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Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine
Pages 3-10
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.
Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine
Pages 3-10
The Arterial Epicardium: A Developmental Approach to Cardiac Disease and Repair
Pages 11-18
Cell Sheet Tissue Engineering for Heart Failure
Pages 19-24
Future Treatment of Heart Failure Using Human iPSC-Derived Cardiomyocytes
Pages 25-31
Congenital Heart Disease: In Search of Remedial Etiologies
Pages 33-45
Left-Right Asymmetry and Human Heterotaxy Syndrome
Pages 49-56
Roles of Motile and Immotile Cilia in Left-Right Symmetry Breaking
Pages 57-65
Role of Cilia and Left-Right Patterning in Congenital Heart Disease
Pages 67-79
Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome
Pages 81-82
Single-Cell Expression Analyses of Embryonic Cardiac Progenitor Cells
Pages 85-91
Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest
Pages 93-101
Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway
Pages 103-114
The Epicardium in Ventricular Septation During Evolution and Development
Pages 115-123
S1P-S1p2 Signaling in Cardiac Precursor Cells Migration
Pages 125-126
Myogenic Progenitor Cell Differentiation Is Dependent on Modulation of Mitochondrial Biogenesis through Autophagy
Pages 127-128
The Role of the Thyroid in the Developing Heart
Pages 129-130
Atrioventricular Valve Abnormalities: From Molecular Mechanisms Underlying Morphogenesis to Clinical Perspective
Pages 135-143
Molecular Mechanisms of Heart Valve Development and Disease
Pages 145-151
A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase
Pages 153-160
The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse
Pages 161-167
TMEM100: A Novel Intracellular Transmembrane Protein Essential for Vascular Development and Cardiac Morphogenesis
Pages 169-170
The Role of Cell Autonomous Signaling by BMP in Endocardial Cushion Cells in AV Valvuloseptal Morphogenesis
Pages 171-173
Properties of Cardiac Progenitor Cells in the Second Heart Field
Pages 177-182
Nodal Signaling and Congenital Heart Defects
Pages 183-192
Utilizing Zebrafish to Understand Second Heart Field Development
Pages 193-199
A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”
Pages 201-209
The Loss of Foxc2 Expression in the Outflow Tract Links the Interrupted Arch in the Conditional Foxc2 Knockout Mouse
Pages 211-213
Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice
Pages 215-217
Extracellular Matrix Remodeling in Vascular Development and Disease
Pages 221-226
The “Cardiac Neural Crest” Concept Revisited
Pages 227-232
Roles of Endothelial Hrt Genes for Vascular Development
Pages 233-235
Inositol Trisphosphate Receptors in the Vascular Development
Pages 237-239
Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice
Pages 241-242
Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing?
Pages 245-251
The Multiple Roles of Prostaglandin E
Pages 253-258
Developmental Differences in the Maturation of Sarcoplasmic Reticulum and Contractile Proteins in Large Blood Vessels Influence Their Contractility
Pages 259-261
Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel
Pages 263-265
Regulation of Vertebrate Conduction System Development
Pages 269-280
Cardiac Pacemaker Development from a Tertiary Heart Field
Pages 281-288
Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation
Pages 289-290
Specific Isolation of HCN4-Positive Cardiac Pacemaking Cells Derived from Embryonic Stem Cells
Pages 291-292
Combinatorial Functions of Transcription Factors and Epigenetic Factors in Heart Development and Disease
Pages 295-303
Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells
Pages 305-312
Noncoding RNAs in Cardiovascular Disease
Pages 313-317
Human Pluripotent Stem Cells to Model Congenital Heart Disease
Pages 321-327
Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes
Pages 329-336
Dissecting the Left Heart Hypoplasia by Pluripotent Stem Cells
Pages 337-339
Lentiviral Gene Transfer to iPS Cells: Toward the Cardiomyocyte Differentiation of Pompe Disease-Specific iPS Cells
Pages 341-343
Molecular Analysis of Long-Term Cultured Cardiac Stem Cells for Cardiac Regeneration
Pages 345-347
Minor Contribution of Cardiac Progenitor Cells in Neonatal Heart Regeneration
Pages 349-351
Genetic Discovery for Congenital Heart Defects
Pages 355-360
Evidence That Deletion of ETS-1, a Gene in the Jacobsen Syndrome (11q-) Cardiac Critical Region, Causes Congenital Heart Defects through Impaired Cardiac Neural Crest Cell Function
Pages 361-369
Notch Signaling in Aortic Valve Development and Disease
Pages 371-376
To Detect and Explore Mechanism of CITED2 Mutation and Methylation in Children with Congenital Heart Disease
Pages 377-378
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