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This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.
Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.
Definition and Diagnosis of Sarcopenia in the Research and Clinical Settings
Pages 3-12
Montano-Loza, Aldo J. (et al.)
The Definition and Diagnosis of Frailty in the Research and Clinical Settings
Pages 13-23
Chen, Hui-Wei (et al.)
Deciphering the Cirrhotic Patient’s Present Status: The Overlap Between Physical Frailty, Disability, and Sarcopenia
Pages 25-32
Tapper, Elliot B.
The Pathogenesis of Physical Frailty and Sarcopenia
Pages 33-53
Dasarathy, Srinivasan
Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation
Pages 55-76
Buettner, Stefan (et al.)
Nutritional Therapy in the Management of Physical Frailty and Sarcopenia
Pages 77-85
Merli, Manuela (et al.)
Exercise Training in Patients with Cirrhosis
Pages 87-116
Purdy, Graeme M. (et al.)
Sex-, Age-, and Ethnicity-Dependent Variation in Body Composition: Can There Be a Single Cutoff?
Pages 119-126
Gonzalez, Maria Cristina (et al.)
Muscle Mass Versus Muscle Strength and Performance: Is Muscle Mass Measurement Alone Enough?
Pages 127-137
Kappus, Matthew R. (et al.)
The Role of Changes in Subcutaneous and Visceral Adiposity, Sarcopenic Obesity, and Myosteatosis/Muscle Quality in Cirrhosis: How to Diagnose It and Its Contribution to Prognosis
Pages 139-149
Ebadi, Maryam (et al.)
Evidence for the Assessment of Physical Frailty and Sarcopenia in Hospitalized Patients and the Role of Assessing Changes Over Time
Pages 151-159
Stirnimann, Guido
Frailty and Sarcopenia in the Selection of Candidates for Liver Transplantation
Pages 161-168
Sonnenday, Christopher J.
Physical Frailty and Sarcopenia in End-Stage Liver Disease: Do They Improve After Liver Transplantation?
Pages 169-177
Bhanji, Rahima A. (et al.)
Measures of Sarcopenia: The Utility of Ultrasound, Bioelectrical Impedance Analysis and Single-Slice Cross-Sectional Imaging
Pages 179-207
Mourtzakis, Marina (et al.)
Upcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and Sarcopenia
Pages 211-232
Hey, Penelope (et al.)
Should Frailty Include Multidimensional and Dynamic Factors?
Pages 233-246
Rolfson, Darryl B.
Hepatic Encephalopathy, Sarcopenia, and Frailty
Pages 247-263
Bémeur, Chantal (et al.)
A Research Wish List to Understand, Diagnose, and Manage Frailty and Sarcopenia
Pages 265-271
Dunn, Michael A.
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