Table of Contents

History and Fundamentals
Introduction
Michael R. Hamblin and Ying-Ying Huang

History and Fundamentals of Lasers and Light Sources
Edward Victor Ross

History and Fundamentals of Light Tissue Interactions
Pradeep Kumar Gupta, Mahesh Kumar Swami, and Harishankar Patel

History and Fundamentals of Photodynamic Therapy (PDT): Photophysics and Photochemistry
Tyler G. St. Denis and Michael R. Hamblin

History and Fundamentals of Low-Level Laser/Light Therapy (LLLT)
Asheesh Gupta and Michael R. Hamblin

Diseases Caused by Light
UV Effects on Skin
Kris Nys and Patrizia Agostinis

Photocarcinogenesis Non-Melanoma Skin Cancer
Gary M. Halliday, Scott N. Byrne, J. Guy Lyons, and Diona L. Damian

Auto-Immune Photodermatoses and Photoaggravated Dermatoses
John L.M. Hawk

Therapy of Photodermatoses
PierGiacomo Calzavara-Pinton and Raffaella Sala

Photoaging
Rui Yin and Michael R. Hamblin

UVR-Induced Immunosuppression
Mary Norval and Prue H. Hart

The Porphyrias
Eric Gou and Karl E. Anderson

Photoprotection
Chanisada Wongpraparut and Henry W. Lim

Chemoprevention
Hasan Mukhtar

Reversal of DNA Damage in Skin DNA Repair Liposomes
Peter Wolf

Climate Change and UV Exposure
Mohammad Ilyas

Vitamin D and UV Exposure
Michael F. Holick

Ultraviolet Phototherapy
UVB Phototherapy for Psoriasis
Edidiong Ntuen Kaminska, Piergiacomo Calzavara-Pinton, and Bernhard Ortel

PUVA Therapy
Bernhard Ortel and Herbert Honigsman

Extracorporeal Photopheresis
Fiona Dignan and Julia Scarisbrick

UVC Therapy for Infections
Tianhong Dai and Michael R. Hamblin

Photodynamic Therapy (PDT)
Design and Synthesis of Photosensitizers
Penny Joshi, Courtney Saenz, Joseph R. Missert, and Ravindra K. Pandey

ALA and Derivatives
Asta Juzeniene and Patrycja Mikolajewska

Gentically Encoded Photosensitizers
Cristina Flors and Santi Nonell

Light Delivery and Dosimetry
Henricus J.C.M. Sterenborg, Robert L.P. van Veen, Jan-Bonne Aans, Arjen Amelink, and Dominic J. Robinson

Multi-Modality Dosimetry
Jarod Finlay

Cell Signaling and Cell Death Pathways
Abhishek D. Garg and Patrizia Agostinis

Vascular and Cellular Targeted PDT
Shannon M. Gallagher-Colombo and Theresa M. Busch

PDT for Increased Delivery of Anti-Cancer Drugs
Elodie Debefve, Yabo Wang, Thorsten Krueger, and Hubert van den Bergh

Targeted Photosensitizer Conjugates
Marlène Pernot, Céline Frochot, Régis Vanderesse, and Muriel Barberi-Heyob

Mechanism-Based Combination Therapies
Lei Zak Zheng, R. Bryan Sears, Iqbal Massodi, Stanley Kimani, and Tayyaba Hasan

Nanoparticles and Nanotechology
Girgis Obaid and David A. Russell

Drug Delivery Systems for Photodynamic Therapy
Ryan F. Donnelly

PDT for Infections
Tim Maisch

PDT and the Immune System
Fatma Vatansever and Michael R. Hamblin

From Bench to Bedside—the Hexvix Story
Georges. Wagnières, Patcrick. Jichlinski, Norbert. Lange, P. Kucera and Hubert. van den Bergh

From Bench to Bedside—the PCI Story
Kristian Berg, Anette Weyergang, Anders Høgset, and Pål K. Selbo

From Bench to Bedside—the TOOKAD Story
Avigdor Scherz and Yoram Salomon

PDT in Ophthalmology
Patrycja Nowak-Sliwinska, Andrea Weiss, Michel Sickenberg, and Hubert van den Bergh

PDT in Dermatology
Alexis Sidoroff

PDT in Gastroenterology
Drew Schembre

Photodynamic Applications in Brain Tumors
Sam Eljamel

PDT for Malignant Pleural Disease
Charles B. Simone, Melissa Culligan, Joseph S. Friedberg, and Keith A. Cengel

Clinical PDT in China
Yih-Chih Hsu and Zheng Huang

Photodynamic therapy and fluorescent diagnostics in Russian Federation
Elena G. Vakulovskaya

Low-Level Light Therapy (LLLT)
Chromophores (photoacceptors) for LLLT
Tiina I. Karu

LLLT Signaling Pathways
Da Xing and Shengnan Wu

Irradiation Parameters, Dose Response, and Devices
James D Carroll

LLLT: Clearly a New Paradigm in the Management of Cancer Therapy-Induced Mucositis
Rene Bensadoun

LLLT for Wound Healing
Lilach Gavish

LLLT in the Treatment of Pain
Roberta Chow

LLLT in Arthritis and Tendinopathies
Jan Magnus Bjordal

LLLT and Light-Emitting Diode Therapy (LEDT) on Muscle Tissue: Performance, Fatigue, and Repair
Cleber Ferraresi and Nivaldo Parizotto

LLLT for Stroke and Brain Disease
Takahiro Ando and Michael R Hamblin

LLLT for Nerve and Spinal Cord Regeneration
Nivaldo Parizotto

LLLT in Dentistry
Daiane Thais Meneguzzo and Leila Soares Ferreira

LLLT and Stem Cells
Heidi Abrahamse

LLLT for Cosmetics and Dermatology
Pinar Avci, Theodore Nyame, and Michael R. Hamblin

Surgical Laser Therapy
Lasers in Dermatology (Therapeutics)
Rui Yin, Garuna Kositratna, and Rox R Anderson

Therapeutic Uses of Lasers in Eye Care
Charles Wormington

Lasers in Dentistry
Kirpa Johar

Lasers in Urology
James Lingeman

Lasers in Otolaryngology
James A. Burns and Anca M. Barbu

Laser Targeting to Nanoparticles for Theranostic Applications
James Ramos, Huang-Chiao Huang and Kaushal Rege

Laser Immunotherapy
Tomas Hode, Xiaosong Li, Mark Naylor, Lars Hode, Peter Jenkins, Gabriela Ferrel, Robert E. Nordquist, Orn Adalsteinsson, John Lunn, Michael R. Hamblin, Luciano Alleruzzo, and Wei R. Chen

Tissue Repair by Photochemical Crosslinking
Irene Kochevar and Robert Redmond

Other Phototherapy and Future Outlook
Optical-Guided Interventions
Brian C. Wilson and Robert Weersink

Phototherapy for Newborn Jaundice
Michael Andrew Choma

Biological Evidence of the Efficacy of Light Therapy in Psychiatric Disorders
Anne-Marie Gagné and Marc Hebert

Future Developments in Photomedicine
Thierry J. Patrice