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Essentials of Neuroanesthesia
Prabhakar
Editore
Academic Press
Anno
2017
Pagine
1036
ISBN
9780128052990
185,00 €

DA SCONTARE

I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

Features:

  • Offers useful insights on the anesthetic management of neurosurgical and neurologic patients
  • Discusses related issues, such as palliative care, evidence based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues
  • Useful for trainees, clinicians, and researchers in the fields of neurosurgery, neurocritical care, neuroanesthesia, and neurology

Section I. Neuroanatomy

Chapter 1. Neuroanatomy

  • Introduction
  • Embryological Differentiation of Different Parts of Brain
  • Anatomy of Brain
  • Vascular Supply of the Brain
  • The Meninges and Cerebrospinal Fluid

Chapter 2. Neuroembryology

  • Formation of Zygote
  • Formation of Blastocyst
  • Formation of Embryonic or Germ Disc
  • Formation of Definitive Notochord
  • Development of Nervous System

Chapter 3. Blood-Brain Barrier

  • Introduction
  • Permeability at the Blood-Brain Barrier
  • Cellular and Molecular Effects of Anesthetics on the Blood-Brain Barrier
  • Clinical and Experimental Implications of Anesthetics on the Blood-Brain Barrier
  • Conclusion

Section II. Neurophysiology

Chapter 4. Neurophysiology

  • Intracranial Pressure
  • Normal Intracranial Pressure
  • Cerebral Compliance
  • Importance of Intracranial Pressure
  • Summary
  • Cerebral Blood Flow
  • Vascular Anatomy
  • Summary
  • Brain Metabolism
  • Normal Cerebral Metabolism
  • Summary
  • Cerebrospinal Fluid
  • Ventricular System
  • Summary
  • The Spinal Cord
  • Anatomy
  • Organization of the Spinal Cord
  • Summary

Chapter 5. Brain Protection in Neurosurgery

  • Introduction
  • Nonpharmacological Strategies
  • Mild Hypothermia
  • Blood Pressure Control
  • Induced Arterial Hypertension
  • Normoglycemia
  • Target Hemoglobin Concentration
  • Pharmacological Strategies
  • Nonanesthetic Agents
  • Anesthetic Agents
  • Conclusion

Section III. Neuropharmacology

Chapter 6. Neuropharmacology

  • Anesthetic Drugs and Sedatives
  • Intravenous Anesthetic Agents
  • Inhalational Anesthetic Agents
  • Neuromuscular Blocking Agents
  • Local Anesthetic Agents
  • Miscellaneous Drugs
  • Future Directions in Neuropharmacology
  • Conclusion

Chapter 7. Anesthetic Agents: Neurotoxics or Neuroprotectives?

  • Introduction
  • Pharmacological Considerations
  • Anesthesia Practice: Clinical Outcomes
  • Anesthesia and Fragile Brain
  • Conclusion
  • Abbreviations

Section IV. Neuromonitoring

Chapter 8. Neuromonitoring

  • Introduction
  • Cerebral Blood Flow
  • Transcranial Sonography
  • Thermal Diffusion Flowmetry
  • Laser Doppler Flowmetry
  • Intra-Arterial 133Xenon
  • CT Perfusion
  • Xenon Enhanced CT
  • Positron Emission Tomography
  • Single Photon Emission Computed Tomography
  • Magnetic Resonance Imaging
  • Intracranial Pressure
  • Electroencephalogram
  • Evoked Potential Monitoring
  • Motor Evoked Potentials
  • Depth of Anesthesia
  • Cerebral Oxygenation Monitoring
  • Jugular Venous Oximetry
  • Regional Cerebral Oximetry
  • Brain Tissue Oxygen Monitoring
  • Cerebral Microdialysis
  • Conclusion

Chapter 9. Multimodal Monitoring

  • Introduction
  • Temperature
  • Oxygen Transport, Hemodynamics, and Brain Metabolism
  • Intracranial Pressure Monitoring
  • Electroencephalography and Depth of Anesthesia Monitoring
  • Miscellaneous
  • Integration of Information and Decision-Helping Systems
  • Clinical Pearls

