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This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy.
Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.
Epidemiology and Socioeconomic Impact of CNS Metastases
Pages 3-18
Wilcox, Jessica A. (et al.)
Basic Biology of Brain Metastasis
Pages 19-35
Vishnoi, Monika (et al.)
Preclinical Models of Brain Metastasis
Pages 37-51
Zhu, Lucía (et al.)
Pathology of Brain Metastases
Pages 53-67
Pisapia, David J.
Role of Precision Medicine in Patients with CNS Metastasis
Pages 69-82
Kim, Albert Eusik (et al.)
Classification of Brain Metastases
Pages 83-93
Sperduto, Paul W.
The Role of Advanced Imaging in the Management of Brain Metastases
Pages 95-113
Lin, Eaton (et al.)
Clinical Presentation of Central Nervous System Metastases
Pages 117-123
Donovan, Laura E. (et al.)
Management of Seizures in Brain Metastases
Pages 125-137
Bhatia, Ankush (et al.)
Cerebrovascular Complications in Patients with Cancer
Pages 139-149
Burch, Jaclyn E. (et al.)
Mood Disorders in Patients with CNS Metastases
Pages 151-167
Chilcote, Kaleena
Leptomeningeal Disease and the Role of Intrathecal Therapy
Pages 169-186
Saadeh, Fadi (et al.)
Paraneoplastic Neurological Disorders
Pages 187-206
Buckley, Monica Weaver (et al.)
Systemic Therapy of Brain Metastases: Lung Cancer
Pages 207-217
Lauko, Adam (et al.)
Systemic Therapy of Brain Metastases: Breast Cancer
Pages 219-233
Swartz, Leigh Klaus (et al.)
Systemic Therapy for Brain Metastases: Melanoma
Pages 235-244
Weiss, Sarah (et al.)
Systemic Therapy for Brain Metastases in Other Primary Cancers (Genitourinary, Gastrointestinal, Gynecology, Head/Neck)
Pages 245-257
Parikh, Karishma M. (et al.)
Management of Solid Tumor CNS Metastases in Children
Pages 259-268
Parker, Whitney E. (et al.)
Basic Radiobiology and Radiation Physics Primer
Pages 271-279
Lebow, Emily S. (et al.)
Role of Whole-Brain Radiotherapy
Pages 281-298
Lynch, Connor (et al.)
Stereotactic Radiosurgery Technology
Pages 299-314
Julie, Diana A. R. (et al.)
Stereotactic Radiosurgery: Indications and Outcomes in Central Nervous System and Skull Base Metastases
Pages 315-328
Ruiz-Garcia, Henry Jeison (et al.)
Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases
Pages 329-341
Torok, Jordan A. (et al.)
Challenges and Controversies in Stereotactic Radiosurgery
Pages 343-354
Shah, Jugal K. (et al.)
Synergy of Immunotherapy and Radiosurgery
Pages 355-369
Brandmaier, Andrew G. (et al.)
Salvage Irradiation for Patients with Recurrent Brain Metastases
Pages 371-378
Iorio-Morin, Christian (et al.)
Applications of Stereotactic Radiosurgery for Brain Metastases
Pages 379-391
Save, Akshay V. (et al.)
Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases
Pages 393-405
Robert, Stephanie M. (et al.)
Neurocognitive Effects of Brain Metastases and Their Treatment
Pages 407-425
Feghali, Karine A. (et al.)
The Role of Surgery in the Management of Brain Metastases
Pages 429-440
Traylor, Jeffrey I. (et al.)
Intraoperative Brachytherapy for Resected Brain Metastases
Pages 441-456
Wernicke, A. Gabriella (et al.)
Laser Interstitial Thermal Therapy for Brain Metastases and Radiation Necrosis
Pages 457-472
Traylor, Jeffrey I. (et al.)
Preventing Cranial Wound Complications in Cancer Patients
Pages 473-484
Lee, James C. (et al.)
Introduction to Spinal Metastases
Pages 487-494
Hussain, Ibrahim (et al.)
Epidemiology of Spinal Metastatic Disease
Pages 495-502
Berry-Candelario, John (et al.)
Bone Metabolism in CancerPages 503-511
Rachner, Tilman D. (et al.)
Systemic Therapies for Patients with Metastatic Spinal Disease
Pages 513-522
Vlachostergios, Panagiotis J. (et al.)
The Role of Advanced Imaging in Spinal Metastases
Pages 523-534
Karimi, Sasan (et al.)
Decision-Making Algorithms for Surgical Treatment of Spine Metastatic Disease
Pages 535-540
Pennicooke, Brenton H. (et al.)
Biomechanics of Spinal Fixation in Metastatic Disease
Pages 543-557
Ho, Allen L. (et al.)
Separation Surgery for Spinal Metastases
Pages 559-568
Rothrock, Robert J. (et al.)
Vertebrectomy for Spinal Metastases
Pages 569-574
Kalb, Samuel (et al.)
Minimally Invasive Surgery for Spinal Metastases
Pages 575-582
Rothrock, Robert J. (et al.)
Deformity Secondary to Vertebral Body Metastases
Pages 583-601
Pennington, Zach (et al.)
Postoperative Complications and Spinal Metastases
Pages 603-612
Yasin, Bushra (et al.)
Vertebral Augmentation Procedures for Treatment of Pathologic Vertebral Body Fractures
Pages 613-621
Schwarz, Justin (et al.)
Spinal Laser Interstitial Thermal Therapy for Metastatic Tumors
Pages 623-634
Evans, Linton T. (et al.)
Optimizing Wound Healing in Metastatic Spine Surgery
Pages 635-642
Bernstein, Jaime L. (et al.)
Contemporary Radiation for Spinal Metastasis and Spinal Cord Compression
Pages 643-658
Roberson, John (et al.)
Intraoperative Radiation for Spinal Metastatic Disease
Pages 659-670
Imber, Brandon S. (et al.)
Approach to Pain in Patients with Central Nervous System Metastases
Pages 673-685
Chai, Thomas (et al.)
Interventions for Refractory Pain in Cancer Patients
Pages 687-693
Kaplitt, Michael G.
Complementary and Integrative Therapies (CIM) in Patients with CNS Metastasis
Pages 695-703
Narayanan, Santhosshi (et al.)
The Palliative Care of Patients with Brain Metastases
Pages 705-718
Harrison, Rebecca A. (et al.)
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