

SECTION B: ACQUIRED & INHERITED PLATELET DISORDERS

Chapter 59: Overview of Acquired and Inherited Clinical Platelet Disorders

Joel S. Bennett

Chapter 60: Differential Diagnosis of Thrombocytopenia

Joel S. Bennett and Charles S. Abrams

Chapter 61:  Immune Thrombocytopenic Purpuraand Posttransfusion Purpura

Howard A. Liebman, Douglas B. Cines, and James B. Bussel

Chapter 62: Drug-Induced Thrombocytopenia

Richard H. Aster and James N. George

Chapter 63: Inherited Thrombocytopenias

Paquita Nurden and Alan T. Nurden

Chapter 64: Acquired Nonimmune Thrombocytopenia

Andreas Greinacher and Theodore E. Warkentin

Chapter 65:  Hereditary Disorders of Platelet Function

Joel S. Bennett and A. Koneti Rao

Chapter 66: Acquired Disorders of Platelet Function

A. Koneti Rao and Joel S. Bennett

Chapter 67: Laboratory Markers of Platelet Activation

Paul Harrison and Alan D. Michelson

SECTION C: PRIMARY DISORDERS OF BLOOD VESSELS 

Chapter 68: Overview of Primary Disorders of Blood Vessels

William C. Aird

Chapter 69: Disorders of Connective Tissue and Extracellulara Matrix

Fransiska Malfait and Anne dePaepeChapter 70: Hereditary Hemorrhagic Telangiectasia

Michelle Letarte and Claire L. Shovlin

Chapter 71: Arteriovenous Malformations and Hemangiomas and Cerebral Cavernous Malformations

Douglas A. Marchuk and Mark L. Kahn

Chapter 72: Aneurysms (Large and Small Arteries)

Carlos E. Sanchez, Sangita Kapur, and Neal L. Weintraub

Chapter 73: Intracranial Hemorrhage

Timolaos Rizos and Thorsten Steiner 

Chapter 74: Retinopathy

Jing Chen, , Andreas Stahl, and Lois E.H. Smith

SECTION D: THERAPY OF BLEEDING DISORDERS

Chapter 75: Overview to Therapy of Bleeding Disorders

Gilbert C. White II

Chapter 76: Management of Acute Hemorrhage

Nigel S. Key, Micah J. Mooberry, and Rommer Lu

Chapter 77: Therapy with Antifibrinolytic Agents

Daphne B. Stewart and Victor J. Marder

Chapter 78: Transfusion Medicine

Thomas S. Kickler

Chapter 79: New Approaches for the Therapy of Bleeding Disorders, Including Gene Therapy

Gilbert C. White II and Harold R. Roberts

PART IV: THROMBOTIC DISORDERS

SECTION A: VENOUS THROMBOTIC DISORDERS

Chapter 80.  Overview of Venous Thromboembolism

Sam Schulman, Victor J. Marder, and Gilbert C. White II

Chapter 81: Thrombophilia Genetics

Joseph Emmerich, Martine Aiach, and Pierre-Emmanuel Morange

Chapter 82: Epidemiology and Risk Factors of Venous Thromboembolism

John A. Heit

Chapter 83: Clinical Manifestations and Diagnosis of Venous Thromboembolism

Henri Bounameaux and Arnaud Perrier

Chapter 84: Venous Thrombosis in Unusual Sites

Victor J. Marder, Hylton V. Joffe, and Sam Schulman

Chapter 85: Sequelae of Venous Thromboembolic Disease: Postthrombotic Syndrome and Chronic Thromboembolic Pulmonary Hypertension

Vittorio Pengo and Susan R. Kahn

Chapter 86: Prevention of Venous Thromboembolic Disease

Menno V. Huisman, Ajay Kakkar, Pasha, and Patrick Mismetti

Chapter 87: Treatment of Venous Thromboembolic Disease

Sam Schulman, Jeffrey Ginsberg, and James Douketis

SECTION B: ARTERIAL THROMBOTIC DISORDERS

Chapter 88: Overview of Arterial Thrombotic Disorders

Sam Schulman and Victor J. Marder

Chapter 89: Pathophysiology of Atherosclerosis

Peter Libby, Paul M. Ridker, and Kevin Croce

Chapter 90: Acute Coronary Syndromes: Manifestations and Management

John Paul Vavalle, John H. Alexander, and Matthew T. Roe

Chapter 91: Pathophysiology of Thromboembolic Stroke

Emer R. McGrath and Martin J. O'Donnell

Chapter 92: Prevention of Thromboembolic Stroke in Patients with Atrial Fibrillation, Valvular Heart Disease, Cardiomyopathy

Thomas Kawano and Jonathan L. Halperin

Chapter 93: Acute Stroke: General Management, Anticoagulant, and Thrombolytic Therapy

