Via Falloppio, 61 - PADOVA
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Libreria medica internazionale
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Brain Disorders in Critical Illness
Stevens, Sharshar, Ely
90,00 €
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Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This concise clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

  • Written and edited by scientists and clinicians at the forefront of biomedical research into the causes, prevention and management of brain dysfunction in the ICU
  • Content is presented in concise chapters, with numerous illustrations, executive summaries and a glossary of terms
  • Provides a detailed presentation of the dynamic and cutting-edge work in neuroscience and neurobiology which is unravelling the mechanisms and treatments of ICU-acquired brain dysfunction


  • Table of Contents

    Part I. Epidemiology and Outcomes:
    1. The epidemiology of critical illness brain dysfunction
    2. Cognitive dysfunction following critical illness
    3. Psychiatric disorders following critical illnesses
    4. Functional status and quality of life after critical illness
    5. Delirium and dementia: unraveling the complex relationship
    Part II. Behavioral Neurology in the ICU:
    6. Cognitive reserve
    7. Neurology of consciousness impairments
    8. Mechanisms of attention and attentional impairment
    9. Neurology of sleep and sleep disorders
    10. Neural basis of fear and anxiety
    Part III. Biological Mechanisms:
    11. Experimental models of cognitive dysfunction in infection and critical illness
    12. Neurobiological effects of systemic physiological and metabolic insults
    13. Cerebral ischemia and reperfusion
    14. Brain perfusion and autoregulation in systemic critical illness
    15. Delirium and neurotransmitter dysfunction
    16. Neuromodulatory and neurotoxic effects of sedative agents
    17. Neuroimmunological crosstalk in critical illness
    18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming
    19. The neuroendocrine response to critical illness
    20. Autonomic dysfunction in SIRS and sepsis
    21. Sepsis-induced neuronal dysfunction and death
    22. Neuroimmunomodulation in sepsis
    Part IV. Diagnosis of Brain Dysfunction:
    23. Clinical neurological assessment of the critically ill patient
    24. Bedside assessment of delirium in critically ill patients
    25. Electroencephalography and evoked potentials in critically ill patients
    26. Neuroimaging of delirium
    Part V. Preventative and Therapeutic Interventions:
    27. Environmental modification
    28. New paradigms in sedation of the critically ill patient
    29. Pharmacological management of delirium
    30. Pharmacogenomics and cerebral dysfunction
    31. Early physical and occupational therapy
    32. Rehabilitation after critical illness
    Part VI. Clinical Encephalopathy Syndromes:
    33. Drug-induced encephalopathy
    34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults
    35. Encephalopathy associated with alcohol or drug withdrawal
    36. Posterior reversible encephalopathy syndrome (PRES): the essential elements
    37. Hypoxic ischemic encephalopathy
    38. Sepsis-associated encephalopathy
    39. Seizures and status epilepticus in critical illness
    40. Encephalopathy and coma in acute liver failure and chronic liver failure
    41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline



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