Table of Contents

Part I Update on Prostate Tumor Pathology
1 Anatomy of the Prostate Revisited: Implications for Prostate
Biopsy and Zonal Origins of Prostate Cancer 3
Samson W. Fine and Rohit Mehra
2 Contemporary Gleason Grading System 13
Kiril Trpkov
3 Contemporary Prostate Cancer Staging 33
Christopher G. Przybycin, Sara M. Falzarano and Cristina
Magi-Galluzzi
4 Prostate Cancer Reporting on Biopsy and Radical
Prostatectomy Specimens 45
Samson W. Fine
5 Unusual Epithelial and Nonepithelial Neoplasms
of the Prostate 65
Adeboye O. Osunkoya and Cristina Magi-Galluzzi
6 Management Implications Associated with Unusual
Morphologic Entities of the Prostate 79
Viraj A. Master, Jonathan Huang, Cristina Magi-Galluzzi
and Adeboye O. Osunkoya
7 Nomograms for Prostate Cancer Decision Making 93
Cesar E. Ercole, Michael W. Kattan and Andrew J. Stephenson
8 Genetic Determinants of Familial and Hereditary Prostate
Cancer 113
Jesse K. McKenney, Christopher G. Przybycin and Cristina
Magi-Galluzzi
9 New Molecular Markers of Diagnosis and Prognosis in
Prostate Cancer 123
Rajal B. Shah and Ritu Bhalla

10 Intraoperative Consultation for Prostate Tumors:
Challenges and Implications for Treatment 145
Hiroshi Miyamoto and Steven S. Shen
11 Genomics and Epigenomics of Prostate Cancer 149
Juan Miguel Mosquera, Pei-Chun Lin and Mark A.
Rubin
Part II Update on Bladder Tumor Pathology
12 Anatomy of the Urinary Bladder Revisited: Implications
for Diagnosis and Staging of Bladder Cancer 173
Victor E. Reuter
13 Classification and Histologic Grading of Urothelial
Neoplasms by the WHO 2004 (ISUP 1998) Criteria 189
Jesse K. McKenney
14 Reporting of Bladder Cancer in Transurethral Resection
of Bladder Tumor and Cystectomy Specimens 201
Jesse K. McKenney
15 Urothelial Carcinoma Variants: Morphology
and Association with Outcomes 205
Gladell P. Paner and Donna E. Hansel
16 Independent Predictors of Clinical Outcomes and Prediction
Models on Bladder and Upper Urinary Tract Cancer 223
Maria Carmen Mir, Andrew J. Stephenson and Michael W.
Kattan
17 Familial Urothelial Carcinomas 231
Christopher G. Przybycin and Jesse K. McKenney
18 New Molecular Markers with Diagnostic and Prognostic
Values in Bladder Cancer 235
Hikmat A. Al-Ahmadie and Gopa Iyer
19 Intraoperative Consultation for Bladder Tumors:
Challenges and Implications for Treatment 247
Hiroshi Miyamoto and Steven S. Shen
20 Genetic and Epigenetic Alterations in Urothelial Carcinoma 253
Hikmat A. Al-Ahmadie and Gopa Iyer
21 Urine Cytology 261
Jordan P. Reynolds

Part III Update on Renal Tumor Pathology
22 Anatomy of the Kidney Revisited: Implications for Diagnosis
and Staging of Renal Cell Carcinoma 271
Stephen M. Bonsib
23 Classification of Adult Renal Tumors and Grading
of Renal Cell Carcinoma 285
William R. Sukov and John C. Cheville
24 Tumor Staging for Renal Pathology 299
Stephen M. Bonsib
25 Surgical Pathology Reporting of Renal Cell Carcinomas 315
Christopher G. Przybycin, Angela Wu and Lakshmi P.
Kunju
26 Newly Described Entities in Renal Tumor Pathology 321
Angela Wu, Christopher G. Przybycin and Lakshmi P.
Kunju
27 Clinical and Management Implications Associated with
Histologic Subtypes of Renal Cell Carcinomas 341
Maria Carmen Mir, Brian I. Rini and Steven C.
Campbell
28 Independent Predictors of Clinical Outcomes and Prediction
Models for Renal Tumor Pathology 355
Nils Kroeger, Daniel Y. C. Heng and Michael W. Kattan
29 Pathology of Inherited Forms of Renal Carcinoma 373
Maria J. Merino
30 The Utility of Immunohistochemistry in the Differential
Diagnosis of Renal Cell Carcinomas 383
Ming Zhou and Fang-Ming Deng
31 Intraoperative Consultation for Renal Masses: Challenges
and Implications for Treatment 401
Hiroshi Miyamoto and Steven S. Shen
32 Genetic and Epigenetic Alterations in Renal Cell
Carcinoma 407
Fang-Ming Deng and Ming Zhou
33 Role of Needle Biopsy in Renal Masses: Past,
Present, and Future 417
Ying-Bei Chen

Part IV Update on Testicular Tumor Pathology
34 Anatomy of the Testis and Staging of its Cancers:
Implications for Diagnosis 433
Daniel M. Berney and Thomas M. Ulbright
35 Classification of Testicular Tumors 447
Cristina Magi-Galluzzi and Thomas M. Ulbright
36 Testicular Cancer Reporting on Radical Orchiectomy and
Retroperitoneal Lymph Node Dissection After Treatment 463
Daniel M. Berney
37 Difficult or Newly Described Morphologic Entities in
Testicular Neoplasia 471
Daniel M. Berney and Thomas M. Ulbright
38 Clinical Implications of the Different Histologic
Subtypes of Testicular Tumors 483
Timothy Gilligan
39 Familial Syndromes Associated with Testicular Tumors 491
Jesse K. McKenney, Claudio Lizarralde and Cristina
Magi-Galluzzi
40 Molecular and Immunohistochemical Markers of Diagnostic
and Prognostic Value in Testicular Tumors 501
Victor E. Reuter
41 Intraoperative Consultation for Testicular Tumors:
Challenges and Implications for Treatment 517
Hiroshi Miyamoto and Steven S. Shen
42 Genetic and Epigenetic Alterations in Testicular Tumors 521
Pallavi A. Patil and Cristina Magi-Galluzzi
Index 529