Gregory J. del Zoppo and Jeffrey L. Saver  

Chapter 94: Medical and Surgical Treatment of Peripheral Arterial Disease

Phillip Joseph, Saurabh Kalra, and Sonia Anand

Chapter 95: Unusual Sites of Arterial Occlusion

Philip A. Kalra, Jon G. Moss, and Peter Wiedemann

Chapter 96: Pathogenesis and Treatment of Biomaterial-Associated Thrombosis

Maud B. Gorbet and Michael V. Sefton

SECTION C:  COMPLEX THROMBOTIC DISORDERS

Chapter 97: Overview of Microvascular and Complex Thrombotic Disorders

Theodore E. Warkentine and Victor J. Marder

Chapter 98: Consumptive Thrombohemorrhagic Disorders

Marcel Levi, Donald I. Feinstein, Robert W. Colman, and Victor J. Marder

Chapter 99: Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome-Microangiopathies

George

Chapter 100: Vasculitides

James R. Stone and John H. Stone

Chapter 101: Antiphospholipid Antibodies and the Antiphospholipid Syndrome

Jacob H. Rand and Lucia R. Wolgast

Chapter 102: Thrombohemorrhagic Complications of Myeloproliferative Disorders

Ayalew Tefferi

Chapter 103:  Thrombotic and Hemorrhagic Complications Associted with Stem Cell Transplantation

Yona Nadir and Benjamin Brenner

SECTION D: THERAPEUTIC AGENTS

Chapter 104: Overview of Therapeutic Agents used in Thrombotic Disorders

Sam Schulman and Victor J. Marder

Chapter 105: Pharmacology and Mode of Action of Heparin and Glycosaminoglycans

Meyer Michael Samama, Jeanine M. Walenga, Evi Kalodiki, and Jawed Fareed

Chapter 106: Vitamin K Antagonists: Biochemistry, Pharmacology and Management

Nirmish Shah, Thomas L. Ortel, and Sam Schulman

Chapter 107: Hemorrhagic Complications of Anticoagulation

Sam Schulman and Mark A. Crowther

Chapter 108: Heparin-Induced Thrombocytopenia

Theodore E. Warkentin and Andreas Greinacher

Chapter 109: Coumarin-Induced Skin Necrosis and Venous Limb Gangrene

Theodore E. Warkentin

Chapter 110: New Antithrombotic Drugs

Jeffrey I. Weitz and Peter L. Gross

Chapter 111: Antiplatelet Therapy

Carlo Patrono

Chapter 112: Thrombolytic Therapy

Victor J. Marder and Daphne B. Stewart

Chapter 113: Anticoagulant and Procoagulant Proteinsin the Animal Kingdom

Angelina Wei Ling Tan, Shiyang Kwong, and R. Manjunatha Kinia

Chapter 114: Mechanical Devices and Embolectomy

Hervé Decousus, Patrick Mismetti, and Nicolas Meneveau

PART V:Hemostatic and Thrombotic Disorders Associated with Systemic Conditions

Chapter 115: Overview of Special Clinical Groups

Victor J. Marder

Chapter 116: VTE during Pregnancy and with Hormonal Contraceptives

Saskia Middeldorp, Mathilde Nijkeuter, and Michiel Coppens

Chapter 117: Gestational Vascular Complications

Benjamin Brenner, Anat Aharon, Jean-Christophe Gris

Chapter 118: Maternal Hemostatic Disorders and Obstetric Hemorrhage

Philippe De Moerloose, Françoise Boehlen, and Jean Christophe Gris

Chapter 119: Developmental Hemostasis

Paul Monagle, Vera Ignatovic, and Leslie Roy Berry

Chapter 120: Bleeding in Neonates and Children

Anthony K. Chan, Elizabeth A. Chalmers, Sam Schulman, and Alan Michelson

Chapter 121: Venous and Arterial Thromboembolism in Children

Paul Monagle, M. Patricia Massicotte, and Anthony K. Chan

Chapter 122: Thrombotic Complications of Sickle Cell Disease

Kenneth I. Ataga and Elliott P. Vichinsky

Chapter 123: Thrombohemorrhagic Complications of Sepsis

Marcel Levi

Chapter 124: Hemorrhagic Fevers: Epidemiology, Pathophysiology, and Clinical Features

Gayani Tillekeratne, Jennifer Cohn, and Hillary Dunlevy

Chapter 125: Cancer-related Thrombosis

Anna Falanga, Agnes Y. Y. Lee, Frederick R. Rickles

Chapter 126: Hemostatic Abnormalities in Liver Disease

Charles S. Eby and Stephen H. Caldwell

Chapter 127: Hemostatic Abnormalities in Renal Disease

Miriam Galbusera, Giuseppe Remuzzi, and Patrizia Ondei

Chapter 128: Multtrauma Derangements in Hemostasis and Thrombosis

Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, and Mitchell Jay Cohen

Chapter 129: Blood Management in the Cardiovascular Surgery Patient

Lawrence Tim Goodnough and L. Henry Edmunds Jr.

Chapter 130: Thrombo-Hemorrhagic Events in the Elderly

Isabelle Mahe and Ludovic Drouet