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Pre-analytics, Current Testing Technologies, and Limitations of Testing
Pages 3-23
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care.
This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.
Pre-analytics, Current Testing Technologies, and Limitations of Testing
Pages 3-23
Next-Generation Sequencing
Pages 25-40
Cell-Free DNA Testing
Pages 41-54
Role of Bioinformatics in Molecular Medicine
Pages 55-68
Interpreting Genomic Reports
Pages 69-80
Lung Carcinoma
Pages 83-101
GI Including GIST
Pages 103-122
Breast
Pages 123-131
Genitourinary Tumors
Pages 133-147
Gynecologic Malignancies
Pages 149-158
Sarcomas
Pages 159-182
Salivary Gland Carcinomas
Pages 183-195
Sinonasal Carcinomas
Pages 197-203
Acute Myeloid Neoplasms
Pages 207-233
Chronic Myeloid Neoplasms
Pages 235-251
Lymphomas
Pages 253-315
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