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Bone Marrow Lymphoid Infiltrates: Diagnosis and Clinical Impact, describes the art of evaluating bone marrow lymphoid infiltrates in the context of their broad spectrum of normal, reactive and malignant status. Reference to the pathogenesis, clinical presentation and outcome complements the diagnostic parameters in each lymphoid disease entity. Physiological lymphoid development, microenvironmental factors and aging changes are unfolded in relation to their influential role in normal and pathological lymphoid conditions. The basic principles and gold standards that should govern a biopsy sample are given in detail, while the establishment of modern techniques is described in terms of their applicability, drawbacks and perspectives.
The 15 chapters that make up this book are the end product of the collaboration amongst European and American experts in different fields, each recognized in their own right for their contribution to bone marrow pathology, clinical approaches and management of lymphoid neoplasms as well as extensive knowledge of modern ancillary techniques.
Contents
1 New Insights in the Development of Human
B Lymphocytes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Bianca Blom
2 The Aging Lymphocyte. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Hector F. Valenzuela and Rita B. Effros
3 The Bone Marrow Microenvironment and Its
Impact in Acute and Chronic B Cell Malignancies . . . . . . . . . 35
Jan A. Burger and Dorothy A. Sipkins
4 The Expanding Diagnostic Role of Flow Cytometry
in Bone Marrow Studies of Patients with Lymphomas
and Plasma Cell Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Anna Porwit
5 The Application of Molecular Techniques
on Bone Marrow Trephines . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Falko Fend and Leticia Quintanilla-Martínez
6 Residual Disease Assessment and Its Role
in Monitoring Lymphoid and Plasma Cell Neoplasms . . . . . . 83
Konnie M. Hebeda, Patricia J.T.A. Groenen,
and J. Han van Krieken
7 Reporting of Bone Marrow Lymphoid Infiltrates . . . . . . . . . . 97
Yi-Hua Chen and LoAnn Peterson
8 Janus-Faced Lymphoid Infiltrates . . . . . . . . . . . . . . . . . . . . . . . 113
Dimitra Anagnostou
9 Singularities in Pediatric Bone Marrow
Lymphoid Processes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145
Sophia L. Yohe and Robert W. McKenna
10 Bone Marrow Involvement in Primary
Mature B and T Cell Leukemias . . . . . . . . . . . . . . . . . . . . . . . . 171
Ayoma D. Attygalle and Estella Matutes
11 A Step Forward in the Diagnosis of B-Cell
Lymphomas in the Bone Marrow . . . . . . . . . . . . . . . . . . . . . . . 191
Ahmet Dogan, Mine Hekimgil, and Nazan Ozsan
12 New Insights in Waldenström’s Macroglobulinemia . . . . . . . . 223
Meletios A. Dimopoulos and Evangelos Terpos
13 Bone Marrow in Hodgkin Lymphoma
and Mimickers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237
Stefano A. Pileri, Elena Sabattini, and Claudio Agostinelli
14 Misleading Features of Bone Marrow Involvement
by Peripheral T-Cell Lymphomas . . . . . . . . . . . . . . . . . . . . . . . 253
Philippe Gaulard and Sylvia Hoeller
15 Systemic Mastocytosis Associated with
Lymphoproliferative Disorders (SM-AHNMD) . . . . . . . . . . . . 271
Hans-Peter Horny, Karl Sotlar, and Peter Valent
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
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