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Clinical Development of Genomic Medicine in Pulmonary Diseases: Are Genetic Factors Enough to Determine the Phenotype and Inheritance of Pulmonary Diseases?
Pages 3-14
This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases.
This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.
Clinical Development of Genomic Medicine in Pulmonary Diseases: Are Genetic Factors Enough to Determine the Phenotype and Inheritance of Pulmonary Diseases?
Pages 3-14
Approaches to Understanding the Genetic Basis of Complex Diseases: Overview—What Is the Rationale for the Genome-Wide Approach to Understand Complex Diseases, Its Application and Limitations
Pages 15-35
Bronchial Asthma: Is Asthma Inherited?
Pages 39-56
COPD: Hereditary (A1-AT) and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of COPD?
Pages 57-75
Smoking Behavior and Cessation (Nicotine Addiction): Are Genetic Factors Involved in Smoking Behavior?
Pages 77-91
Cystic Fibrosis, Primary Ciliary Dyskinesia, and Diffuse Panbronchiolitis: Hereditary and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases?
Pages 93-106
Pulmonary Fibrosis: Hereditary and Non-hereditary—What Are the Role of Genetic Factors in the Pathogenesis of Pulmonary Fibrosis?
Pages 107-133
Other Diffuse Lung Diseases: Diffuse Cystic Lung Diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary Alveolar Proteinosis, and Pulmonary Alveolar Microlithiasis—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases?
Pages 135-160
Pulmonary Vascular Diseases: Pulmonary Hypertension and HHT—What Are the Roles of Genetic Factors in the Pathogenesis of Pulmonary Vascular Diseases?
Pages 161-167
Mycobacterial Infection: TB and NTM—What Are the Roles of Genetic Factors in the Pathogenesis of Mycobacterial Infection?
Pages 169-191
Pulmonary Malignancies (1): Lung Cancer—What Are the Roles of Genetic Factors in Lung Cancer Pathogenesis?
Pages 193-206
Pulmonary Malignancies (2): Mesothelioma—What Are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma?
Pages 207-224
Genetic Factors in Sleep Disorders: What Are the Roles of Genetic Factors in the Pathogenesis of Sleep Disorders?
Pages 225-254
Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
Pages 255-271
EGFR: How Important Is EGFR Mutation Status in the Management of Lung Cancer?
Pages 275-293
ALK and Others: How Important Are ALK and Other Mutations in the Management of Lung Cancer?
Pages 295-315
Application of High-Throughput Technologies in Personal Genomics: How Is the Progress in Personal Genome Service?
Pages 319-331
Nucleic Acid Amplification-Based Diagnostics for Pulmonary Diseases: What Is the Current State and Perspectives of Nucleic Acid Amplification Technologies Used in Diagnostics Associated with Pulmonary Diseases?
Pages 333-344
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