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LIBRERIA STUDIUM
Libreria medica internazionale
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LIBRERIA STUDIUM
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Childhood Leukemia
Reaman, Smith
Editore
Springer
Anno
2011
Pagine
336
ISBN
9783642137808
140,00 €
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.
  • Serves as a comprehensive and up-to-date compendium on the biology, diagnosis, and treatment of childhood leukemia
  • Focuses especially on genomic approaches to risk stratification and the use of risk-adjusted treatment approaches
  • Includes detailed discussion of promising targeted agents and strategies for the development of new agents
  • Will prove invaluable to specialists, generalists and trainees alike
This book is a comprehensive and up-to-date compendium on all aspects of childhood acute lymphoblastic and acute myeloid leukemia, which together constitute the most frequent cancer in the pediatric age group. After introductory chapters on the epidemiology and biology of pediatric leukemia, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. Promising targeted agents are discussed, and strategies for the development of new agents are appraised. The late effects of leukemia and its therapy are then considered in depth, with due attention to management of the psychosocial impact of the disease. Finally, global strategies to improve leukemia care and outcome are reviewed, and future directions discussed. The authors are internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric leukemia and will prove invaluable to specialists, generalists, and trainees alike.

ix
Contents
Part I: Genetics and the Epidemiology of Leukemia in Children
1 Epidemiology of Acute Childhood Leukemia . . . . . . . . . . . . . . . . . . . . . 3
Julie A. Ross, Kimberly J. Johnson,
Logan G. Spector, and John H. Kersey
Part II: Biology of Pediatric Leukemia
2 The Biology of Acute Lymphoblastic Leukemia . . . . . . . . . . . . . . . . . . 29
William L. Carroll, Mignon Loh,
Andrea Biondi, and Cheryl Willman
3 Biology of Acute Myeloid Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Robert J. Arceci and Soheil Meshinchi
Part III: Treatment Considerations in Childhood Leukemia
4 Classification and Treatment of Acute Lymphoblastic Leukemia . . . . 79
Stephen P. Hunger, Valentino Conter, Elizabeth A. Raetz,
Maria Grazia Valsecchi, and Guenter Henze
5 Treatment of Acute Myeloid Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . 121
Brenda Gibson, John Perentesis, Todd A. Alonzo, and
Gertjan J.L. Kaspers
Part IV: The Impact of Pharmacogenetics and Pharmacogenomics
on Childhood Leukemia
6 Pharmacogenetic and Pharmacogenomic Considerations
in the Biology and Treatment of Childhood Leukemia . . . . . . . . . . . . . 163
Jun J. Yang, Parinda A. Mehta, Mary V. Relling, and Stella M. Davies
Part V: The Potential Role of Biologically Targeted Therapy
for Childhood Leukemia
7 Promising Targeted Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193
Patrick Brown, Gregory H. Reaman, Nita L. Seibel, and Pamela Kearns
x Contents
8 Strategies for New Agent Development and Clinical
Trial Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
Malcolm Smith, Meenakshi Devidas, Keith Wheatley,
Richard B. Lock, and Sally Hunsberger
Part VI: Late Effects of Leukemia and Its Therapy
9 Late Sequelae in Children with Acute
Lymphoblastic Leukemia: Impact on Long-Term
Survival and Quality of Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Joseph P. Neglia, Maura O’Leary, and Smita Bhatia
10 Acute Toxicities, Late Sequelae, and Quality of Survivorship
in Children with Acute Myeloid Leukemia:
The Impact of Allogeneic Stem Cell Transplant . . . . . . . . . . . . . . . . . . 265
Julianne Byrne, John Horan, and H. Stacy Nicholson
part VII: Psychosocial Implications of Acute Leukemia Diagnosis
and Treatment for Children and Families
11 Appreciation and the Interdisciplinary Management
of the Psychosocial Impact of Leukemia on Children
and Their Families . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
Anne L. Angiolillo, Momcilo Jankovic, Riccardo Haupt,
Kathleen Ruccione, E. Anne Lown, and Robert B. Noll
Part VIII: Global Strategies to Improve Leukemia
Care and Outcome for Children
12 Improved Outcome for Children with Acute Leukemia:
How to Address Global Disparities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305
Yaddanapudi Ravindranath, Hans Peter Wagner,
Giuseppe Masera, Fulgencio Baez, Anjo.J.P. Veerman,
Jacqueline Cloos, Raul Ribeiro, and Gregory H. Reaman
Part IX: Perspectives and Future Direction
13 Future Challenges and Opportunities to Improve
Outcomes for Children with Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . 325
Gregory H. Reaman and Franklin O. Smith
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
 

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