1 Approach to Medicine, the Patient, and the Medical Profession
2 Bioethics in the Practice of Medicine
3 Palliative Care
4 Disparities in Health and Health Care
5 Global Health
6 History and Physical Examination
7 Approach to the Patient with Abnormal Vital Signs
8 Statistical Interpretation of Data for Clinical Decisions
9 Measuring Health and Health Care
10 Quality, Safety, and Value
11 Comprehensive Chronic Disease Management
11 Population Health
12 The Periodic Health Examination
13 Diet and Nutrition
14 Physical Activity
15 Immunization
16 Principles of Occupational and Environmental Medicine
17 Effects of Climate Change  on Health
18 Radiation Injury
19 Bioterrorism
20 Chronic Poisoning: Trace Metals and Others
21 Adolescent Medicine
22 Epidemiology of Aging
23 Geriatric Assessment
24 Common Clinical Sequelae of Aging
25 Principles of Drug Therapy
26 Pain
27 Delirium in the Older Patient
27 Biology of Addiction
28 Immunomodulatory Drugs
29 Biologic Agents and Signaling Inhibitors
30 Complementary, Alternative, and Integrative Medicine
31 Principles of Genetics
32 Clinical Genomics – Genome Structure and Variation
33 Applications of Molecular Technologies to Clinical Medicine
34 Regenerative Medicine, Cell, and Gene Therapies
35 Innate and Adaptive Immunity
36 Tissue Injury and Repair
37 Complement System in Disease
38 Transplantation Immunology
39 Approach to the Patient with Possible Cardiovascular Disease
40 Epidemiology of Cardiovascular Disease
41 The Adaptive Immunse System
41 Cardiac and Circulatory Function
42 Mechanisms of Inflammation and Tissue Repair
42 Electrocardiography
43 Echocardiography
44 Noninvasive Cardiac Imaging
45 Heart Failure: Epidemiology, Pathobiology, and Diagnosis
46 Heart Failure: Treatment, Prevention, and Prognosis
47 Diseases of the Myocardium and Endocardium
48 Principles of Electrophysiology
49 Approach to the Patient with Suspected Arrhythmia
50 Catheterization and Angiography
50 Cardiac Arrest and Life-Threatening Arrhythmias
51 Bradycardias
52 Supraventricular Tachycardias
53 Ventricular Arrhythmias
54 Electrophysiologic Procedures and Surgery
55 Congenital Heart Disease in Adults
56 Chronic Ischemic Heart Disease
57 Acute Coronary Syndrome: Unstable Angina and Non-ST Elevation Myocardial Infarction
58 ST Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction
59 Interventional and Surgical Treatment of Coronary Artery Disease
60 Valvular Heart Disease
61 Infective Endocarditis
62 Pericardial Diseases
63 Diseases of the Aorta
64 Arterial Hypertension
65 Atherosclerotic Peripheral Arterial Disease
66 Other Peripheral Arterial Diseases
67 Thrombotic Disorders: Hypercoagulable States
68 Venous Thrombosis and Embolism
69 Pulmonary Hypertension
70 Antithrombotic and Antiplatelet Therapy
71 Approach to the Patient with Respiratory Disease
72 Imaging in Pulmonary Disease
73 Respiratory Testing and Function
74 Disorders of Ventilatory Control
75 Asthma
76 Chronic Obstructive Pulmonary Disease
77 Cystic Fibrosis
78 Bronchiectasis, Atelectasis, Cysts, and Localized Lung Disorders
79 Alveolar Filling Disorders
80 Interstitial Lung Disease
81 Occupational Lung Disease
82 Physical and Chemical Injuries of the Lung
83 Sarcoidosis
84 Acute Bronchitis and Tracheitis
85 Overview of Pneumonia
86 Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum
87 Interventional and Surgical Approaches to Lung Disease
88 Approach to the Patient in a Critical Care Setting
89 Respiratory Monitoring in Critical Care
90 Acute Respiratory Failure
91 Mechanical Ventilation
92 Approach to the Patient with Shock
93 Cardiogenic Shock
94 Shock Syndromes Related to Sepsis
95 Disorders Due to Heat and Cold
96 Acute Poisoning
97 Medical Aspects of Trauma and Burns
98 Envenomation, Bites, and Stings
99 Rhabdomyolysis
100 Approach to the Patient with Renal Disease
101 Structure and Function of the Kidneys
102 Disorders of Sodium and Water Homeostasis
103 Potassium Disorders
104 Acid-Base Disorders
