Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.
The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner.
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Features: |
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Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
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Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
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Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.
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New To This Edition: |
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Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.
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Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors.
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16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis.
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New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place.
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In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
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Section I - Genetics and Embryology
Section II - Placenta and Intrauterine Environment
Section III - Developmental Pharmacology and Pharmacokinetics
Section IV - Intrauterine and Postnatal Growth
Section V - Perinatal Iron, Mineral, and Vitamin Metabolism
Section VI - Lipid Metabolism
Section VII - Carbohydrate Metabolism
Section VIII - Protein Metabolism
Section IX - Thermoregulation
Section X - Skin
Section XI - Fetal and Neonatal Cardiovascular Physiology
Section XII - The Lung
Section XIII - Surfactant
Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate
Section XV - Liver and Bilirubin Metabolism
Section XVI - The Kidney
Section XVII - Fluid and Electrolyte Metabolism
Section XVIII - Developmental Hematopoiesis
Section XIX - Hemostasis
Section XX - Developmental Immunobiology
Section XXI - Neurology
Section XXII - Special Sensory Systems in the Fetus and Neonate
Section XXIII - Orthopedics
Section XXIV - Endocrine Function
Section XXV - Ovary and Testis
Section XXVI - Pathophysiology of Neonatal Diseases
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Basic Genetic Principles
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Prenatal Diagnosis
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Basic Embryology
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Regulation of Embryogenesis
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The Extracellular Matrix in Development
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Stem Cell Biology
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Apoptotic Cell Death
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Angiogenesis
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Epigenetics
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Placental Development
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Regulation of the Placental Circulation
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Mechanisms of Transfer Across the Human Placenta
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Endocrine and Paracrine Function of the Human Placenta
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Fetal and Maternal Responses to Intrauterine Infection
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Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
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Physiologic Effects of Multiple Pregnancy on Mother and Fetus
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Placental function in intrauterine growth restriction
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Basic Pharmacologic Principles
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Principles of Pharmacokinetics
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Physicochemical and Structural Properties Regulating Placental Drug Transfer
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Pharmacogenetics
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Drug Distribution in Fetal Life
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Drug Transfer During Breastfeeding
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Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
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Endocrine Factors Affecting Neonatal Growth
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Human Milk Composition and Function in the Infant
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Physiology of Lactation
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Fetal and Neonatal Iron Metabolism
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Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
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Zinc in the Fetus and Neonate
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Vitamin A Metabolism in the Fetus and Neonate
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Vitamin E Metabolism in the Fetus and Newborn Infant
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Vitamin K Metabolism in the Fetus and Neonate
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Maternal-Fetal Transfer of Lipid Metabolites
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Brown Adipose Tissue: Development and Function
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Lipids as an Energy Source for the Premature and Full-Term Neonate
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Ketone Body Production and Metabolism in the Fetus and Neonate
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Long-Chain Fatty Acids in the Developing Retina and Brain
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Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
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Carbohydrate Metabolism During Pregnancy
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Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
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Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
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Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
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General Concepts of Protein Metabolism
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Fetal Requirements and Placental Transfer of Nitrogenous Compounds
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Temperature Control in Newborn Infants
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Responses of the Fetus and Neonate to Hypothermia
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Structure and Development of Skin and Cutaneous Appendages
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Physiologic Development of the Skin
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Cardiovascular Development
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Developmental Electrophysiology in the Fetus and Neonate
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Developmental Biology of the Pulmonary Vasculature
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Development of the Gastrointestinal Circulation in the Fetus and Newborn
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Physiology of Congenital Heart Disease in the Neonate
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Neural Regulation of Blood Pressure During Fetal and Newborn Life
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Developmental Effects on Fetal Circulation
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Mechanisms Regulating Closure of the Ductus Arteriosus
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Umbilical Circulation
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Fetal and Placental Circulation During Labor
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Physiology of Resuscitation
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Normal and Abnormal Structural Development of the Lung
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Regulation of Alveolarization
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Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
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Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
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Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
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Upper Airway Structure: Function, Regulation, and Development
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Regulation of Lower Airway Function
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Functional Development of Respiratory Muscles
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Mechanics of Breathing
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Pulmonary Gas Exchange in the Developing Lung
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Oxygen Transport and Delivery
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Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
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Basic Mechanisms of Oxygen Sensing and Response to Hypoxia
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Evaluation of Pulmonary Function in the Neonate
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Mechanisms of Neonatal Lung Injury
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Impaired Lung Growth After Injury in Premature Lung
