Informazioni
Non ci sono recensioni
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
Cholesterol Crystals in Atherosclerosis and Other Related Diseases
Abela, Nidorf
Editore
Springer
Anno
2023
Pagine
504
ISBN
9783031411915
140,00 €
DA SCONTARE
This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid’ cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer’s. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.
Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.
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Front Matter
Pages i-xv
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Overview
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Front Matter
Pages 1-1
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- Stefan Mark Nidorf, George S. Abela, James E. Muller
Pages 3-14
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- Stefan Mark Nidorf, George S. Abela
Pages 15-26
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Physical Properties and Imaging of Cholesterol Crystals: In Vitro
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Front Matter
Pages 27-27
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- Stanley Flegler, Abigail Vanderberg, Melinda Frame, Carol Flegler, Alicia Withrow, Michael Rich et al.
Pages 29-48
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- Jenny Capua-Shenkar, Neta Varsano, Howard Kruth, Lia Addadi
Pages 49-71
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Physical Properties and Imaging of Cholesterol Crystals: In Vivo
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Front Matter
Pages 73-73
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- Jinwei Tian, Xiang Peng, Yanwen Zhang, Zhifeng Qin, Peng Zhao, Yani Wang et al.
Pages 75-87
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Detecting Cholesterol Crystals Clinically in Spontaneous Aortic Plaque Rupture
- Kazuhisa Kodama, Chikao Yutani, Sei Komatsu, Satoru Takahashi
Pages 89-101
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Lipidology of Atherosclerosis
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Front Matter
Pages 103-103
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- Sean P. Gaine, Steven R. Jones, Peter P. Toth
Pages 105-126
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Formation of CCs in Endothelial Cells
- Yvonne Baumer, Lola R. Ortiz-Whittingham, Andrew S. Baez, Tiffany M. Powell-Wiley, William A. Boisvert
Pages 127-142
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Cholesterol Crystals and Tissue Injury
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Front Matter
Pages 143-143
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Atherosclerotic Plaque Morphology and the Conundrum of the Vulnerable Plaque
- Stefan Mark Nidorf, Ryan Madder, Ahmed Elshafie, George S. Abela
Pages 145-160
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The Role of Cholesterol Crystals in Plaque Rupture Leading to Acute Myocardial Infarction and Stroke
- George S. Abela, Kusai Aziz
Pages 161-185
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Infarction Without Plaque Rupture
- Rocco Vergallo, Filippo Crea
Pages 187-202
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Athero-Embolism: A Manifestation of Atherosclerosis
- Rohan M. Prasad, Adolfo Martinez Salazar, Majid Yavari, George S. Abela, Christopher Hanson
Pages 203-218
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The Role of Cholesterol Crystals in the Development and Progression of Degenerative Valve Disease
- Khalid Saeed Al-Asad, Nadine El-Ayache, Abdullah Al-Abcha, George S. Abela
Pages 219-230
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Cholesterol Crystals and Inflammation
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Front Matter
Pages 231-231
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Activation of Systemic- and Intracellular Complement by Cholesterol Crystals
- Nathalie Niyonzima, Claudia Kemper, Bente Halvorsen, Tom Eirik Mollnes, Terje Espevik
Pages 233-255
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Role of CCs and Their Lipoprotein Precursors in NLRP3 and IL-1β Activation
- Kristiina Rajamäki, Katariina Öörni
Pages 257-274
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Molecular Pathomechanisms of Crystal-Induced Disorders
- Chongxu Shi, Shrikant R. Mulay, Stefanie Steiger, Hans-Joachim Anders
Pages 275-296
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- Samuel C. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
Pages 297-318
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Interaction of CCs with Other Crystalloids and Disease Conditions
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Front Matter
Pages 319-319
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- Binita Shah, Gary Ho, Sonal Pruthi, Michael Toprover, Michael H. Pillinger
Pages 321-349
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Calcium Crystals in Arterial Disease
- Sandeep Banga, Jagadeesh K. Kalavakunta, Oliver Abela, On Topaz
Pages 351-374
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Cholesterol Crystals in Diabetic Retinopathy
- Yazen A. Shihab, Yvonne Adu Agyeiwaah, Tim F. Dorweiler, Irina Pikuleva, Julia V. Busik, Maria B. Grant
Pages 375-387
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Cholesterol in the Central Nervous System in Health and Disease
- Ryan Skowronek
Pages 389-412
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Interaction Between Crystals, Inflammation, and Cancer
- Stefan Mark Nidorf, Abdallah Almaghraby, Yehia Saleh, Venkat R. Katkoori, Zain ul Abideen, Harvey L. Bumpers et al.
Pages 413-429
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The Interaction Between Infection, Crystals, and Cardiovascular Disease
- Subhashis Mitra, Stefan Mark Nidorf, Manel Boumegouas, George S. Abela
Pages 431-451
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The Potential Role of Cholesterol Crystals in Preeclampsia
- Robert A. Wild, Zain ul Abideen, Enhua Wang, Ayowale T. Oladeji, Nigel Paneth, Stefan Mark Nidorf et al.
Pages 453-464
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Treatment of Cholesterol Crystals
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Front Matter
Pages 465-465
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- George S. Abela, Sandra Hammer, Xuefei Huang, Julia V. Busik, Stefan Mark Nidorf
Pages 467-489
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Back Matter
Pages 491-504
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