105 Disorders of Magnesium and Phosphorus
106 Acute Kidney Injury
107 Glomerular Disorders and Nephrotic Syndromes
108 Tubulointerstitial Diseases
109 Diabetes and the Kidney
110 Vascular Disorders of the Kidney
111 Nephrolithiasis
112 Cystic Kidney Diseases
113 Hereditary and Developmental Abnormalities of the Urinary Tract
114 Benign Prostatic Hyperplasia and Prostatitis
115 Urinary Incontinence
116 Chronic Kidney Disease
117 Treatment of Irreversible Renal Failure
118 Approach to the Patient with Gastrointestinal Disease
119 Diagnostic Imaging Procedures in Gastroenterology
120 Gastrointestinal Endoscopy
121 Gastrointestinal Hemorrhage
122 Disorders of Gastrointestinal Motility
123 Functional Gastrointestinal Disorders: Irritable Bowel and Upper GI Syndromes
124 Diseases of the Esophagus
125 Acid Peptic Disease
126 Approach to the Patient with Diarrhea and Malabsorption
127 Inflammatory Bowel Disease
128 Anatomic and Inflammatory Diseases of the Intestines and Peritoneum
129 Vascular Gastrointestinal Diseases
130 Pancreatitis
131 Diseases of the Rectum and Anus
132 Approach to the Patient with Liver Disease
133 Approach to the Patient with Jaundice or Abnormal Liver Tests
134 Acute Viral Hepatitis
135 Chronic Viral and Autoimmune Hepatitis
136 Toxin- and Drug-Induced Liver Disease
137 Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases
138 Alcoholic and Nonalcoholic Steatohepatitis
139 Cirrhosis and Its Sequelae
140 Hepatic Failure and Liver Transplantation
141 Diseases of the Gallbladder and Bile Ducts
142 Hematopoiesis and Hematopoietic Growth Factors
143 The Peripheral Blood Smear
144 Approach to the Anemias
145 Microcytic and Hypochromic Anemias
146 Autoimmune and Intravascular Hemolytic Anemias
147 Hemolytic Anemias: Red Cell Membrane and Metabolic Defects
148 The Thalassemias
149 Sickle Cell Disease and Other Hemoglobinopathies
150 Megaloblastic Anemias
151 Aplastic Anemia and Related Bone Marrow Failure States
152 Polycythemia Vera, Essential Thrombocythemia, and Primary Myelobfibrosis
153 Leukocytosis and Leukopenia
154 Approach to the Patient with Lymphadenopathy and Splenomegaly
155 Histiocytoses
156 Eosinophilic Syndromes
157 Approach to the Patient with Bleeding and Thrombosis
158 Thrombocytopenia
159 Von Willebrand Disease and Abnormalities of Platelet and Vascular Function
160 Coagulation Factor Deficiencies
161 Disseminated Intravascular Coagulation, Liver Failure, and Vitamin K Deficiency
162 Transfusion Medicine
163 Hematopoietic Stem Cell Transplantation
164 Approach to the Patient with Cancer
165 Epidemiology of Cancer
166 Cancer Biology and Genetics
167 Myelodysplastic Syndromes
168 The Acute Leukemias
169 The Chronic Lymphocytic Leukemia
170 Chronic Myeloid Leukemias
171 Non-Hodgkin Lymphomas
172 Hodgkin Lymphoma
173 Plasma Cell Disorders
174 Amyloidosis
175 Tumors of the Central Nervous System
176 Head and Neck Cancer
177 Lung Cancer and Other Pulmonary Neoplasms
178 Neoplasms of the Esophagus and Stomach
179 Neoplasms of the Small and Large Intestine
180 Pancreatic Cancer
181 Liver and Biliary Tract Tumors
182 Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis
183 Breast Cancer and Benign Breast Disorders
184 Gynecologic Cancers
185 Testicular Cancer
186 Prostate Cancer
187 Bone Tumors, Sarcomas, and Other Soft Tissue Neoplasms
188 Melanoma and Nonmelanoma Skin Cancers
189 Approach to Inborn Errors of Metabolism
190 Disorders of Lipid Metabolism
191 Glycogen Storage Diseases
192 Lysosomal Storage Diseases
193 Homocystinuria and Hyperhomocysteinemia
194 The Porphyrias
195 Wilson Disease
196 Iron Overload (Hemochromatosis)
197 Protein-Energy Malnutrition
198 Malnutrition: Assessment and Support
199 Vitamins, Trace Minerals, and Other Micronutrients
200 Eating Disorders
200 Nutrition’s Interface with Health and Disease
201 Obesity
202 Approach to the Patient with Endocrine Disease
203 Principles of Endocrinology
204 Neuroendocrinology and the Neuroendocrine System