Section V. Positions in Neurosurgery

Chapter 10. Positioning in Neurosurgery

  • Introduction
  • Historical Background
  • Principles of Positioning
  • The Conduct of Positioning
  • Surgical Approach for Craniotomies
  • Positioning for Craniotomy
  • Positions Used for Craniotomies
  • Surgical Approach for Procedures of the Spine
  • Conclusion
  • Abbreviations

Section VI. Preanesthetic Evaluation

Chapter 11. Preanesthetic Evaluation of Neurosurgical Patients

  • Introduction
  • Preoperative Evaluation of Patient-Related Risk Factors
  • Preoperative Evaluation of Specific Neurosurgical Conditions

Section VII. Neurosurgery

Chapter 12. Supratentorial Lesions

  • Introduction
  • Classification
  • Pathophysiology and Clinical Correlations
  • Clinical Features
  • Neuroimaging
  • Intraoperative Considerations: The Team Approach
  • Anesthetic Management
  • Intraoperative Management
  • Emergence From Anesthesia
  • Postoperative Management
  • Awake Craniotomy
  • Conclusions

Chapter 13. Emergence From Anesthesia

  • Introduction
  • Neurophysiological Response During Emergence in Neurosurgical Patients
  • Specific Perioperative Considerations
  • Delayed Emergence and Arousal
  • Complications
  • Conclusion

Chapter 14. Anesthesia for Posterior Fossa Surgery

  • Introduction
  • Anatomy
  • Clinical Presentation
  • Perioperative Management of Patients for Posterior Fossa Surgery
  • Venous Air Embolism
  • Postoperative Management
  • Complications
  • Abbreviations

Chapter 15. Transesophageal Echocardiography

  • Introduction
  • Basics of Transesophageal Echocardiography
  • Summary

Chapter 16. Anesthesia for Epilepsy Surgery

  • Introduction
  • Surgical Management of Epilepsy
  • Types of Surgical Treatment
  • Presurgical Evaluation
  • Anesthesia for Epilepsy Surgery
  • Effect of Anesthetic Agents in Patients With Epilepsy
  • Antiepileptic Drug Interactions
  • Preanesthetic Evaluation and Preparation
  • Anesthetic Management of Preoperative Procedures
  • Anesthesia for Intracranial Electrode Insertion
  • Anesthetic Management of Resection of Seizure Focus
  • Awake Craniotomy
  • Resection of Epileptogenic Focus Under General Anesthesia
  • Neurostimulation for Drug-Resistant Epilepsy
  • Anesthetic Management of the Patient With Epilepsy for Incidental Surgery
  • Abbreviations

Chapter 17. Refractory Status Epilepticus

  • Introduction
  • Epidemiology
  • Classification
  • Cause
  • Pathophysiology
  • Diagnosis
  • Management
  • Treatment
  • Conclusions

Chapter 18. Aneurysmal Subarachnoid Hemorrhage

  • History
  • Introduction
  • Clinical Presentation and Diagnosis
  • Grading of Subarachnoid Hemorrhage
  • Initial Management Concerns in Neurocritical Care Unit
  • Timing of Surgery
  • Clipping or Coiling
  • Evaluation of a Patient With Subarachnoid Hemorrhage for Anesthesia
  • Anesthetic Management
  • Temporary Clipping and Brain Protection Strategy
  • Intraoperative Aneurysm Rupture
  • Giant Aneurysms and Circulatory Arrest
  • Endovascular Management for Aneurysm Ablation
  • Postoperative Management of Patients
  • Conclusion

Chapter 19. Circulatory Arrest

  • Introduction
  • Deep Hypothermic Circulatory Arrest
  • Anesthesia Management
  • Complications
  • Adenosine-Induced Circulatory Arrest
  • Anesthesia Considerations
  • Complications
  • Summary

