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Targeting PI3K/AKT/mTOR Pathway
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This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
Targeting PI3K/AKT/mTOR Pathway
Pages
Targeting the CDK4/6 Pathway in Breast Cancer
Pages
Fundamental Pathways in Breast Cancer 1: Signaling from the Membrane
Pages 3-12
Fundamental Pathways in Breast Cancer 2: Maintenance of Genomic Stability
Pages 13-17
Fundamental Pathways in Breast Cancer 3: Estrogen Biology
Pages 19-26
Fundamental Pathways in Breast Cancer 4: Signaling to Chromatin in Breast Development
Pages 27-37
Mouse Models of Breast Cancer: Deceptions that Reveal the Truth
Pages 49-60
Epidemiology, Lifestyle, and Environmental Factors
Pages 63-72
Chemoprevention
Pages 87-94
Surgical Prevention
Pages 95-99
Premalignant and Pre-invasive Lesions of the Breast
Pages 103-120
Prognostic and Predictive Role of Genetic Signatures
Pages 121-131
Special Types of Breast Cancer and Non-epithelial Tumors
Pages 133-139
Pathology After Neoadjuvant Treatments
Pages 141-147
Breast Cancer Genomics
Pages 149-156
The Pathology Report
Pages 157-168
Radiological Screening of Breast Cancer: Evolution
Pages 171-203
Innovation in Breast Cancer Radiology
Pages 205-246
Nuclear Medicine in the Clinical Management (ROLL, SNB, and PET)
Pages 247-264
One-Step Systemic Staging for Patients with Breast Cancer
Pages 265-276
Imaging Findings After Surgery
Pages 277-315
Integrated Breast Biopsy for Best Radiological Diagnosis of Breast Cancer
Pages 317-331
Conservative Surgery
Pages 335-344
The Conservative Mastectomy
Pages 345-348
Surgical Treatment of Local Recurrence in Breast Cancer Patients
Pages 349-356
Management of the Axilla
Pages 357-363
Management of Intraepithelial Disease
Pages 365-368
Breast-Conserving Surgery After Neoadjuvant Therapy
Pages 369-383
Surgical Treatment of the Primary Tumor in Patients with Metastatic Breast Cancer (Stage IV Disease)
Pages 385-398
Breast Cancer in Lymphoma Survivors
Pages 399-414
Surgery of Metastases in Stage IV Breast Cancer
Pages 415-424
Breast Reconstruction with Tissue Expander and Definitive Implant Replacement
Pages 457-464
The Pedicled TRAM Flap in Breast Reconstruction
Pages 465-483
Contralateral Breast Management
Pages 495-501
Lipofilling
Pages 503-511
Breast Reconstruction with Biological and Non-biological Meshes and Matrices
Pages 513-520
How to Manage Complications in Breast Reconstruction
Pages 521-532
Adjuvant Systemic Therapies by Subtypes: Guidelines
Pages 535-539
Primary Systemic Therapies: Guidelines
Pages 541-548
Treatment of Advanced Disease: Guidelines
Pages 549-556
Endocrine Therapies in the Adjuvant and Advanced Disease Settings
Pages 557-568
Chemotherapy Regimens in the Adjuvant and Advanced Disease Settings
Pages 569-576
Anti-HER2 Therapies in the Adjuvant and Advanced Disease Settings
Pages 577-591
Adjuvant Treatment with Bone-Targeting Agents (Bisphosphonates and Anti-RANK-Ligand Antibody)
Pages 593-598
Systemic Treatment for Specific Medical Situations
Pages 599-607
Conceptual Basis and Principles of Radiation Oncology
Pages 611-619
Whole-Breast Irradiation Following Breast-Conserving Surgery for Invasive Breast Cancer
Pages 621-630
Whole-Breast Radiation Following Breast-Conserving Surgery in Noninvasive Cancer
Pages 631-635
Postmastectomy Radiation Therapy of Early Breast Cancer
Pages 637-644
Accelerated Partial Breast Irradiation
Pages 655-669
Radiotherapy for Metastatic Lesions
Pages 685-693
Emergencies in Breast Cancer
Pages 697-708
Breast Cancer (Diagnosed) During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients
Pages 709-718
Chest Wall Disease: The Clinical Continuum Between Inflammatory and Lymphangitic Breast Cancer
Pages 719-727
Male Breast Cancer
Pages 753-762
Treatment of Central Nervous System Involvement
Pages 763-767
Follow-Up of Patients with Breast Cancer
Pages 769-778
Targeting Immune Checkpoint
Pages 781-785
Targeting Genome Instability and DNA Repair
Pages 795-805
Targeting FGFR Pathway in Breast Cancer
Pages 819-822
Integrating Next-Generation Sequencing Data in Trial Design
Pages 823-827
Lifestyle and Breast Cancer
Pages 831-839
Psychological Support in Breast Cancer Patients: A Personalized Approach
Pages 841-847
HIFU and Radio Frequency as Alternatives to Surgery
Pages 849-854
Hyperthermia with Radiotherapy and with Systemic Therapies
Pages 855-862
Circulating miRNA in Early Diagnosis
Pages 875-881
Relevance of Stem Cells
Pages 883-888
Subgroup Analyses and Information from Clinical Trials on Breast Cancer
Pages 891-903
The Methodology of Meta-Analyses and Its Potential Contribution to Patient Care
Pages 905-913
Trial Designs and Biostatistics for Molecular-Targeted Agents
Pages 915-924
Bioinformatics for Clinical Use in Breast Cancer
Pages 925-928
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