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This handbook thoroughly covers both therapeutic applications of light and diseases/conditions caused by light exposure. It also discusses the underlying cellular mechanisms and molecular synthesis of photosensitizer dyes used in phototherapy. An introductory section provides the necessary background for newcomers to the field, briefly tracing the history of the field and summarizing fundamental principles. Each subsequent section addresses a major subject of the field, including UV/PVA phototherapy, photodynamic therapy, laser surgery and medicine, and low-level laser/light therapy.
History and Fundamentals
Introduction
Michael R. Hamblin and Ying-Ying Huang
History and Fundamentals of Lasers and Light Sources
Edward Victor Ross
History and Fundamentals of Light Tissue Interactions
Pradeep Kumar Gupta, Mahesh Kumar Swami, and Harishankar Patel
History and Fundamentals of Photodynamic Therapy (PDT): Photophysics and Photochemistry
Tyler G. St. Denis and Michael R. Hamblin
History and Fundamentals of Low-Level Laser/Light Therapy (LLLT)
Asheesh Gupta and Michael R. Hamblin
Diseases Caused by Light
UV Effects on Skin
Kris Nys and Patrizia Agostinis
Photocarcinogenesis Non-Melanoma Skin Cancer
Gary M. Halliday, Scott N. Byrne, J. Guy Lyons, and Diona L. Damian
Auto-Immune Photodermatoses and Photoaggravated Dermatoses
John L.M. Hawk
Therapy of Photodermatoses
PierGiacomo Calzavara-Pinton and Raffaella Sala
Photoaging
Rui Yin and Michael R. Hamblin
UVR-Induced Immunosuppression
Mary Norval and Prue H. Hart
The Porphyrias
Eric Gou and Karl E. Anderson
Photoprotection
Chanisada Wongpraparut and Henry W. Lim
Chemoprevention
Hasan Mukhtar
Reversal of DNA Damage in Skin DNA Repair Liposomes
Peter Wolf
Climate Change and UV Exposure
Mohammad Ilyas
Vitamin D and UV Exposure
Michael F. Holick
Ultraviolet Phototherapy
UVB Phototherapy for Psoriasis
Edidiong Ntuen Kaminska, Piergiacomo Calzavara-Pinton, and Bernhard Ortel
PUVA Therapy
Bernhard Ortel and Herbert Honigsman
Extracorporeal Photopheresis
Fiona Dignan and Julia Scarisbrick
UVC Therapy for Infections
Tianhong Dai and Michael R. Hamblin
Photodynamic Therapy (PDT)
Design and Synthesis of Photosensitizers
Penny Joshi, Courtney Saenz, Joseph R. Missert, and Ravindra K. Pandey
ALA and Derivatives
Asta Juzeniene and Patrycja Mikolajewska
Gentically Encoded Photosensitizers
Cristina Flors and Santi Nonell
Light Delivery and Dosimetry
Henricus J.C.M. Sterenborg, Robert L.P. van Veen, Jan-Bonne Aans, Arjen Amelink, and Dominic J. Robinson
Multi-Modality Dosimetry
Jarod Finlay
Cell Signaling and Cell Death Pathways
Abhishek D. Garg and Patrizia Agostinis
Vascular and Cellular Targeted PDT
Shannon M. Gallagher-Colombo and Theresa M. Busch
PDT for Increased Delivery of Anti-Cancer Drugs
Elodie Debefve, Yabo Wang, Thorsten Krueger, and Hubert van den Bergh
Targeted Photosensitizer Conjugates
Marlène Pernot, Céline Frochot, Régis Vanderesse, and Muriel Barberi-Heyob
Mechanism-Based Combination Therapies
Lei Zak Zheng, R. Bryan Sears, Iqbal Massodi, Stanley Kimani, and Tayyaba Hasan
Nanoparticles and Nanotechology
Girgis Obaid and David A. Russell
Drug Delivery Systems for Photodynamic Therapy
Ryan F. Donnelly
PDT for Infections
Tim Maisch
PDT and the Immune System
Fatma Vatansever and Michael R. Hamblin
From Bench to Bedside—the Hexvix Story
Georges. Wagnières, Patcrick. Jichlinski, Norbert. Lange, P. Kucera and Hubert. van den Bergh
From Bench to Bedside—the PCI Story
Kristian Berg, Anette Weyergang, Anders Høgset, and Pål K. Selbo
From Bench to Bedside—the TOOKAD Story
Avigdor Scherz and Yoram Salomon
PDT in Ophthalmology
Patrycja Nowak-Sliwinska, Andrea Weiss, Michel Sickenberg, and Hubert van den Bergh
PDT in Dermatology
Alexis Sidoroff
PDT in Gastroenterology
Drew Schembre
Photodynamic Applications in Brain Tumors
Sam Eljamel
PDT for Malignant Pleural Disease
Charles B. Simone, Melissa Culligan, Joseph S. Friedberg, and Keith A. Cengel
Clinical PDT in China
Yih-Chih Hsu and Zheng Huang
Photodynamic therapy and fluorescent diagnostics in Russian Federation
Elena G. Vakulovskaya
Low-Level Light Therapy (LLLT)
Chromophores (photoacceptors) for LLLT
Tiina I. Karu
LLLT Signaling Pathways
Da Xing and Shengnan Wu
Irradiation Parameters, Dose Response, and Devices
James D Carroll
LLLT: Clearly a New Paradigm in the Management of Cancer Therapy-Induced Mucositis
Rene Bensadoun
LLLT for Wound Healing
Lilach Gavish
LLLT in the Treatment of Pain
Roberta Chow
LLLT in Arthritis and Tendinopathies
Jan Magnus Bjordal
LLLT and Light-Emitting Diode Therapy (LEDT) on Muscle Tissue: Performance, Fatigue, and Repair
Cleber Ferraresi and Nivaldo Parizotto
LLLT for Stroke and Brain Disease
Takahiro Ando and Michael R Hamblin
LLLT for Nerve and Spinal Cord Regeneration
Nivaldo Parizotto
LLLT in Dentistry
Daiane Thais Meneguzzo and Leila Soares Ferreira
LLLT and Stem Cells
Heidi Abrahamse
LLLT for Cosmetics and Dermatology
Pinar Avci, Theodore Nyame, and Michael R. Hamblin
Surgical Laser Therapy
Lasers in Dermatology (Therapeutics)
Rui Yin, Garuna Kositratna, and Rox R Anderson
Therapeutic Uses of Lasers in Eye Care
Charles Wormington
Lasers in Dentistry
Kirpa Johar
Lasers in Urology
James Lingeman
Lasers in Otolaryngology
James A. Burns and Anca M. Barbu
Laser Targeting to Nanoparticles for Theranostic Applications
James Ramos, Huang-Chiao Huang and Kaushal Rege
Laser Immunotherapy
Tomas Hode, Xiaosong Li, Mark Naylor, Lars Hode, Peter Jenkins, Gabriela Ferrel, Robert E. Nordquist, Orn Adalsteinsson, John Lunn, Michael R. Hamblin, Luciano Alleruzzo, and Wei R. Chen
Tissue Repair by Photochemical Crosslinking
Irene Kochevar and Robert Redmond
Other Phototherapy and Future Outlook
Optical-Guided Interventions
Brian C. Wilson and Robert Weersink
Phototherapy for Newborn Jaundice
Michael Andrew Choma
Biological Evidence of the Efficacy of Light Therapy in Psychiatric Disorders
Anne-Marie Gagné and Marc Hebert
Future Developments in Photomedicine
Thierry J. Patrice
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