Chapter 20. Cerebrovascular Disease

  • Intracerebral Hemorrhage
  • Incidence and Risk Factors
  • Imaging
  • Clinical Presentation
  • Management of Intracerebral Hemorrhage
  • Arteriovenous Malformations
  • Cause and Incidence
  • Natural History
  • Pathophysiologic Effects and Clinical Presentation
  • Grading of Arteriovenous Malformations
  • Imaging
  • Cerebral Hemodynamics in Arteriovenous Malformation
  • Management
  • Surgical Resection of Arteriovenous Malformation
  • Anesthetic Considerations for Resection of Arteriovenous Malformation
  • Postoperative Management
  • Anesthetic Considerations for Arteriovenous Malformation Embolization
  • Complications During Arteriovenous Malformation Embolization
  • Pediatric Arteriovenous Malformations
  • Pregnancy and Arteriovenous Malformations
  • Vein of Galen Aneurysmal Malformations
  • Dural Arteriovenous Fistula
  • Clinical Presentation
  • Management
  • Carotid Endarterectomy
  • Preoperative Evaluation
  • Management of Carotid Artery Disease
  • Monitoring
  • Intraoperative Management
  • Postoperative Complications and Outcomes
  • Coronary Angioplasty and Stenting
  • Moyamoya Disease
  • Management of Moyamoya Disease

Chapter 21. Flow Arrest in Cerebrovascular Surgery

  • Deep Hypothermic Circulatory Arrest
  • Adenosine-Assisted Cerebral Blood Flow Arrest
  • Rapid Ventricular Pacing-Assisted Cerebral Blood Flow Arrest

Chapter 22. Neuroendocrine Lesions

  • Hypothalamic-Pituitary-Adrenal Axis Evaluation
  • Neuroendocrine Response Related to Anesthesia and Surgery
  • Pituitary Gland Adenomas
  • Physiology of Pituitary Gland
  • Endocrine Diseases
  • Nonfunctioning Tumors
  • Intraoperative Considerations
  • Advantages of Endoscopic Endonasal Approach
  • Relative Contraindications to Transsphenoidal Approach
  • Intraoperative Issues
  • Disorder of Water and Electrolytes

Chapter 23. Pituitary Apoplexy

  • Clinical Features
  • Management

Chapter 24. Spinal Surgery

  • Introduction
  • Spine
  • Types of Spine Surgeries
  • Surgical Approaches to the Spine
  • Common Spine Disorders
  • Imaging in Spine Lesions
  • Positioning for Spine Surgeries
  • Neurophysiological Intraoperative Monitoring During Spine Surgeries
  • Preanesthetic Assessment and Optimization
  • Anesthesia Management
  • Postoperative Management
  • Special Considerations
  • Conclusion

Chapter 25. Postoperative Visual Loss

  • Introduction
  • Central Retinal Artery Occlusion
  • Ischemic Optic Neuropathy
  • Cortical Blindness
  • Recent Advances
  • Conclusion

Chapter 26. Neuroendoscopy

  • Introduction
  • Anesthetic Goals and Management
  • Anesthetic Management of Specific Neuroendoscopic Procedures
  • Advances in Neuroendoscopy
  • Conclusion
  • Clinical Pearls

Chapter 27. Pressure Inside the Neuroendoscope

  • Introduction
  • Indications and Procedures
  • How Do Neurosurgeons Perform an Intraventricular Endoscopic Procedure?
  • Anesthetic Procedure: What to Take Into Account?
  • Perioperative Complications
  • Conclusion

Chapter 28. Anesthesia for Functional Neurosurgery

  • Introduction
  • Procedure
  • Anesthetic Consideration
  • Anesthetic Techniques
  • Complications
  • Anesthesia in Patients With Deep Brain Stimulator In Situ
  • Conclusion

Chapter 29. Awake Craniotomy

  • Introduction
  • Patient Selection
  • Awake Craniotomy for Tumor Surgery
  • Awake Craniotomy for Epilepsy
  • Conclusion

