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Cerebrospinal Fluid in Clinical Neurology
Deisenhammer, Sellebjerg, Teunissen
Editore
Springer
Anno
2015
Pagine
280
ISBN
9783319012247
110,00 €
I prezzi indicati possono subire variazioni poiché soggetti all'oscillazione dei cambi delle valute e/o agli aggiornamenti effettuati dagli Editori.

The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.

  • The History of Cerebrospinal Fluid

    Deisenhammer, Florian

    Pages 3-16

  • Anatomy of CSF-Related Spaces and Barriers Between Blood, CSF, and Brain

    Tumani, Hayrettin

    Pages 17-24

  • Physiology and Constituents of CSF

    Tumani, Hayrettin

    Pages 25-34

  • Techniques, Contraindications, and Complications of CSF Collection Procedures

    Niemantsverdriet, Ellis (et al.)

    Pages 35-57

  • Importance of Pre-analytical Stability for CSF Biomarker Testing

    Willemse, Eline A. J. (et al.)

    Pages 59-77

  • Cell Count and Staining

    Strik, Herwig (et al.)

    Pages 81-100

  • Glucose and Lactate

    Tumani, Hayrettin (et al.)

    Pages 101-106

  • CSF Total Protein

    Tumani, Hayrettin (et al.)

    Pages 107-109

  • CSF Albumin: Albumin CSF/Serum Ratio (Marker for Blood-CSF Barrier Function)

    Tumani, Hayrettin (et al.)

    Pages 111-114

  • Immunoglobulins in Cerebrospinal Fluid

    Sellebjerg, Finn

    Pages 115-129

  • Detection of Infectious Agents

    Spreer, Annette

    Pages 131-142

  • Immunohistochemistry

    Höftberger, Romana (et al.)

    Pages 143-158

  • Methods for Biomarker Analysis

    Franciotta, Diego (et al.)

    Pages 159-171

  • Acute Infectious Diseases

    Schmutzhard, Erich (et al.)

    Pages 175-209

  • Chronic Infectious Inflammatory Diseases of the Central Nervous System

    Taba, Pille (et al.)

    Pages 211-245

  • Autoimmune Encephalitis

    Sonderen, Agnes (et al.)

    Pages 247-276

  • Chronic Noninfectious Inflammatory CNS Diseases

    Elovaara, Irina (et al.)

    Pages 277-291

  • CSF Findings in Guillain-Barré Syndrome: Demyelinating and Axonal Acute Inflammatory Polyneuropathies

    Illes, Zsolt (et al.)

    Pages 293-310

  • Alterations of the Cerebrospinal Fluid in Chronic Inflammatory Diseases of the Peripheral Nervous System

    Illes, Zsolt (et al.)

    Pages 311-327

  • Alzheimer’s Disease and Other Neurodegenerative Disorders

    Rosén, Christoffer (et al.)

    Pages 329-351

  • Paraneoplastic Neurological Syndromes

    Lewerenz, Jan (et al.)

    Pages 353-385

  • Laboratory Diagnosis of Subarachnoid Haemorrhage

    Otto, Markus (et al.)

    Pages 387-394

  • CSF-orrhoea

    Keir, Geoffrey (et al.)

    Pages 395-406

  • Guidelines on Cerebrospinal Fluid Analysis

    Hegen, Harald (et al.)

    Pages 407-428

 

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