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Introduction: Childhood Leukemia
Pages 1-48
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Etiology of Acute Leukemias in Children
Mejía-Aranguré
Editore
Springer
Anno
2016
Pagine
320
ISBN
9783319057972
140,00 €
Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theories and hypothesis regarding childhood acute leukemia. Written by the most outstanding researchers in the field, this book intends to contribute to a greater understanding of the etiology of this disease. It goes beyond the simple and common analysis of risk factors, which hardly allows us to draw definite conclusions. By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children. The knowledge regarding etiology is a crucial step for a better evaluation, prevention and treatment of a disease. Thus, this book finally intends to provide such knowledge, allowing physicians and practitioners to a better manage of childhood acute leukemias.
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Etiology and Prevention of Acute Leukemias in Children
Pages 49-74
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HTLV-1 as a Model for Identifying the Causes of Human Leukemia
Pages 75-88
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Etiology of Leukemia in Children with Down Syndrome
Pages 89-108
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Origin of Leukemia in Children with Down Syndrome
Pages 109-131
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Model for the Origin of Acute Leukemias in Children: Interaction of Three Factors—Susceptibility, Exposure, and Window of Vulnerability
Pages 133-155
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Molecular Origin of Childhood Acute Lymphoblastic Leukemia
Pages 157-206
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Environmental Factors and Exposure Time Windows Related to the Etiology of Acute Lymphoblastic Leukemia in Children
Pages 207-290
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Early Hematopoietic Differentiation in Acute Lymphoblastic Leukemia: The Interplay Between Leukemia-Initiating Cells and Abnormal Bone Marrow Microenvironment
Pages 291-318