Section VIII. Neuroradiology

Chapter 30. Anesthesia for Neuroradiology

  • Introduction
  • Issues Relating to Anesthesia Care in Neuroradiology
  • Anesthesia for Computed Tomographic Study
  • Anesthesia for Magnetic Resonance Imaging Study
  • Anesthesia for Diagnostic Angiography
  • Anesthetic Management of Endovascular Coiling
  • Anesthetic Management of Endovascular Embolization of Arteriovenous Malformation, Arteriovenous Fistula, and Vein of Galen Malformation
  • Anesthesia for Stroke Interventions
  • Issues Related to Radiation During Neurointervention
  • Anesthesia for Stereotactic Radiosurgery
  • Pregnancy and Neuroradiology
  • Clinical Pearls

Chapter 31. Magnetic Resonance Imaging: Anesthetic Implications

  • Introduction: The Road From X-Ray to Magnetic Resonance Imaging
  • Principles of Nuclear Magnetic Resonance and Magnetic Resonance Imaging
  • Various Types of Signals Recorded
  • Hazards Related to Magnetic Resonance Imaging
  • Magnetic Resonance Imaging Safety: General Considerations
  • Magnetic Resonance Imaging Safety: Management of Cardiac Implantable Electronic Devices and Other Implantable Devices
  • Anesthesia for Magnetic Resonance Imaging
  • Research Applications/Emerging Clinical Applications of Magnetic Resonance Imaging

Section IX. Neurotrauma

Chapter 32. Neurotrauma

  • Traumatic Brain Injury
  • Definition
  • Epidemiology
  • Classification of Traumatic Brain Injury
  • Physiologic Response to Brain Injury
  • Neuroimaging
  • Severity of Traumatic Brain Injury
  • Management of Traumatic Brain Injury
  • Outcome
  • Emerging Treatment Modalities
  • Conclusion
  • Spine and Spinal Cord Trauma
  • Epidemiology
  • Classification of Spinal Injury
  • Pathophysiology of Spinal Cord Trauma
  • Systemic Complications of Spinal Cord Injuries
  • Management of Spine and Spinal Cord Injury
  • Emerging Treatment Modalities

Chapter 33. Biomarkers in Traumatic Brain Injury

  • Introduction
  • Conclusion

Section X. Neurointensive Care

Chapter 34. Neurological Critical Care

  • Introduction
  • History of Neurocritical Care
  • Design of a Neurocritical Care Unit
  • Clinical Conditions Requiring Admission to Neurocritical Care Unit
  • Justification for Neurological Critical Care Units
  • Pathophysiological Issues in Neurological Critical Care
  • Management of Patients in a Neurological Intensive Care Unit
  • Management of General Systemic Physiology
  • Specific Therapeutic Issues in Individual Clinical Conditions
  • Advanced Neuromonitoring
  • Outcomes of Neurological Intensive Care Unit
  • End-of-Life Issues in Neurological Critical Care
  • Clinical Pearls

Chapter 35. Antibiotics: Prophylactic and Therapeutics

  • Introduction
  • Principles of Antimicrobial Therapy in Neurosurgery
  • Treatment of Central Nervous System Infections in the Neurosurgical Patient
  • Antimicrobial Prophylaxis in Neurosurgery

Section XI. Special Considerations

Chapter 36. Pediatric Neuroanesthesia

  • Overview
  • Pediatric Neurophysiology
  • General Principles of Pediatric Neuroanesthesia
  • Intraoperative Management
  • Postoperative Considerations
  • Management of Specific Conditions
  • Conclusion

Chapter 37. Fluid and Blood Transfusion in Pediatric Neurosurgery

  • Introduction
  • Fluid and Electrolyte Choices
  • Type of Fluids for Perioperative Administration in Pediatric Patients
  • Fluid Management in Pediatric Neurosurgery
  • Osmotherapy
  • Fluid and Electrolyte Disturbances in Pediatric Neurosurgery
  • Blood Transfusion
  • Blood Components
  • Special Situations
  • Epilepsy Surgery
  • Scoliosis
  • Conclusion

