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Diabetes and Kidney Disease reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are covered, as well as an overview to the novel approaches being designed by leading researchers in the field.
A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.
Contents
1 The Background History of Diabetic Nephropathy .............................................. 1
Michelle Haggar and Vivian Fonseca
Part I Natural Course, Pathogenesis, Morphology and Genetics
2 Diabetic Nephropathy: Scope of the Problem ....................................................... 9
Jing Chen
3 Natural Course (Stages/Evidence- Based Discussion) ........................................... 15
Aileen K. Wang and Tina K. Thethi
4 Pathogenesis of Diabetic Nephropathy:
Hemodynamic Alterations/Renin Angiotensin System ......................................... 29
Arnold B. Alper Jr.
5 Renal Structural Changes in Type 1 and 2 Diabetes Mellitus:
Pathology, Pathogenesis, and Clinical Correlations ............................................. 39
Jeffrey Aufman and Guillermo A. Herrera
6 Diabetes in Children and Adolescents .................................................................... 63
Ihor V. Yosypiv
Part II Clinical Presentation and Associated Disorders
7 Screening, Early Diagnosis, Genetic Markers,
and Predictors of Diabetic Nephropathy ............................................................... 79
Eric P. Cohen and Jean-Marie Krzesinski
8 Atypical Presentations of Diabetic Nephropathy and Novel Therapies .............. 91
Louis J. Imbriano, John K. Maesaka, Joseph Mattana,
Shayan Shirazian, and George Jerums
9 Albuminuria–Proteinuria in Diabetes Mellitus ..................................................... 107
Surya V. Seshan and Alluru S. Reddi
10 Hypertension in Diabetes Mellitus ......................................................................... 119
William J. Elliott
11 Cardiovascular Disease in Diabetic Nephropathy ................................................ 135
L. Lee Hamm, Tina K. Thethi, and Kathleen S. Hering-Smith
12 Dyslipidemia in Diabetes Mellitus and Chronic Kidney Disease ......................... 141
Armand Krikorian and Joumana T. Chaiban
13 Diabetic Eye Disease ................................................................................................ 153
Azin Abazari, Nicola G. Ghazi, and Zeynel A. Karcioglu
14 Pregnancy and Diabetic Nephropathy ................................................................... 163
N. Kevin Krane, Radha Pasala, and Adrian Baudy IV
15 Transplantation: Kidney, Kidney–Pancreas Transplant ...................................... 175
Rubin Zhang and Anil Paramesh
Part III Treatment and Prognosis
16 Glycemic Control ..................................................................................................... 205
Allison J. Hahr and Mark E. Molitch
17 Computerized Clinical Decision Support for Patients
with Diabetes and Chronic Kidney Disease ........................................................... 215
Shayan Shirazian, John K. Maesaka, Louis J. Imbriano,
and Joseph Mattana
18 Antihypertensive and Other Treatments in Early Stages
of Diabetic Nephropathy ......................................................................................... 229
William J. Elliott
19 Novel Treatments and the Future of Diabetic Nephropathy:
What Is on the Horizon? ......................................................................................... 241
Vecihi Batuman
Index .................................................................................................................................. 251
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