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Libreria medica internazionale
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Eosinophil Ultrastructure
Atlas of Eosinophil Cell Biology and Pathology
Melo et al
Editore
Elsevier
Anno
2022
Pagine
518
ISBN
9780323994132
105,00 €

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Features:
  • Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses
  • Provides a core of essential knowledge to identify both immature and mature eosinophils
  • Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions
  • Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects
  • Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies
  • Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils

SECTION I - THE CELL BIOLOGY OF HUMAN EOSINOPHILS
Chapter 1 Introduction

Chapter 2 Mature Eosinophils - General Morphology
2.1 Overview
2.2 Nucleus
2.3 Secretory Granules
2.4 Lipid Bodies
2.5 Eosinophil Sombrero vesicles (EoSVs)
2.6 Other Organelles and Structures
2.6.1 Endoplasmic Reticulum

Chapter 3 Eosinophils as Secretory Cells
3.1 Overview
3.2 Classical and Compound Exocytosis
3.3 Piecemeal Degranulation
3.4 Cytolysis
3.5 Extracellular Vesicles Production

Chapter 4 Eosinophil Activation
4.1 Overview
4.2 Ultrastructural Changes of Secretory Granules
4.3 EoSV Formation
4.4 Lipid Body Formation
4.5 Shape Changes
4.6 Extracellular Vesicle Production

Chapter 5 Subcellular Localization of Immune Mediators and other Proteins
5.1 Overview
5.2 Major Basic Protein
5.3 Cytokines
5.4 Receptors
5.5 Tetraspanins
5.6 Galectin-10
5.7 Enzymes Involved in the Formation of Leukotrienes

Chapter 6 Eosinophil Cell Death
6.1 Overview
6.2 Cytolytic Morphology - General Aspects
6.3 Cytolytic Morphology - ETosis
6.4 Apoptotic Morphology - General Aspects

Chapter 7 Immature Eosinophils
7.1 Overview
7.2 About Immature and Mature Eosinophil Granules
7.3 Maturation stages of human eosinophils characterized by TEM

SECTION II - EOSINOPHILS IN HUMAN DISEASES
Chapter 8 Eosinophil-associated diseases
8.1 Overview
8.2 Allergic Airway Diseases
8.3 Skin Disorders
8.4 Hypereosinophilic Syndrome (HES)
8.5 Eosinophilic Granulomatosis with Polyangiitis (EGPA)
8.6 Gastrointestinal Disorders
8.7 Infectious Diseases
8.8 Tumors
8.9 Charcot-Leyden Crystals (CLCs) Formation

SECTION III - THE CELL BIOLOGY OF MOUSE EOSINOPHILS
Chapter 9 Ultrastructure of Mouse Eosinophils
9.1 Overview
9.2 Mature Mouse Eosinophils: General Morphology
9.3 Immature Mouse Eosinophils
9.4 Activation and Degranulation of Mouse Eosinophils
9.5 Mice in the Context of EADs

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