Chapter 38. Geriatric Neuroanesthesia

  • Introduction
  • Implications of Surgical Stress and Anesthesia on the Elderly
  • Neurosurgical Concerns Unique to the Elderly
  • Conclusion

Chapter 39. Postoperative Cognitive Dysfunction

  • Introduction
  • Definitions, Epidemiology, and Pathophysiology
  • Risk Factors
  • Prevention
  • Screening Tools
  • Treatment
  • Outcome

Chapter 40. Pregnancy

  • Requirement of Neurosurgery During Pregnancy
  • Physiological Alterations During Pregnancy
  • Effect of Anesthetic Agents on Fetal Outcome
  • Uteroplacental Drug Transfer and Neonatal Depression
  • Timing and Method of Delivery
  • Anesthetic Considerations During Pregnancy
  • Induction: Rapid Sequence Versus Slow Neuroinduction
  • Combined Cesarean Delivery and Neurosurgery
  • Intracranial Pressure and Regional Anesthesia
  • Postoperative Management
  • Anesthesia for Interventional Neurosurgical Procedures

Chapter 41. Cerebral Venous Thrombosis

  • Definition
  • Venous Anatomy
  • Incidence of Cerebral Venous Thrombosis
  • Risk Factors
  • Pathophysiology
  • Clinical Manifestations
  • Diagnostic Evaluation
  • Treatment
  • Anesthetic Management
  • Prognosis
  • Conclusion

Chapter 42. Neurosurgical Anesthesia in Patients With Coexisting Cardiac Disease

  • Introduction
  • Preoperative Evaluation
  • Risk Stratification
  • Perioperative Monitoring
  • Ischemic Heart Disease
  • Valvular Heart Disease
  • Tumors of the Heart
  • Congenital Heart Disease
  • Hypertension
  • Conclusion

Chapter 43. Intraoperative Cardiopulmonary Resuscitation

  • Introduction
  • Incidence, Morbidity, and Mortality
  • Survival From Intraoperative Cardiac Arrest
  • Predictors
  • Cause of Intraoperative Cardiac Arrest
  • Cardiopulmonary Resuscitation Quality
  • Cardiac Arrest and Cardiopulmonary Resuscitation in Neurosurgical Patients
  • Prognosis
  • Conclusion

Chapter 44. Coexisting Diabetes Mellitus in Neurosurgical Patients

  • Introduction
  • Incidence of Diabetes Mellitus
  • Glycemic Indices
  • Modes of Glucose Measurement
  • Pathophysiology of Diabetes Mellitus
  • Cerebral Glucose Metabolism
  • Hyperglycemia and the Brain
  • Hyperglycemic Neuropathy
  • Diabetic Dysautonomia
  • Hypoglycemia and the Brain
  • Evidence of Glycemic Control in Important Neurosurgical Subsets
  • Traumatic Brain Injury
  • Subarachnoid Hemorrhage
  • Cerebrovascular Accidents
  • Tumor Surgery
  • Spine Surgery
  • Blood Sugar Management in Perioperative Period and Neurocritical Care
  • Intraoperative Management
  • Anesthetic Management
  • Postoperative Glycemic Management
  • Blood Sugar Control in Emergency Neurosurgical Patient
  • Blood Sugar Control in Intensive Care Setup
  • Nutrition
  • Conclusions
  • Coexisting Hypertension in Neurosurgical Patients
  • Physiology of Cerebral Circulation
  • Pathophysiology of Arterial Hypertension
  • Hypertension in Patients With Traumatic Brain Injury
  • Perioperative Management
  • Preoperative Evaluation
  • Antihypertensive Drugs
  • Intraoperative Management
  • Monitoring
  • Induction of Anesthesia
  • Maintenance of Anesthesia
  • Recovery From Anesthesia
  • Postoperative Care
  • Neurocritical Care
  • Conclusion

