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LIBRERIA STUDIUM
Damage-Associated Molecular Patterns in Human Diseases
Volume 1: Injury-Induced Innate Immune Responses
Land
Editore
Springer
Anno
2019
Pagine
870
ISBN
9783030087562
150,00 €
DA SCONTARE
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
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Prologue: The Term “Immunity” over the Course of Time
Land, Walter Gottlieb
Pages 3-11
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The Three Major Paradigms in Immunology
Land, Walter Gottlieb
Pages 13-27
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Epilogue: What Major Paradigm in Immunology Comes Next?
Land, Walter Gottlieb
Pages 29-30
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Prologue: The Guardians of Homeostasis
Land, Walter Gottlieb
Pages 33-42
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Innate Immune Recognition Molecules
Land, Walter Gottlieb
Pages 43-108
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Epilogue: The Innate Immune System: A Global Player in Health and Disease
Land, Walter Gottlieb
Pages 109-109
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Prologue: The Whole Body as an Immune System
Land, Walter Gottlieb
Pages 113-113
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Mobile Innate Immune Cells
Land, Walter Gottlieb
Pages 115-158
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Sessile Innate Immune Cells
Land, Walter Gottlieb
Pages 159-186
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Epilogue : Cells of Our Immune System: A Whole Army of Defenders Far Beyond T and B Cells
Land, Walter Gottlieb
Pages 187-187
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Prologue: About DAMPs, PAMPs, and MAMPs
Land, Walter Gottlieb
Pages 191-217
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Endogenous DAMPs, Category I: Constitutively Expressed, Native Molecules (Cat. I DAMPs)
Land, Walter Gottlieb
Pages 219-268
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Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs)
Land, Walter Gottlieb
Pages 269-305
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Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs)
Land, Walter Gottlieb
Pages 307-351
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Exogenous DAMPs, Category IV (Cat. IV DAMPs)
Land, Walter Gottlieb
Pages 353-368
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Epilogue: The Well-Dosed Work of DAMPs in Their Commission to Restore and Maintain Homeostasis
Land, Walter Gottlieb
Pages 369-370
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Prologue: Innate Immune Tools to Defend Against Stressful Injury: Success and Failure
Land, Walter Gottlieb
Pages 373-375
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Cell-Autonomous (Cell-Intrinsic) Stress Responses
Land, Walter Gottlieb
Pages 377-426
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Regulated Cell Death
Land, Walter Gottlieb
Pages 427-466
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Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs
Land, Walter Gottlieb
Pages 467-470
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Prologue: The Various Facets of Innate Immune Effector Responses
Land, Walter Gottlieb
Pages 473-474
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Cellular Inflammatory Responses
Land, Walter Gottlieb
Pages 475-590
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Humoral Innate Immune Effector Responses
Land, Walter Gottlieb
Pages 591-634
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Regulation of Innate Inflammatory Responses
Land, Walter Gottlieb
Pages 635-658
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Epilogue: How Should Clinicians Implement the Complex Innate Immune Effector Responses at the Patient’s Bedside?
Land, Walter Gottlieb
Pages 659-659
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Prologue: The “Ready-to-Go” Lymphocytes of the Immune System
Land, Walter Gottlieb
Pages 663-663
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Activation and Function of Innate Lymphoid Cells
Land, Walter Gottlieb
Pages 665-691
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Activation and Function of Unconventional T Cells
Land, Walter Gottlieb
Pages 693-711
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Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches
Land, Walter Gottlieb
Pages 713-714
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Prologue: The “Long Arm” of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes
Land, Walter Gottlieb
Pages 717-722
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Antigen Uptake, Processing, and Presentation by Dendritic Cells
Land, Walter Gottlieb
Pages 723-748
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Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote Destructive Adaptive Immune Responses
Land, Walter Gottlieb
Pages 749-790
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Antigen in the Absence of DAMPs Promotes Immune Tolerance: The Role of Dendritic Cells and Regulatory T Cells
Land, Walter Gottlieb
Pages 791-827
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An Impressive Example of Peripheral Tolerance Against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens
Land, Walter Gottlieb
Pages 829-835
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Immunometabolism of Dendritic Cells and T Cells
Land, Walter Gottlieb
Pages 837-844
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Role of DAMPs in Tissue Regeneration and Repair
Land, Walter Gottlieb
Pages 845-868
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Epilogue: The “DAMPome” as a Key Player in the Pathogenesis of Many Human Diseases
Land, Walter Gottlieb
Pages 869-870