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Antenatal Factors That Influence Postnatal Lung Development and Injury
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Regulation of Pulmonary Circulation
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Historical Perspective
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Composition of Pulmonary Surfactant Lipids and Proteins
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Structure And Development of Alveolar Epithelial Cells
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Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
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Hormonal Therapy for Prevention of Respiratory Distress Syndrome
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Surfactant Treatment
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Genetics and Physiology of Surfactant Protein Deficiencies
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Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
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Organogenesis of the Gastrointestinal Tract
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Development of the Enteric Nervous System
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Development of Gastric Secretory Function
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Development of Gastrointestinal Motility
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Development of the Exocrine Pancreas
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Digestive-Absorption Functions in Fetuses, Infants, and Children
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Development of the Intestinal Microbiome
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Organogenesis and Histologic Development of the Liver
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Bile Acid Metabolism During Development
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Neonatal Bilirubin Metabolism
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Hereditary Contribution to Neonatal Hyperbilirubinemia
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Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia
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Embryogenesis and Anatomic Development of the Kidney
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Functional Development of the Kidney in Utero
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Development and Regulation of Renal Blood flow in the Neonate
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Development of the Renin-Angiotensin System
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Postnatal Development of Glomerular Filtration Rate in Neonates
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Renal Transport of Sodium During Early Development
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Potassium Homeostasis in the Fetus and Neonate
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Role of the Kidney in Calcium and Phosphorus Homeostasis
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Transport of Amino Acids in the Fetus and Neonate
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Developmental Aspects of Organic Acid Transport
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Concentration and Dilution of the Urine
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Development of Acidification Mechanisms in the Fetus and Neonate
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Response to Nephron Loss in Early Development
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Fluid Distribution in the Fetus and Neonate
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Regulation of Acid-Base Balance in the Fetus and Neonate
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Developmental Biology of Stem Cells: From the Embryo to the Adult
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Developmental Granulocytopoiesis
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Developmental Erythropoiesis
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Developmental Megakaryocytopoiesis
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Developmental Hemostasis
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Platelet–Vessel Wall Interactions
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Host Defense Mechanisms Against Bacteria
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Host-Fungi Interactions Relevant to the Newborn Infant
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Host Defense Mechanisms Against Viruses
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T-Cell Development
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B-Cell Development
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Mononuclear Phagocyte System
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Normal and Abnormal Neutrophil Physiology in the Newborn
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The Complement System of the Fetus and Newborn
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Cytokines and Inflammatory Response in the Fetus and Neonate
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Immunology of Human Milk and Host Immunity
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Neonatal Pulmonary Host Defense
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Development of the Nervous System
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Development of the Blood-Brain Barrier
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Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
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Intraventricular Hemorrhage in the Neonate
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Cerebellar Development – an Impact of Preterm Birth and Co-Morbidities
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Electroencephalography in the Premature and Full-Term Infant
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Developmental Aspects of Pain
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Early Development of the Human Auditory System
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Development of Taste and Smell in the Neonate
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The Growth Plate: Embryologic Origin, Structure, and Function
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Ontogenesis of Striated Muscle
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Hypothalamus: Neuroendometabolic Center
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Growth Factor Regulation of Fetal Growth
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Growth Hormone in the Fetus and Newborn
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Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
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Development of the Corticotropin-Releasing Hormone–Corticotropin System in the Mammalian Fetus
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Fetal and Neonatal Adrenocortical Physiology
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Fetal and Neonatal Thyroid Physiology
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Genetics of Sex Determination and Differentiation
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Differentiation of the Ovary
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Testicular Development and Descent
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Pathophysiology of Neonatal sepsis
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Pathophysiology of Hypoglycemia in the Neonate
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Pathophysiology of Cardiomyopathies
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Pathophysiology of Persistent pulmonary hypertension of the newborn
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Pathophysiology of Shock in the Fetus and Neonate
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Pathophysiology of Apnea of Prematurity
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Pathophysiology of Respiratory Distress Syndrome
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Pathophysiology of Meconium Aspiration Syndrome
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Pathophysiology of Bronchopulmonary Dysplasia
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Pathophysiology of Ventilator Dependent Infants
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Pathophysiology of Gastroesophageal Reflux
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Pathophysiology of Neonatal Necrotizing Enterocolitis
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Pathophysiology of Kernicterus
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Pathophysiology of neonatal acute kidney injury
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Pathophysiology of Edema
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Pathophysiology of Retinopathy of Prematurity
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Pathophysiology of Hypoxic-ischemic Brain Injury
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Pathophysiology of Neonatal White Matter Injury
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Pathophysiology of Meningitis
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Pathophysiology of Neural Tube Defects
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Pathophysiology of Preeclampsia
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Pathophysiology of Preterm Birth
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Pathophysiology of Chorioamnionitis