Chapter 45. Neuromuscular Disorders

  • Introduction
  • Myasthenia Gravis
  • Myasthenic Crisis
  • Lambert-Eaton Myasthenic Syndrome
  • Guillain-Barré Syndrome
  • Periodic Paralysis
  • Myotonias
  • Muscular Dystrophies
  • Motor Neuron Diseases
  • Multiple Sclerosis
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Huntington’s Disease

Chapter 46. Neuromuscular Electrical Stimulation in Critically Ill Patients

  • Introduction
  • Neuromuscular Electrical Stimulation: Basic Concepts and Practical Considerations
  • Neuromuscular Electrical Stimulation in the Intensive Care Unit
  • Contraindications and Adverse Effects
  • Recommendations for the Use of Neuromuscular Electrical Stimulation in the Intensive Care Unit

Chapter 47. Neurological Patients for Nonneurosurgeries

  • Neurodegenerative Diseases
  • Demyelinating Disease
  • Neuromuscular Disease: Myasthenia Gravis
  • Epilepsy
  • Intracranial Tumors
  • Traumatic Brain Injury

Chapter 48. Anesthesia for Electroconvulsive Therapy

  • Background
  • Technique of Electroconvulsive Therapy
  • Contraindications
  • Preprocedure Management
  • Anesthesia for Electroconvulsive Therapy
  • Side Effects
  • Special Conditions
  • Conclusion

Section XII. Fluids and Electrolyte Management

Chapter 49. Fluids and Electrolyte Management

  • Introduction
  • Anatomy and Physiology
  • Pathophysiology
  • Definitions
  • Choice of Fluids
  • Hypertonic Fluids
  • Isotonic Fluids
  • Colloids
  • Hypotonic Fluids
  • Fluid Management
  • Commonly Encountered Fluid Abnormalities
  • Conclusion
  • Clinical Pearls

Chapter 50. Crystalloid and Colloid Fluids

  • Crystalloid Fluids
  • Colloid Fluids
  • Which Fluid to Choose?
  • Conclusions

Section XIII. Pain Management

Chapter 51. Pain Management

  • Postcraniotomy Pain
  • Incidence
  • Anatomical and Physiological Basis of Pain Following Craniotomy
  • Pain-Sensitive Structures of Cranium
  • Pathogenesis of Postcraniotomy Pain
  • Factors Affecting Postcraniotomy Pain
  • Classification and Assessment of Postcraniotomy Pain
  • Preemption of Pain
  • Treatment of Acute Pain
  • Postcraniotomy Pain Management in the Pediatric Population
  • Conclusion
  • Acute Pain Management After Spinal Surgery
  • Pathophysiology
  • Treatment Modalities for Acute Postoperative Spinal Pain
  • Conclusion

Section XIV. Brain Death and Ethical Issues

Chapter 52. Brain Death and Ethical Issues in Neuroanesthesia Practice

  • Part A: Brain Death
  • Criteria for Diagnosing Death
  • Need for Brain Death Diagnosis
  • Rules Regulating Diagnosis of Brain Death
  • Criteria for Certifying Brain Stem Death
  • Pitfalls/Controversies
  • Conclusion
  • Appendix I
  • Part B: Ethical Issues in Neuroanesthesia Practice
  • Ethical Issues in Clinical Care
  • Ethical Issues Related to Research
  • Ethical Issues Related to Team Work
  • Ethical Issues Related to Training
  • Ethical Issues Related to Innovative Neurosurgery
  • Conclusion

Chapter 53. Organ Donation

  • Introduction
  • Conclusion

Section XV. Evidence-Based Practice

Chapter 54. Evidence-Based Practice of Neuroanesthesia

  • Introduction
  • Evidence-Based Practice and Neuroanesthesia
  • Evidence and the Brain Trauma Foundation Guidelines
  • Unresolved Issues in the Practice of Neuroanesthesia
  • Conclusion
  • Clinical Pearls

Chapter 55. Translational Research

  • Introduction
  • Definition
  • In Neuroanesthesia
  • Why Not Lead to Clinical
  • To Be a Successful Translation
  • Conclusion