205 Anterior Pituitary
206 Posterior Pituitary
207 Thyroid
208 Adrenal Cortex
209 Adrenal Medulla, Catecholamines, and Pheochromocytoma
210 Diabetes Mellitus
211 Hypoglycemia and Pancreatic Islet Cell Disorders
212 Polyglandular Disorders
213 Neuroendocrine Tumors
214 Sexual Development, Identity, and Gender Medicine
215 Transgender Medicine
216 The Testis and Male Hypogonadism, Infertility, and Sexual Function
217 Ovaries and Pubertal Development
218 Reproductive Endocrinology and Infertility
219 Approach to Women’s Health
220 Contraception
221 Common Medical Problems in Pregnancy
222 Menopause
223 Intimate Partner Violence
224 Approach to the Patient with Metabolic Bone Disease
225 Osteoporosis
226 Osteomalacia and Rickets
227 Parathyroid Glands, Hypercalcemia, and Hypocalcemia
228 Paget Disease of Bone
229 Osteonecrosis, Osteosclerosis/Hyperostosis, and Other Bone Disorders
230 Approach to the Patient with Allergic or Immunologic Disease
231 Primary Immunodeficiency Diseases
232 Urticaria and Angioedema
233 Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy
234 Drug Allergy
235 Mastocytosis
236 Approach to the Patient with Rheumatic Disease
237 Laboratory Testing in the Rheumatic Diseases
238 Imaging Studies in the Rheumatic Diseases
239 Inherited Diseases of Connective Tissue
240 The Systemic Autoinflammatory Diseases
241 Osteoarthritis
242 Bursitis, Tendinitis, Periarticular Disorders, and Sports Medicine
243 Rheumatoid Arthritis
244 The Spondyloarthropathies
245 Systemic Lupus Erythematosus
246 Systemic Sclerosis (Scleroderma)
247 Sjögren Syndrome
248 Inflammatory Myopathies
249 The Systemic Vasculitides
250 Giant Cell Arteritis and Polymyalgia Rheumatica
251 Infections of Bursae, Joints, and Bones
252 Crystal Deposition Diseases
253 Fibromyalgia, Chronic Fatigue Syndrome, and Myofascial Pain
254 Systemic Diseases in Which Arthritis Is a Feature
255 Surgical Treatment of Joint Diseases
256 Introduction to Microbial Disease: Pathophysiology and Diagnostics
257 The Human Microbiome
258 Principles of Anti-Infective Therapy
259 Approach to Fever or Suspected Infection in the Normal Host
260 Approach to Fever and Suspected Infection in the Compromised Host
261 Prevention and Control of Health Care–Associated Infections
262 Approach to the Patient with Suspected Enteric Infection
263 Approach to the Patient with Urinary Tract Infection
264 Approach to the Patient with a Sexually Transmitted Infection
265 Approach to the Patient before and after Travel
266 Antibacterial Chemotherapy
267 Staphylococcal Infections
268 Streptococcus Pneumoniae Infections
269 Nonpneumococcal Streptococcal Infections and Rheumatic Fever
270 Enterococcal Infections
271 Clostridial and Clostridioides Infections
272 Gram Positive Rod Infections
273 Diseases Caused by Non–Spore-Forming Anaerobic Bacteria
274 Erysipelothrix Infections
274 Neisseria Meningitidis Infections
274 Anthrax
274 Listeriosis
275 Neisseria Gonorrhoeae Infections
276 Chancroid and Cutaneous Ulcers
277 Haemophilus and Moraxella Infections
278 Cholera and Other Vibrio Infections
279 Campylobacter Infections
280 Escherichia Coli Enteric Infections
281 Other Enterobacteriaceae including Multidrug Resistant Strains
282 Pseudomonas and Related Gram-Negative Bacillary Infections
283 Acinetobacter and Stenotrophomonas Infections
284 Salmonella Infections (including enteric fever)
285 Shigellosis
286 Brucellosis
287 Tularemia and Other Francisella Infections
288 Plague and Other Yersinia Infections
289 Whooping Cough and Other Bordetella Infections
290 Legionella Infections
291 Bartonella Infections
291 Granuloma Inguinale (Donovanosis)
292 Granuloma Inguinale (Donovanosis)
293 Mycoplasma Infections
294 Diseases Caused by Chlamydiae
295 Syphilis and Nonsyphilitic Treponematoses
296 Lyme Disease
297 Relapsing Fever and Other Borrelia Infections
298 Leptospirosis
298 Nonsyphilitic Treponematoses
299 Tuberculosis
300 The Nontuberculous Mycobacteria
301 Leprosy (Hansen Disease)
