Titolo: Glioma Imaging

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Oncologia e Radioterapia

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Glioma Imaging

Physiologic, Metabolic, and Molecular Approaches

Editore

Springer

Anno

2020

Pagine

286

ISBN

9783030273613

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

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This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.

The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:

current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits

Indications and Limitations of Conventional Imaging – Current Clinical Practice in the Context of Standard Therapy

Pages 1-15

Huang, Raymond Y. (et al.)
Surrogates for Disease Status: Contrast Enhancement Including Limitations of Pseudoprogression and Pseudoresponse

Pages 17-29

Hattingen, Elke
The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma

Pages 31-48

Lupo, Janine M. (et al.)
Contrast-Enhanced T1-Weighted Digital Subtraction for Increased Lesion Conspicuity and Quantifying Treatment Response in Malignant Gliomas

Pages 49-60

Ellingson, Benjamin M.
Advanced Physiologic Imaging: Perfusion – Theory and Applications

Pages 61-91

Kickingereder, Philipp (et al.)

Advanced Physiologic Imaging: Diffusion – Theory and Applications

Pages 93-108

LaViolette, Peter S.
Parametric Response Map (PRM) Analysis Improves Response Assessment in Gliomas

Pages 109-126

Cardenas, Michael (et al.)
Review of WHO 2016 Changes to Classification of Gliomas; Incorporation of Molecular Markers

Pages 127-138

Johnson, Derek R. (et al.)
Imaging Markers of Lower-Grade Diffuse Glioma

Pages 139-159

Morrison, Melanie A. (et al.)
CEST, pH, and Glucose Imaging as Markers for Hypoxia and Malignant Transformation

Pages 161-172

Paech, Daniel (et al.)
MRS for D-2HG Detection in IDH-Mutant Glioma

Pages 173-189

Andronesi, Ovidiu C. (et al.)
C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors

Pages 191-209

Viswanath, Pavithra (et al.)
FET and FDOPA PET Imaging in Glioma

Pages 211-221

Galldiks, Norbert (et al.)
Imaging Genomics

Pages 223-239

Kersch, Cymon N. (et al.)
Radiomics and Machine Learning

Pages 241-249

Ferris, Julie (et al.)
Immunotherapy and Gliomas

Pages 251-265

Wang, Elise (et al.)
The Path Forward: The Standardized Brain Tumor Imaging Protocol (BTIP) for Multicenter Trials

Pages 267-282

Ellingson, Benjamin M. (et al.)