Section XVI. Recent Advances

Chapter 56. Recent Advances in Neuroanesthesiology

  • Introduction
  • Endovascular Treatment of Stroke and Perioperative Stroke
  • Indications for Deep Brain Stimulation
  • Anesthetic Neurotoxicity
  • Pre- and Postconditioning
  • Brain Monitoring
  • New Assays for Creutzfeldt-Jakob Disease

Chapter 57. Stem Cell Therapy

  • Hypothesis of Stem Cell Research
  • Stem Cell
  • Historical Background
  • Types of Stem Cells
  • Sources of Stem Cells
  • Mesenchymal Stem Cells
  • Stem Cells in Neurological Diseases
  • Mode of Action of Stem Cell Therapy
  • Ethical Issues
  • Recent Advances

Chapter 58. Pharmacogenomics

  • Introduction
  • Basic Genetic Principles
  • Basic Pharmacologic Principles
  • Anesthesia Contribution to the History of Pharmacogenomics
  • Pharmacogenomics: Current Application to Clinical Anesthesia
  • Conclusion

Section XVII. Sterilization Techniques

Chapter 59. Sterilization and Disinfection

  • Background
  • Recommendation of Preferred Methods for Various Medical Devices
  • Recommendation for the Cleaning and Decontamination of Environmental Surfaces
  • Recommendation for Blood Spill on the Surface
  • Cleaning and Disinfection of Medical Instruments
  • Cleaning and Reprocessing of Patient Care Equipment
  • Reprocessing of Respiratory Apparatus and Endoscopes
  • Reprocessing of Endoscopes
  • Specific Issues
  • Special Precaution for Inactivation of Creutzfeldt-Jakob Disease
  • Health Care-Associated Infections
  • Infections in Operating Rooms and Intensive Care Units
  • Conclusion

Chapter 60. Universal Precautions in the Intensive Care Unit

  • Introduction
  • Prophylactics of Health Care-Associated Infections in the Intensive Care Unit
  • Early Diagnosis of Pathogens and Infection Complications in the Intensive Care Unit
  • Rational Antibiotic Therapy
  • Systemic Approach
  • Conclusion

Section XVIII. Palliative Care

Chapter 61. Palliative Care to Neurological and Neurosurgical Patients

  • Introduction

Chapter 62. Quality of Life and Health-Related Issues

  • Introduction
  • Quality of Life and Health-Related Quality of Life
  • Utility of Health-Related Quality of Life
  • Tools for Measuring Health-Related Quality of Life
  • Uses of Measuring Health-Related Quality of Life
  • Health-Related Quality of Life in Relation to Neurosurgical/Neurological Conditions
  • Conclusion

Section XIX. Biostatistics

Chapter 63. Biostatistics

  • Introduction to Biostatistics
  • Definition of Statistics
  • Biostatistics and Its Applications
  • Uses of Statistical Methods in Medical Sciences
  • Some Basic Statistical Concepts
  • Population and Sample
  • Scale of Measurements
  • Constant
  • Variables
  • Parameter and Statistic
  • Ratio, Proportion, and Rate
  • Statistical Inference
  • Estimation
  • Hypothesis Testing
  • Steps in Hypothesis Testing or Testing the Statistical Significance
  • Defining the Null and Alternative Hypotheses
  • Calculating the Test Statistic
  • Obtaining, Using, and Interpreting the p-Value
  • Errors in Hypothesis Testing
  • The Possible Mistakes We Can Make
  • Other Important Concepts That are Essential in Statistical Inference
  • Parametric and Nonparametric Statistical Methods
  • Basic Principles of Statistics
  • Probability Distributions
  • Study Design
  • Sample Size
  • Data Collection and Preparing Data for Analysis
  • Analysis and Presentation of Data
  • Summarizing Data
  • Comparing Groups: Continuous Data
  • Comparing Groups: Categorical Data
  • Comparing Groups: Time to Event Data
  • Relation Between Two Continuous Variables
  • Multivariable Analysis
  • Conclusion
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