302 Rickettsial Infections
303 Zoonoses
304 Actinomycosis
305 Whipple Disease
306 Nocardiosis
307 Systemic Antifungal Agents
308 Endemic Fungi
309 Cryptococcosis
310 Candidiasis
311 Aspergillosis
312 Mucormycosis
313 Pneumocystis Pneumonia
314 Mycetoma and Dematiaceous Fungal Infections
315 Antiparasitic Therapy
316 Malaria
317 African Sleeping Sickness
318 Chagas Disease
319 Leishmaniasis
320 Toxoplasmosis
321 Cryptosporidiosis
322 Giardiasis
323 Amebiasis
324 Babesiosis and Other Protozoan Diseases
325 Cestodes
326 Trematode Infections
327 Nematode Infections
328 Antiviral Therapy (Non-HIV)
329 The Common Cold
330 Respiratory Syncytial Virus
331 Parainfluenza Viral Disease
332 Influenza
333 Adenovirus Diseases
334 Pre-2019 Coronaviruses
335 Covid-19 Virology and Pathobiology
336 Covid-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention
337 COVID-19 Treatment, Vaccination, and Prognosis
338 Measles
339 Rubella (German Measles)
340 Mumps
341 Polyomaviruses
342 Parvovirus
343 Smallpox, Monkeypox, and Other Poxvirus Infections
344 Papillomavirus
345 Herpes Simplex Virus Infections
346 Varicella-Zoster Virus (Chickenpox, Shingles)
347 Cytomegalovirus
348 Epstein-Barr Virus Infection
349 Enteroviruses
350 Rotaviruses, Noroviruses, and Other Gastrointestinal Viruses
351 Viral Hemorrhagic Fevers
351 Arboviruses Affecting the Central Nervous System
352 Arboviruses Causing Fever, Rash, and Neurologic Syndromes
353 EPIDEMIOLOGY AND DIAGNOSIS OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION AND ACQUIRED IMMUNODEFICIENCY SYNDROME
354 Pathobiology of HIV Infection
355 Acute Clinical Manifestation and Diagnosis of HIV
356 Prevention of HIV Infection
357 Antiretroviral Therapy of HIV/AIDS
358 Microbial Complications of HIV/AIDS
359 Systemic Manifestations of HIV/AIDS
359 Immune Reconstitution Inflammatory Syndrome in HIV/AIDS
360 Retroviruses Other Than HIV
361 Delirium and Changes in Mental Status
362 Psychiatric Disorders in Medical Practice
363 Nicotine and Tobacco Use
364 Alcohol Use Disorders
365 Drug Abuse Disorders
366 Approach to the Patient with Neurologic Disease
367 Headaches and Other Head Pain
368 Traumatic Brain Injury and Spinal Cord Injury
369 Mechanical and Other Lesions of the Spine, Nerve Roots, and Spinal Cord
370 Regional Cerebral Dysfunction: Higher Mental Functions
371 Alzheimer and Other Dementias
372 The Epilepsies
373 Coma, Vegetative State, and Brain Death
374 Sleep Disorders
375 Approach to Cerebrovascular Diseases
376 Ischemic Cerebrovascular Disease
377 Hemorrhagic Cerebrovascular Disease
378 Prion Diseases
378 Parkinsonism
379 Other Movement Disorders
380 Multiple Sclerosis and Demyelinating Conditions
381 Meningitis: Bacterial, Viral, and Other
382 Brain Abscess and Parameningeal Infections
383 Encephalitis
384 Nutritional and Alcohol-Related Neurologic Disorders
385 Congenital, Developmental, and Neurocutaneous Disorders
386 Autonomic Disorders
387 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
388 Peripheral Neuropathies
389 Muscle Diseases
390 Disorders of Neuromuscular Transmission
391 Diseases of the Visual System
392 Neuro-Ophthalmology
393 Diseases of the Mouth and Salivary Glands
394 Approach to the Patient with Nose, Sinus, and Ear Disorders
395 Smell and Taste
396 Hearing and Equilibrium
397 Throat Disorders
398 Principles of Medical Consultation
399 Preoperative Evaluation
400 Overview of Anesthesia
401 Postoperative Care and Complications
402 Medical Consultation in Psychiatry
403 Approach to Skin Diseases
404 Principles of Therapy of Skin Diseases
405 Eczema, Photodermatoses, Papulosquamous (including Fungal) Diseases, and Figurate Erythemas
406 Macular, Papular, Vesiculobullous, and Pustular Diseases
407 Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases
408 Infections, Pigmentation Disorders, Regional Dermatology, and Distinctive Lesions in Black Skin
409 Diseases of Hair and Nails
 Reference Intervals and Laboratory Values