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The Basis of Regional Therapy, Pharmacology, Hyperthermia, and Drug Resistance
Pages 3-15
This book is a state-of-the-art overview of cancer regional therapy (CRT) for the surgeons and interventional radiologists active in CRT development and research. The goals of this book are 1) to review the theory and practice of cancer regional therapies including pharmacology, devices, techniques, and workflow, 2) illustrate the most common procedures performed in the interventional and operating rooms, and 3) discuss data supporting use of CRT. This is meant to be a definitive text on the theory and practice of CRT. It begins with a summary of the history, technical principles that underlie regional therapy. The following parts discuss current data and practice in peritoneal, liver, limb, pleural and other sites. Included in the practice are considerations of workflow and financial issues revolving around CRT. Novel techniques and therapies under investigation are presented to inform the direction of the field.
Cancer Regional Therapy summarizes the history, current technology, common procedures, and future prospects in this field and includes procedures from many surgical and interventional radiologic disciplines.
The Basis of Regional Therapy, Pharmacology, Hyperthermia, and Drug Resistance
Pages 3-15
Novel Biological Therapies with Direct Application to the Peritoneal Cavity
Pages 17-26
Y-90 Radiomicrosphere Therapy: Principles and Clinical Use in Colorectal Cancer Liver Metastases
Pages 27-42
Principles of Percutaneous Ablation in the Liver
Pages 43-53
Regional Gene Therapy for Cancer
Pages 55-71
Historical Perspective for Regional Peritoneal Therapy: HIPEC, EPIC, and Port-Based Therapy
Pages 75-81
Rationale Behind HIPEC/Molecular and Genetic Considerations in HIPEC
Pages 83-91
Data for HIPEC for Pseudomyxoma Peritonei/Tumors of the Appendix
Pages 93-100
Data for HIPEC in Colorectal Cancer (T4 Lesions and Metastases)
Pages 101-112
Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Peritoneal Metastasis of Gastric Cancer
Pages 113-124
Regional Therapy for the Treatment of Ovarian Cancer: HIPEC and Intraperitoneal Chemotherapy
Pages 125-140
Mesothelioma and Miscellaneous Disease Processes
Pages 141-153
Anesthetic Considerations for Regional Therapies
Pages 157-162
Postoperative Management of Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Pages 163-177
Complications of Cytoreductive Surgery and HIPEC
Pages 179-188
Liver Resection and HIPEC
Pages 189-197
Peritoneal Perfusion Techniques
Pages 199-211
Operative Pearls for Cytoreduction of the Difficult Abdomen and Pelvis
Pages 213-220
Novel Techniques and the Future of HIPEC (Immunotherapy, Viral Therapy)
Pages 221-234
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Pages 235-243
The History of Isolated Hepatic Perfusion for Liver Metastases and Current Indications for Use
Pages 247-256
Pump-Based Hepatic Arterial Infusional Therapy
Pages 257-264
Percutaneous Transcatheter Particle Therapies
Pages 265-279
Hepatic Perfusion: Surgical and Catheter
Pages 281-295
Percutaneous and Port Delivered Arterial Infusional Therapy for Liver Tumors
Pages 297-310
Regional Therapies in Hepatocellular Carcinoma and Cholangiocarcinoma
Pages 311-322
Regional Therapies for Hepatic Melanoma Metastases
Pages 323-340
Complications of Intra-Arterial Regional Liver Therapy
Pages 341-353
Infusion Technique
Pages 357-366
Hyperthermic Isolated Limb Perfusion for Melanoma
Pages 367-378
Isolated Limb Perfusion and Infusion in the Management of In-Transit Melanoma of the Extremities: Modern Data Affecting Practice
Pages 379-394
Trial Data for Sarcoma
Pages 395-409
Regional Therapy of Bladder Tumors
Pages 413-425
Delivery of Antineoplastic Therapeutics to the Central Nervous System
Pages 427-438
Intralesional Therapies: Oncolytic Viral Therapies, Immunostimulants
Pages 439-450
Ongoing Clinical Trials and Rationale in Regional and Oligometastatic Disease
Pages 451-460
Radiation Therapy
Pages 461-479
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