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Treatment of Dupuytren Disease in Different Countries: A Welcome Address from the President of IFSSH
Pages 3-9
In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.
Treatment of Dupuytren Disease in Different Countries: A Welcome Address from the President of IFSSH
Pages 3-9
The Epidemiology of Surgical Intervention for Dupuytren Contracture in England
Pages 11-15
Favorite Options of German Hand Surgeons in the Treatment of Dupuytren Disease
Pages 17-21
Trends in Dupuytren Treatment in the United States
Pages 23-27
International Patient Survey (Part 1: Dupuytren Disease)
Pages 29-40
The Extracellular Matrix in Dupuytren Disease
Pages 43-54
Biomarkers of Postsurgical Outcome in Dupuytren Disease
Pages 55-61
Tumour Necrosis Factor as a Therapeutic Target in Dupuytren Disease
Pages 63-71
Contraction Versus Contracture: Considerations on the Pathogenesis of Dupuytren Disease
Pages 73-81
Controversy: The Contracture in Dupuytren Disease Is an Active Process
Pages 83-87
Controversy: The Contracture in Dupuytren Disease Is a Passive Process
Pages 89-96
Human Genetic Studies of Dupuytren Disease: A Primer
Pages 99-103
Network Analysis and Fine-Mapping GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease
Pages 105-111
Collagenase Injection: Journey from Bench to Current Advanced Clinical Use
Pages 115-125
Efficacy of Using Local Anesthesia Before Collagenase Injection in Reducing Overall Pain Experience in Patients Treated for Dupuytren Contracture: A Quasi-Randomized Study
Pages 127-129
Effect of Delayed Finger Extension on the Efficacy and Safety of Collagenase Clostridium Histolyticum Treatment for Dupuytren Contracture
Pages 131-136
The Use of Dynamic Dorsal Splint for Dupuytren Rehabilitation After Collagenase Injection
Pages 137-140
Prospective Multicenter, Multinational Study to Evaluate the Safety and Efficacy of Concurrent Collagenase Clostridium Histolyticum Injections to Treat Two Dupuytren Contractures in the Same Hand
Pages 141-144
Collagenase: What We May Never Know (A Discussion)
Pages 145-149
Controversy: Comparison of the Literature on PNF and CCH as Minimally Invasive Treatment Options for Dupuytren Disease
Pages 151-157
Tips and Pearls for PNF and Collagenase: A Ten-Year Personal Experience
Pages 161-170
Clinical Results of Percutaneous Needle Fasciotomy for Dupuytren Contracture: Are There Significant Correlations Between Preoperative Dupuytren Diathesis Score and Contracture Recurrence?
Pages 171-177
Effectiveness of Percutaneous Needle Fasciotomy for Second or Higher Recurrence in Dupuytren Contracture
Pages 179-184
Controversy: How to Treat Severe PIP Contractures? - Collagenase Treatment
Pages 185-189
Controversy: How to Treat Severe PIP Contractures? - Surgical Correction
Pages 191-195
Correlation of Function with Deformity in Dupuytren Disease: The Condition-Specific Southampton Scoring Scheme Outperforms the Generic QuickDASH
Pages 199-203
Tonometry as an Outcome Measure for the Treatment of Early Dupuytren Disease
Pages 205-209
The Intra- and Interobserver Agreement on Diagnosis of Dupuytren Disease, Measurements of Severity of Contracture, and Disease Extent
Pages 211-215
Variation in Range of Movement Reporting in Dupuytren Disease
Pages 217-220
Use of Digital Photography and Mobile Device Application to Assess Finger Deformity in Dupuytren Disease
Pages 221-223
Application for Determining the Degree and Diagnose Code of Dupuytren Contracture by Digital Photography
Pages 225-228
Treatment of Dupuytren Disease: Where Are We Now?
Pages 231-239
Steroid Injection and Needle Aponeurotomy for Dupuytren Disease
Pages 241-249
Minimally Invasive Treatment of Dupuytren Contracture: Collagenase Versus PNF
Pages 251-258
Comparative Effectiveness of Collagenase Injection for Dupuytren Contracture
Pages 259-270
Short-Term Cost-Utility Analysis of Collagenase Versus Fasciectomy for Dupuytren Contracture
Pages 271-275
An Easy Way for Clinical Validation of the Pharmacoeconomic Model in Dupuytren Disease
Pages 277-281
Preliminary Soft-Tissue Distraction with the Digit WidgetTM in the Management of Advanced Dupuytren Contracture at the Proximal Interphalangeal Joint
Pages 285-290
Is Recurrence After Treatment Predictable? Risk Factors in Dupuytren Disease
Pages 291-297
Is Recurrence of Dupuytren Disease Avoided in Full-Thickness Grafting?
Pages 299-304
The Use of Acellular Dermal Matrix in Dupuytren Disease
Pages 305-309
Indications of the Continuous Extension Technique (TEC) for Severe Dupuytren Disease and Recurrences
Pages 311-316
Experience in Treating Patients with Stage IV of Dupuytren Contracture (PNF vs. Fasciectomy)
Pages 317-321
Controversy: Splinting for Dupuytren Contracture
Pages 323-329
Introduction to Radiation Biology When Treating Hyperproliferative Benign Diseases
Pages 333-339
Review of Radiation Therapy for Palmar and Plantar Fibromatosis (Dupuytren and Ledderhose Disease)
Pages 341-355
Splinting as a Therapeutic Option in Dupuytren Contractures
Pages 357-361
Treatment Options for Patients with Adhesive Capsulitis (Frozen Shoulder)
Pages 363-369
International Patient Survey (Part 2: Ledderhose Disease)
Pages 371-379
Peyronie Disease
Pages 381-388
The Next Stage of Clinical Dupuytren Research: Biomarkers and Chronic Disease Research Tools
Pages 391-407
The Future of Basic Dupuytren Disease Research
Pages 409-411
How Should We Fund Basic Research of Dupuytren Disease?
Pages 413-415
Clinical Research: International Collaboration to Execute High-Powered Clinical Trials
Pages 417-419
Patient-Rated Outcome Measures and Dupuytren Contracture
Pages 421-426
IDDB: An International Research Database of the Dupuytren Foundation
Pages 427-435
International Clinical Research – The Australian Perspective: A Personal View
Pages 437-440
Open Questions and Potential Answers
Pages 441-445
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